瘦素治疗改变对食物刺激食欲和神经反应的大脑区域leptin-sensitive主题没有改变大脑结构。

文章的细节

引用

复制到剪贴板

Papageorgiou Farr OM、Fiorenza C、P, Brinkoetter M, Ziemke F,古永锵BB,罗哈斯R, Mantzoros CS

瘦素治疗改变对食物刺激食欲和神经反应的大脑区域leptin-sensitive主题没有改变大脑结构。

中国性金属底座。2014年12月,99 (12):E2529-38。doi: 10.1210 / jc.2014 - 2774。

PubMed ID

25279500 (在PubMed

]

文摘

背景:瘦素是一种能量摄入和支出的主要监管机构。患有先天性瘦素缺乏演示之后,大脑结构和功能的变化给瘦素。然而,同样获得了瘦素缺乏是否会操作还不清楚。目的:我们出发来确定患者的大脑获得瘦素缺乏可能在类似的方式对瘦素的反应。设计:我们使用功能性磁共振成像在短期和长期metreleptin治疗前后患者在三leptin-sensitive hypoleptinemia收购。9名健康女性作为normoleptinemic扫描控制。设置:设置是一个学术医疗中心。患者或其他参与者:参与者3 hypoleptinemic妇女和九normoleptinemic,匹配的女性。干预措施:我们使用metreleptin,重组瘦素,治疗24周hypoleptinemic女性。主要结果测量:我们测量神经的变化响应查看食品与非食品相比图像。 We hypothesized that metreleptin treatment would increase brain activity in areas related to cognitive control and inhibition and would decrease brain activity in areas related to reward processing, as compared to the normoleptinemic counterparts. RESULTS: Unlike patients with congenital leptin deficiency, hypoleptinemic patients demonstrated no structural brain differences from healthy controls and/or structural changes in response to treatment. Short-term metreleptin treatment in leptin-sensitive hypoleptinemic subjects enhances areas involved in detecting the salience and rewarding value of food during fasting, whereas long-term treatment decreases attention to food and the rewarding value of food after feeding. Furthermore, hypothalamic activity is modulated by metreleptin treatment, and leptin decreases functional connectivity of the hypothalamus to key feeding-related areas in these hypoleptinemic subjects. CONCLUSIONS: Leptin replacement in acutely hypoleptinemic women did not alter brain structure but did alter functional cortical activity to food cues in key feeding and reward-related areas.

DrugBank数据引用了这篇文章

药物

Metreleptin