常用的肌肉松弛剂治疗急性腰痛:回顾肌安宁,盐酸环苯扎林、metaxalone。
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托斯PP、Urtis J
常用的肌肉松弛剂治疗急性腰痛:回顾肌安宁,盐酸环苯扎林、metaxalone。
其他。2004年9月,26 (9):1355 - 67。
- PubMed ID
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15530999 (在PubMed]
- 文摘
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背景:腰痛初级保健访问是主要的原因。有很多可用的治疗方案,但是一些缺乏科学的支持。目的:本文的目的是讨论腰痛的病因和肌肉松弛剂常用的相对风险和收益管理的背部疼痛。方法:我们洲际搜索营销服必威国际app务2003年1月到2004年1月的数据来确定最常用的管理代理肌肉骨骼疼痛。肌安宁、盐酸环苯扎林、metaxalone代表> 45%的处方。Cochrane图书馆、MEDLINE和EMBASE数据库搜索(时间:1960年到2004年1月;必威国际app必威国际app搜索词:背痛,肌安宁、环苯扎林metaxalone、肌肉松弛剂和药物治疗)和参考hand-searched识别文章的列表。结果:肌安宁的三个试验(N = 197)位于Cochrane图书馆数据库。两个双盲,随机,安慰剂对照试验的安全性和有效性评价盐酸环苯扎林(N = 1405)在文献中被识别。三个双盲,安慰剂对照试验确定了metaxalone 2 (N = 428)的报告。 The types of adverse events seen with these agents involved the central nervous system, including drowsiness/sedation, fatigue, and dizziness. However, the efficacy of cyclobenzaprine hydrochloride was shown to be independent of its sedative effects, which were dose related. The potential for abuse with carisoprodol is of growing concern. CONCLUSIONS: Analgesic pain management for low back pain due to muscle spasm may be combined with a muscle relaxant. Cyclobenzaprine hydrochloride has the most recent and largest clinical trials demonstrating its benefit, but carisoprodol and metaxalone also appear to be effective. However, carisoprodol's usefulness is mitigated by its potential for abuse.
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- 药物