相关的急性运动性眼低血压。

文章的细节

引用

复制到剪贴板

马丁哈里斯,Malinovsky V, B

相关的急性运动性眼低血压。

角膜切削Vis Sci投资。1994年10月,35 (11):3852 - 7。

PubMed ID

7928182 (在PubMed

]

文摘

目的:了解这些因素决定了降低眼内压(IOP)在急性动态运动。方法:exercise-IOP关系三个方面进行了研究。其中包括渐进式锻炼,有或没有二氧化碳isocapnia之外;比较的眼压反应训练和久坐不动的主题一个固定的外部工作负载;和锻炼后眼部beta-adrenoceptor封锁。渐进式锻炼包括7分钟每个周期测力计在30 - 90瓦,然后进步工作疲惫。训练和久坐不动的受试者血乳酸的反应的基础上定义固定的外部工作在90瓦(10分钟)。选择性β1-adrenoceptor封锁(倍他洛尔)和非选择性beta-adrenoceptor封锁(levobunolol)叠加在渐进式锻炼。眼压测量使用扁平张力测定法。结果:渐进式锻炼:眼压降低运动强度成比例。 Hypocapnia developed in the last minutes of exhausting work, but preventing hypocapnia with CO2 addition failed to lessen the decrease in IOP. Response to fixed external work load: Intraocular pressure decreased significantly more in sedentary than in trained subjects; this decline was correlated with elevations in blood lactate but not with changes in metabolic rate or plasma osmolarity. Selective and nonselective beta-adrenoceptor blockade: Both drugs lowered IOP at baseline and throughout graded exercise; the drugs and exercise had apparently additive ocular hypotensive effects. CONCLUSIONS: Acute dynamic exercise lowers IOP in a graded fashion proportional to relative, not absolute, work load. The IOP decline is correlated with blood lactate but not with PCO2 or plasma osmolarity changes, and exercise potentiates the ocular hypotensive effects of beta-adrenoceptor blockade.

DrugBank数据引用了这篇文章

药物靶点

药物	目标	类	生物	药理作用	行动
Levobunolol	beta 1肾上腺素能受体	蛋白质	人类	是的	拮抗剂	细节
Levobunolol	β2肾上腺素能受体	蛋白质	人类	是的	拮抗剂	细节