当地的孕激素合成和双重行为神经系统:神经保护和髓鞘形成。

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舒马赫M, Guennoun R,罗伯特F, Carelli C,加戈N, Ghoumari,冈萨雷斯Deniselle MC,冈萨雷斯SL, Ibanez说C, Labombarda F, Coirini H, Baulieu EE,尼古拉房颤

当地的孕激素合成和双重行为神经系统:神经保护和髓鞘形成。

增长霍恩IGF研究》2004年6月;14 5:S18-33。

PubMed ID

15135772 (在PubMed

]

文摘

孕酮(掠夺)是在大脑中合成,脊髓和周围神经。它的直接前体孕烯醇酮是来自循环或从当地作为细胞色素P450scc从头合成,胆固醇转化成孕烯醇酮,它是表达的神经系统。孕烯醇酮转化为掠夺3 beta-hydroxysteroid脱氢酶(3 beta-hsd)。原位杂交的研究表明,这种酶表达整个老鼠大脑,脊髓和背根神经节(DRG)主要由神经元。Macroglial细胞,包括星形胶质细胞,oligodendroglial细胞和雪旺细胞,也有能力合成食物,但表达和活性的3 beta-hsd这些细胞是由细胞间的相互作用。因此,雪旺细胞孕烯醇酮转化为食物在回应一个神经信号。现在有强有力的证据表明P450scc和3 beta-hsd表达在人类神经系统,掠夺合成也发生的地方。尽管只有少数研究解决食物的生物意义在大脑中合成,本地的自分泌/旁分泌动作合成食物可能会发挥重要作用在神经元的可行性和髓鞘的形成。学监的神经保护效应最近被记录在一个小鼠模型的脊髓运动神经元退化,摇摇晃晃鼠标。治疗有症状的梅花头老鼠食物15天减毒脊髓运动神经元的神经病理变化和有有益的影响肌肉力量和动物的存活率。 PROG may exert its neuroprotective effects by regulating expression of specific genes in neurons and glial cells, which may become hormone-sensitive after injury. The promyelinating effects of PROG were first documented in the mouse sciatic nerve and in co-cultures of sensory neurons and Schwann cells. PROG also promotes myelination in the brain, as shown in vitro in explant cultures of cerebellar slices and in vivo in the cerebellar peduncle of aged rats after toxin-induced demyelination. Local synthesis of PROG in the brain and the neuroprotective and promyelinating effects of this neurosteroid offer interesting therapeutic possibilities for the prevention and treatment of neurodegenerative diseases, for accelerating regenerative processes and for preserving cognitive functions during aging.

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药物

孕酮