抗抑郁药物的药理adinazolam triazolobenzodiazepine。

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拉赫蒂RA, Sethy VH, Barsuhn C,海丝特简森-巴顿

抗抑郁药物的药理adinazolam triazolobenzodiazepine。

神经药理学。1983年11月22日(11):1277 - 82。

PubMed ID

6320036 (在PubMed

]

文摘

Adinazolam, 1-dimethylaminomethyl triazolobenzodiazepine,定义的是一种有效的抗焦虑剂抑制应激增加血浆皮质类固醇。Adinazolam也是一个有效的pentylenetetrazole拮抗剂。的1-dimethylaminoethyl triazolo模拟u - 43465 f,在强调不活跃的老鼠测试,只对pentylenetetrazole弱活跃。Adinazolam和u - 43465 f之前显示在经典抗抑郁活性筛选试验。他们还发现了加强去甲肾上腺素的作用,这是符合已知的抗抑郁药的活动;u - 43465 f被发现equieffective丙咪嗪在这个测试。Adinazolam也是有效;然而,增强作用的大小并不好。去甲肾上腺素的吸收化合物只有弱受。增强作用或5 -羟色胺的摄取没有显著改变药理因素。 Receptor binding studies were negative except at the benzodiazepine receptor. Chronic treatment with adinazolam did not decrease the number of beta-adrenergic receptors in the cerebral cortex of the rat, in contrast to the positive effect of imipramine. The discovery of triazolobenzodiazepines with antidepressant activity is of special interest. These agents will hopefully have lower toxicity than the tricyclic antidepressants and thus possess a more favourable therapeutic index. This would be advantageous in the treatment of depression.

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药物

Adinazolam