马波沙星及其代谢物n -去甲基-马波沙星在肉鸡体内的药代动力学特征及组织残馀。
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Anadon A, Martinez- larranaga MR, Diaz MJ, Martinez MA, Frejo MT, Martinez M, Tafur M, Castellano VJ
马波沙星及其代谢物n -去甲基-马波沙星在肉鸡体内的药代动力学特征及组织残馀。
美国兽医杂志2002年7月;63(7):927-33。
- PubMed ID
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12118670 (PubMed视图］
- 摘要
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目的:测定马波沙星在鸡体内单次静脉口服后的药代动力学特征和连续每日口服后的组织残留。动物:健康肉鸡40只。实验步骤:两组鸡(A组、B组;每组8只鸡)给予单次静脉注射和口服马波沙星(2 mg/kg)。C组24只鸡连续每天给药2 mg/kg, PO, q 24 h，连续3 d。采用高效液相色谱法测定血浆(A组、B组)和组织(C组)marbo氟沙星及其主要代谢物n -去甲基marbo氟沙星浓度。检测靶组织中marboflo沙星和n -去甲基marboflo沙星的残留量。结果:马波沙星在血浆中的消除半衰期和平均停留时间分别为静脉给药后5.26和4.36 h，口服给药后8.69和8.55 h。最大血药浓度为1.05微克/毫升，从口服到最大血药浓度的间隔时间为1.48小时。口服马波沙星的生物利用度为56.82%。 High concentrations of marbofloxacin and N-desmethyl-marbofloxacin were found in the kidneys, liver, muscles, and skin plus fat 24 hours after the final dose of marbofloxacin; however, marbofloxacin and N-desmethyl-marbofloxacin were detected in only hepatic (27.6 and 98.7 microg/kg, respectively) and renal (39.7 and 69.1 microg/kg, respectively) tissues 72 hours after termination of marbofloxacin treatment. CONCLUSIONS AND CLINICAL RELEVANCE: Analysis of pharmacokinetic data obtained in this study reveals that a minimal therapeutic dose of 2 mg/kg, PO, every 24 hours should be appropriate for control of most infections in chickens.
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