皮质类固醇激素结合球蛋白对强的松在老鼠身上的药物动力学。

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Ko HC、阿尔蒙RR Jusko WJ

皮质类固醇激素结合球蛋白对强的松在老鼠身上的药物动力学。

制药研究》1995年6月,12 (6):902 - 4。

PubMed ID

7667198 (在PubMed

]

文摘

目的:外源性激素结合球蛋白的影响(cbre)在大鼠静脉注射强的松的药物动力学是确定测试“自由激素假说。”METHODS: A dose of CBG to yield 95% binding with 1000 ng/ml of prednisolone in vitro in rat plasma or saline was administered before dosing 2 mg/kg of prednisolone hemisuccinate or methylprednisolone intravenously. Drug concentrations in plasma samples were assayed by HPLC. RESULTS: Single administration of CBG decreased apparent prednisolone clearance by 56% (155 to 66 ml/min/kg) and reduced apparent VSS by 35% (4.1 to 2.7 L/kg) (p < 0.001). Methylprednisolone pharmacokinetics, studied as a negative control because the drug does not bind to CBG, did not change. CONCLUSIONS: The corticosteroid bound to CBG does not appear to be available for removal by clearance organs.

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药物载体

药物	航空公司	类	生物	药理作用	行动
强的松	Corticosteroid-binding球蛋白	蛋白质	人类	未知的	粘结剂	细节
醋酸强的松	Corticosteroid-binding球蛋白	蛋白质	人类	未知的	粘结剂	细节