描述的行为抑制血清素激活的机制诱导5-hydroxytryptophan修改明暗在老鼠身上测试。
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Artaiz我,Zazpe Del Rio J
描述的行为抑制血清素激活的机制诱导5-hydroxytryptophan修改明暗在老鼠身上测试。
Behav杂志。1998年3月,9(2):103 - 12所示。
- PubMed ID
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10065930 (在PubMed]
- 文摘
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在修改明暗勘探测试老鼠,但是5-hydroxytryptophan,剂量(25 - 50毫克/公斤),大脑皮层中的5 -内容大约翻了一番,所花费的时间减少了老鼠在白色的隔间,暗示anxiogenic效果。损耗的大脑5 -满意p-chlorophenylalanine(300毫克/公斤/天连续三天)导致了anxiolytic-like效果。相反,5 -再摄取抑制剂氟西汀时间减少了老鼠在白色的隔间。无显著交互p-chlorophenylalanine或氟西汀5-hydroxytryptophan被发现。几个5 -代理,其中一些内在anxiolytic-like效应在该测试中,研究了结合5-hydroxytryptophan。所有的药物和选择性亲和力与5-hydroxytryptophan 5-HT1A受体相互作用显著。5-hydroxytryptophan的抑制剂效果被丁螺环酮的敌意或逆转,在突触后5-HT1A受体部分激动剂,和100635年“沉默”5-HT1A受体拮抗剂,但不是完全激动剂8-OH-DPAT。5-HT2受体拮抗剂ritanserin部分抵消5-hydroxytryptophan效应在低剂量使用。5-HT3受体拮抗剂联合能够预防、低剂量,5-hydroxytryptophan anxiogenic效应;然而,5-HT3拮抗剂VA21B7 granisetron以及5-HT3/5-HT4拮抗剂tropisetron和选择性5-HT4受体拮抗剂RS 23597 - 190是无效的。 The results appear to be consistent with the hypothesis that relates increased activity of the 5-HT systems to increased anxiety. Even though different 5-HT receptor subtypes may be involved in the anxiogenic effect of a high dose of 5-hydroxytryptophan, postsynaptic 5-HT1A receptors appear to play a prominent role. Administration of 5-hydroxytryptophan may consequently represent a valid approach to analyse further the role of 5-HT agents, in particular those acting at 5-HT1A receptors, in animal models of anxiety.