口服补充肌酸促进废弃萎缩的康复和改变的表达在人类肌肉肌原性的因素。

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Hespel P, Op Eijnde B, Van Leemputte M, Urso B, Greenhaff PL, Labarque V, Dymarkowski年代,Van Hecke P, Richter EA

口服补充肌酸促进废弃萎缩的康复和改变的表达在人类肌肉肌原性的因素。

杂志。2001年10月15日,536 (Pt 2): 625 - 33所示。

PubMed ID

11600695 (在PubMed

]

文摘

1。我们调查的影响腿固定和康复期间口服补充肌酸对肌肉体积和功能,以及肌原性的转录因子表达在人类主题。2。双盲试验是在年轻健康志愿者(n = 22)。一是用来固定2周的右腿。此后受试者参与了knee-extension康复计划(3 x周(1)会话,10周)。一半的受试者接受了一水肌酸(CR;从20克到每日5克),而其他人摄入安慰剂(P;麦芽糊精)。3所示。 Before and after immobilization, and after 3 and 10 weeks of rehabilitation training, the cross-sectional area (CSA) of the quadriceps muscle was assessed by NMR imaging. In addition, an isokinetic dynamometer was used to measure maximal knee-extension power (Wmax), and needle biopsy samples taken from the vastus lateralis muscle were examined to asses expression of the myogenic transcription factors MyoD, myogenin, Myf5, and MRF4, and muscle fibre diameters. 4. Immobilization decreased quadriceps muscle CSA (approximately 10 %) and Wmax (approximately 25 %) by the same magnitude in both groups. During rehabilitation, CSA and Wmax recovered at a faster rate in CR than in P (P < 0.05 for both parameters). Immobilization changed myogenic factor protein expression in neither P nor CR. However, after rehabilitation myogenin protein expression was increased in P but not in CR (P < 0.05), whilst MRF4 protein expression was increased in CR but not in P (P < 0.05). In addition, the change in MRF4 expression was correlated with the change in mean muscle fibre diameter (r = 0.73, P < 0.05). 5. It is concluded that oral creatine supplementation stimulates muscle hypertrophy during rehabilitative strength training. This effect may be mediated by a creatine-induced change in MRF4 and myogenin expression.

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药物

肌酸