Alcaftadine的瘙痒与预防过敏性结膜炎。

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Mahvan TD,巴克利佤邦,Hornecker JR

Alcaftadine的瘙痒与预防过敏性结膜炎。

安Pharmacother。2012 Jul-Aug; 46 (7 - 8): 1025 - 32。doi: 10.1345 / aph.1Q755。Epub 2012年7月17日。

PubMed ID

22811343 (在PubMed

]

文摘

摘要目的:评价的安全性和有效性alcaftadine预防瘙痒与过敏性结膜炎。数据来源:进行医学文献检索MEDLINE / PubMed(2006 必威国际app- 2012年2月)和EMBASE(2006 - 2012年2月)用搜索术语alcaftadine和Lastacaft。从这些出版物引用综述了额外的资源。附加信息收集从美国政府网站(http://www.clinicaltrials.gov, http://www.fda.gov)和爱力根公司的制造商Lastacaft (http://www.lastacaft.com)。研究选择和数据提取:所有识别综述了英文文章和出版物药理学,药物动力学,疗效和安全性数据。首要任务是放置在临床试验。发表的数据合成:两个临床试验评估的有效性alcaftadine预防眼部瘙痒和结膜充血与过敏性结膜炎。一个审判alcaftadine安慰剂相比,另一个审判alcaftadine相比安慰剂和盐酸olopatadine安慰剂。这两项研究显示卓越的功效,临床和统计学,预防眼部瘙痒与安慰剂相比过敏性结膜炎。虽然结膜发红是2评估试验,试验证明了临床和统计学意义。 Both trials demonstrated a rapid onset of action of less than 15 minutes, as well as a duration of action greater than 16 hours, which supports the use of once-daily administration. Overall, alcaftadine was well tolerated, and common adverse effects, reported in less than 4% of patients, included ocular irritation, pruritus, erythema, and stinging or burning upon instillation. Ocular adverse effects were typically mild in severity and self-limiting. CONCLUSIONS: Alcaftadine is a safe and effective option for the prevention of ocular itching associated with allergic conjunctivitis, is dosed once daily, and is competitively priced among prescription medications for allergic conjunctivitis. Additional studies are needed to further evaluate the comparative efficacy among ocular antihistamine/mast cell stabilizing medications.

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药物

Alcaftadine