比较的咳嗽Fosinopril和卡托普利的高血压患者ACE Inhibitor-Associated咳嗽的历史。

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大卫·D Jallad N, Germino弗兰克-威廉姆斯,威利•女士,de Silva J,魏德SM,米尔斯DJ

比较的咳嗽Fosinopril和卡托普利的高血压患者ACE Inhibitor-Associated咳嗽的历史。

J。”1995年10月,2 (10):806 - 813。

PubMed ID

11854791 (在PubMed

]

文摘

目的:咳嗽频率和严重程度与fosinopril和卡托普利评估在先前高血压患者血管紧张素转换酶抑制剂(ACEI)相关的咳嗽。设计:前瞻性,多中心,随机,8周的双盲治疗。病人:一百七十九例(轻度到中度高血压,不吸烟者,平均年龄58岁;55%的女性;72%的白人,6%的黑人,19%的西班牙裔)进行了研究。其他患者咳嗽病因、重要的伴随疾病或混淆药物被排除在外。干预措施:病人被随机分为fosinopril 10毫克(n = 85)或卡托普利5毫克(n = 94)每天一次。剂量可能会翻倍4周后血压控制。结果测量:主要终点是all-cough频率基于病人每日日记评级;累积的咳嗽频率分数计算。 Secondary end points included cough severity, nonproductive cough frequency, night awakenings, cough time of day, and spontaneously reported cough. RESULTS: Fosinopril and enalapril demonstrated similar blood pressure control. Significant cough profile differences were observed in favor of fosinopril: all-cough frequency was 40.6 plus minus 3.8 (mean plus minus SE) versus 52.8 plus minus 3.6 (p = 0.02); nonproductive cough frequency was 26.7 plus minus 3.5 versus 40.3 plus minus 3.4 (p less-than-or-equal 0.01); and cough time of day was 49.2 plus minus 5.2 versus 66.0 plus minus 5.0 (p = 0.02), for fosinopril and enalapril, respectively. Subgroup analysis revealed all-cough frequency was 33.5 plus minus 6.3 versus 56.6 plus minus 5.3 (p = 0.006) for fosinopril and enalapril, respectively, in patients who previously had cough on one of these two ACEI (predominantly enalapril). Ten (12%) fosinopril and 25 (27%) enelapril patients spontaneously reported cough (p = 0.01). CONCLUSIONS: Hypertensive patients with previous ACEI-associated cough reported less frequent cough with fosinopril compared to enalapril, based on cumulative patient diary scores and spontaneously reported cough. This difference was most apparent in the subgroup of patients who previously experienced cough associated with enalapril therapy. Patients with prior ACEI-associated cough may experience less frequent with fosinopril.

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药物

Fosinopril