抗菌cem - 101活动的描述对呼吸道病原体,包括耐多药肺炎球菌血清组19隔离。

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法雷尔DJ,撒德牌商品,Castanheira M, Biedenbach DJ, RN安公关,琼斯

抗菌cem - 101活动的描述对呼吸道病原体,包括耐多药肺炎球菌血清组19隔离。

Int J Antimicrob代理。2010年6月,35 (6):537 - 43。doi: 10.1016 / j.ijantimicag.2010.01.026。Epub 2010年3月7日。

PubMed ID

20211548 (在PubMed

]

文摘

杰姆- 101是一种新型的氟化macrolide-ketolide强有力的活动对细菌病原体易感或其他耐macrolide-lincosamide-streptogramin B (MLS (B)) -ketolide代理。杰姆- 101正在为口服和注射用药物的使用开发适度中度到严重的社区获得性细菌性肺炎。本研究的目的是评估cem - 101和比较器的活动对当代呼吸道感染(RTI)隔离。全球的生物样本,包括肺炎链球菌(n = 168;erythromycin-resistant 59.3%和18耐多药(MDR)血清组19株,莫拉克斯氏菌属复活(n = 21;11 beta-lactamase积极)、流感嗜血杆菌(n = 100;48 beta-lactamase积极),嗜血杆菌56和嗜血杆菌haemolyticus (n = 12),和嗜肺性军团菌(n = 30)。临床和实验室测试和解释进行了使用参考标准协会的方法。cem - 101是非常有效的对肺炎链球菌(最低抑制浓度为90%的生物(MIC90) = 0.25 mg / L;麦克风最高为0.5 mg / L)和2 -,> = 32倍比telithromycin更活跃和克林霉素,分别。 CEM-101 also demonstrated potent activity against S. pneumoniae MDR-19A strains (MIC90=0.5 mg/L). CEM-101 was the most potent antimicrobial agent tested against L. pneumophila, with all MIC values at < or = 0.015 mg/L (telithromycin MIC90=0.03 mg/L). CEM-101 was as potent as azithromycin against Haemophilus spp. RTI pathogens (MIC90=2 mg/L), with no variations for beta-lactamase production. CEM-101 MIC values against M. catarrhalis were all at < or =0.5mg/L. Interestingly, CEM-101 potency was ca. 6 log(2) dilutions greater than telithromycin MIC results among 44 beta-haemolytic streptococci having telithromycin MICs > or = 2 mg/L. CEM-101 exhibited the greatest potency and widest spectrum of activity against RTI pathogens among the tested MLS(B)-ketolide agents (azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin and quinupristin/dalfopristin) and was comparable overall with levofloxacin.

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药物

Solithromycin