Lansoprazole:一个更新的地方管理acid-related紊乱。

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马西森AJ,贾维斯B

Lansoprazole:一个更新的地方管理acid-related紊乱。

药。2001;61(12):1801 - 33所示。

PubMed ID
11693467 (在PubMed
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文摘

Lansoprazole胃酸分泌抑制剂,也表现出对幽门螺杆菌体外抗菌活性。目前治疗消化性溃疡疾病关注根除幽门螺旋杆菌感染患者维持治疗表示不是治愈的幽门螺旋杆菌和溃疡的愈合。Lansoprazole 30毫克结合阿莫西林1 g,克拉霉素250或500毫克,或甲硝哒唑400毫克每日两次与根除率从71年的94%,和溃疡愈合率一般都在精心设计的研究> 80%。此外,它是有效的奥美拉唑或rabeprazole-based方案包括这些抗菌药物。维护用兰索拉唑治疗30毫克/天明显比服用安慰剂或雷尼替丁更有效防止溃疡复发。重要的是,初步数据显示,lansoprazole-based根除治疗是有效的儿童和老人。短期治疗的患者gastro-oesophageal反流病(GORD), lansoprazole 15日30或60毫克/天明显比安慰剂更有效,300毫克/天或雷尼替丁cisapride 40毫克/天,相似功效pantoprazole 40毫克/天的食管炎的治疗。Lansoprazole 30毫克/天,奥美拉唑20毫克/天,pantoprazole 40毫克/天所有这些患者提供类似的症状缓解。食管炎患者的痊愈了。12个月的维护用兰索拉唑治疗15或30毫克/天,预防复发和相似或更有效的比奥美拉唑10或20毫克/天。 Available data in patients with NSAID-related disorders or acid-related dyspepsia suggest that lansoprazole is effective in these patients in terms of the prevention of NSAID-related gastrointestinal complications, ulcer healing and symptom relief. Meta-analytic data and postmarketing surveillance in >30,000 patients indicate that lansoprazole is well tolerated both as monotherapy and in combination with antimicrobial agents. After lansoprazole monotherapy commonly reported adverse events included dose-dependent diarrhoea, nausea/vomiting, headache and abdominal pain. After short-term treatment in patients with peptic ulcer, GORD, dyspepsia and gastritis the incidence of adverse events associated with lansoprazole was generally < or = 5%. Similar adverse events were seen in long-term trials, although the incidence was generally higher (< or = 10%). When lansoprazole was administered in combination with amoxicillin, clarithromycin or metronidazole adverse events included diarrhoea, headache and taste disturbance. In conclusion, lansoprazole-based triple therapy is an effective treatment option for the eradication of H. pylori infection in patients with peptic ulcer disease. Preliminary data suggest it may have an important role in the management of this infection in children and the elderly. In the short-term management of GORD, lansoprazole monotherapy offers a more effective alternative to histamine H2-receptor antagonists and initial data indicate that it is an effective short-term treatment option in children and adolescents. In adults lansoprazole maintenance therapy is also an established treatment option for the long-term management of this chronic disease. Lansoprazole has a role in the treatment and prevention of NSAID-related ulcers and the treatment of acid-related dyspepsia; however, further studies are needed to confirm its place in these indications. Lansoprazole has emerged as a useful and well tolerated treatment option in the management of acid-related disorders.

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药物
药物靶点
药物 目标 类 生物 药理作用 行动
Lansoprazole Potassium-transporting atp酶α链1 蛋白质 人类
是的
抑制剂
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