药效学的marbofloxacin小腿肺炎病原体。

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程Illambas J,波特T, Z,莱克,斐J,利兹P

药效学的marbofloxacin小腿肺炎病原体。

Res兽医科学。2013年6月,94 (3):675 - 81。doi: 10.1016 / j.rvsc.2012.12.012。Epub 2013年1月31日。

PubMed ID

23375665 (在PubMed

]

文摘

氟喹诺酮类的药效学(PD)属性,marbofloxacin,测定牛呼吸道病原体Mannheima haemolytica和巴斯德菌multocida。6每个生物的致病性隔离,三个体外指标有效性和效力的确定,即最低抑制浓度(MIC)、最低杀菌浓度(MBC)和time-kill曲线。两个矩阵中的每个参数确定,穆勒辛顿汤(MHB)和牛血清。血清,MBC:麦克风比例是2.7:1 (m . haemolytica)和2.4:1 (p . multocida)。杀戮行动marbofloxacin有浓度依赖性的特点对m . haemolytica以及相互依存对p . multocida(在时间和浓度)。确认time-kill概要文件的特点、生长抑制由marbofloxacin在三个生物体液,还建立了体外牛血清,渗出液和漏出物,是从组织笼模型。体外time-kill数据建模与marbofloxacin的药代动力学特性,建立了在小腿肌内政府的剂量2毫克/公斤;三个层面的活动,即抑菌、3 log10减少和4 log10减少细菌数量确定。意味着AUC值(24小时)/麦克风(比例系数的变化表明inter-isolate可变性)为m . haemolytica基于血清麦克风,分别为31.3(41.6),57.7(42.4)和79.2 (44.6)h,分别。MHB对应的值是20.5(58.0),40.5(51.8)和51.2 (24.30)h,分别。 When allowance was made for binding of marbofloxacin to serum protein, the AUC(24h)/MIC values for serum were similar to those for MHB. Numerical AUC(24h)/MIC values for P. multocida were slightly lower than those obtained for M. haemolytica. These data establish for the first time inter-isolate variability in AUC(24h)/MIC values required for three levels of bacterial kill for two pathogenic species and thereby provide an indication of variability in serum concentration that might be required to achieve efficacy in clinical subjects.

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药物

Marbofloxacin