性别和年龄对等离子体的影响水平的氯氮平及其代谢物:分析关键统计数据。
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林巷HY, Chang YC, Chang WH SK,曾欧美,Jann兆瓦
性别和年龄对等离子体的影响水平的氯氮平及其代谢物:分析关键统计数据。
中国精神病学。1999年1月;60 (1):36-40。
- PubMed ID
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10074876 (在PubMed]
- 文摘
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背景:先前的报道关于性别和年龄的影响对稳态血浆浓度的氯氮平及其主要代谢物,norclozapine clozapine-N-oxide,一直存有争议。由于等离子体的频率分布的水平是不对称和向右倾斜,统计方法(如方差分析和回归分析)实际上是早些时候不合适用于分析浓度变量的影响,可能导致不一致的结果。本研究的目的,适合统计,测量剂量的潜在影响,性别、年龄和体重对等离子体水平2氯氮平及其主要代谢物。方法:我们回顾性分析数据从一个稳态血浆氯氮平治疗药物监测研究,norclozapine, clozapine-N-oxide水平是在一大群进行的中国精神分裂症住院患者(男:女= 83:79比例;年龄,33.8 + / - 9.3年)。氯氮平的每日剂量范围从100到900毫克,意思是+ / - SD值为379.5 + / - 142.2毫克。等离子体浓度已经用高性能液相色谱法与紫外检测。采用多元线性回归量化各因素对等离子体水平的影响。等离子体水平的自然对数作为因变量,以克服偏态的问题。结果:调整后的影响,性别,年龄,体重,通过多元线性回归,每个1毫克剂量的增加可能提高氯氮平水平0.31%,norclozapine 0.27%, clozapine-N-oxide 0.16%。 Female patients had 34.9% higher clozapine levels and 36.3% higher norclozapine, with other variables being controlled. No sex differences were demonstrated for clozapine-N-oxide levels. Each 1-year increment in age would elevate the clozapine level by 1.1%, norclozapine by 1.0%, and clozapine-N-oxide by 1.0%. Body weight could not influence the levels of these compounds. CONCLUSION: The present results suggest that women possess higher plasma levels (about one third higher) of clozapine and norclozapine, but not the N-oxide metabolite. Each addition of 1 year in age elevated clozapine and either metabolite's levels by about 1%. Furthermore, every 1-mg increase in the daily dose raised clozapine and norclozapine concentrations by approximately 0.3%. These findings could assist clinicians in optimizing clozapine dosing strategies.
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