骨骼发育的影响选择性和非选择性cyclooxygenase-2抑制剂通过器官发生和纯种CRL fetogenesis:管理(WI) WUBR老鼠。

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下面你能看到B,名叫Burdan F, Szumilo J•马赛克Klepacz R, Dudka J

骨骼发育的影响选择性和非选择性cyclooxygenase-2抑制剂通过器官发生和纯种CRL fetogenesis:管理(WI) WUBR老鼠。

毒理学。2005年12月15日,216(2):204 - 23所示。Epub 2005年9月22日。

PubMed ID

16182428 (在PubMed

]

文摘

环氧合酶(COX)最常摄取抑制剂药物。这项研究的目的是评估的产前骨骼影响选择性(DFU)和非选择性cox - 2抑制剂(甲苯酰吡啶乙酸、布洛芬、吡罗昔康)。所有的测试化合物管理intragastrically怀孕Wistar鼠从怀孕7到21天。初始剂量设定在8.5毫克/公斤/剂量对甲苯酰吡啶乙酸和布洛芬,0.3和0.2毫克/公斤/剂量吡罗昔康和DFU。中间剂量增加10。最高剂量,除了布洛芬,是提升100倍。布洛芬的最高剂量是200毫克/公斤/剂量。甲苯酰吡啶乙酸和布洛芬是一天服用三次。吡罗昔康和DFU每日服用一次。随机选择的常规畸形学考试分析该病例后,四肢21-day-old胎儿被组织学、免疫组织化学和分子研究。 The proximal femoral epiphyses were separated and their ultrastructure evaluated. The expression of genes coding cytokines (IL-1alpha, IL-1beta, IL-6, TNF-alpha, TNF-beta) and proteins (COX-1, COX-2, cathepsin K, collagen types I, II and X; osteocalcin, osteopontin) was evaluated in femoral epiphyses by RNase Protection Assay and/or immunohistochemically. The articulate development was checked histologically and found undisturbed in any of the experimental groups. The epiphysis of the 21-day-old fetuses, presented physiological expression of COX-1 and COX-2, as well as cathepsin K, collagen types I, II and X; osteopontin, osteocalcin and TNF-alpha. Increased developmental skeletal variation was noted in groups exposed to the highest dose of nonselective drugs. Unlike the increased number of skeletal variations observed in fetuses exposed to highest doses of nonselective compounds, both groups of COX inhibitors did not disturb joint formation and morphology of femoral epiphyses when administered even in high maternal toxic doses.

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药物靶点

药物	目标	类	生物	药理作用	行动
甲苯酰吡啶乙酸	前列腺素合成酶1 G / H	蛋白质	人类	未知的	抑制剂	细节