由装备酪氨酸蛋白激酶信号——干细胞因子受体。
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Roskoski R小
由装备酪氨酸蛋白激酶信号——干细胞因子受体。
生物化学Biophys Res Commun。2005年11月11日,337 (1):1-13。
- PubMed ID
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16129412 (在PubMed]
- 文摘
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干细胞因子和信号的设备,它的受体,在配子形成中扮演重要角色,造血作用,柱状细胞发育和功能和杀菌作用。此外,人类和小鼠胚胎干细胞表达工具记录。干细胞因子存在的可溶性和膜结合糖蛋白虽然工具包是一个受体酪氨酸蛋白激酶。完全没有干细胞因子或工具包是致命的。缺陷的产生红色和白血细胞的生产缺陷,hypopigmentation和不育。功能突变的装备与几个人类肿瘤包括急性骨髓性白血病,胃肠道间质瘤,肥大细胞瘤。设备由一个细胞外领域,跨膜段,近膜段和蛋白激酶域包含约80个氨基酸残基的插入。绑定装备结果干细胞因子受体二聚作用和激活的蛋白激酶活性。激活受体变得autophosphorylated酪氨酸残基,作为信号转导分子对接网站含有SH2域。适配器蛋白质APS、Src家族激酶和Shp2酪氨酰磷酸酶结合phosphotyrosine 568。 Shp1 tyrosyl phosphatase and the adaptor protein Shc bind to phosphotyrosine 570. C-terminal Src kinase homologous kinase and the adaptor Shc bind to both phosphotyrosines 568 and 570. These residues occur in the juxtamembrane segment of Kit. Three residues in the kinase insert domain are phosphorylated and attract the adaptor protein Grb2 (Tyr703), phosphatidylinositol 3-kinase (Tyr721), and phospholipase Cgamma (Tyr730). Phosphotyrosine 900 in the distal kinase domain binds phosphatidylinositol 3-kinase which in turn binds the adaptor protein Crk. Phosphotyrosine 936, also in the distal kinase domain, binds the adaptor proteins APS, Grb2, and Grb7. Kit has the potential to participate in multiple signal transduction pathways as a result of interaction with several enzymes and adaptor proteins.