性别相关的差异表达和人类结肠癌的谷胱甘肽S-transferases的特点。
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Singhal党卫军,Saxena M, Awasthi年代,Ahmad H, Sharma R, Awasthi YC
性别相关的差异表达和人类结肠癌的谷胱甘肽S-transferases的特点。
Biochim Biophys学报。1992年11月15日,1171 (1):19-26。
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1420361 (在PubMed]
- 文摘
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在目前的研究中,谷胱甘肽的表达S-transferase(销售税)同功酶比较男性和女性在人类结肠组织。GST同功酶纯化和量化五男五女结肠组织样本。明显的差异观察的等电点聚焦概要文件(IEF)消费税,从男性和女性结肠组织。男性和女性结肠组织有三个常见的销售税山峰π值为9.2,6.7和4.8。额外的销售税π值的峰值6.2中所有女性都不是男性。基于动力学、免疫学和结构属性,这些同功酶分为α(9.2π),μ(π6.7和6.2)和π(4.8π)类。活动的alpha-class销售税在男性结肠癌是约。患病率高于女性结肠中相应的同工酶。pi-class消费税4.8是最主要的销售税在性别和其活动与CDNB衬底更丰富(约1.6倍)在女性结肠相比,在男性结肠癌。显著差异被认为在男性和女性之间的底物特异性结肠销售税4.8。 Sex related differences were also observed in the inhibition kinetics of GST pi from male and female colon in the presence of hematin. In addition, GST pi isolated from female colon was more thermostable as compared to the corresponding male isozyme. The thermostability of purified GST pi isozyme from males or females was not affected by incubation of the enzyme with either estrogen, testosterone or progesterone.