比较tepoxalin、carprofen meloxicam降低眼内炎症的狗。

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吉尔摩,Lehenbauer太瓦

比较tepoxalin、carprofen meloxicam降低眼内炎症的狗。

J兽医研究》2009年7月,70 (7):902 - 7。doi: 10.2460 / ajvr.70.7.902。

PubMed ID

19566476 (在PubMed

]

文摘

目的:比较口头tepoxalin管理的影响,carprofen,狗meloxicam控制aqueocentesis-induced前葡萄膜炎,由测量水的前列腺素E(2)(铂族元素(2))浓度。动物:38的混血狗。程序:狗是分配给一个对照组和3个治疗组。狗在对照组没有得到药物治疗。狗在每个治疗组收到了非甾体抗炎药(tepoxalin, 10毫克/公斤,阿宝,问24小时;carprofen, 2.2毫克/公斤,阿宝,问12 h;或meloxicam, 0.2毫克/公斤,阿宝,问24 h)天0和1。第一天,狗被麻醉,最初aqueocentesis进行双眼;1小时后,第二个aqueocentesis。水在-80摄氏度到化验样本冷冻铂族元素(2)浓度通过酶免疫分析法。 RESULTS: Significant differences between aqueous PGE(2) concentrations in the first and second samples from the control group indicated that aqueocentesis induced uveitis. Median change in PGE(2) concentrations for the tepoxalin group (10 dogs [16 eyes]) was significantly lower than the median change for the control group (8 dogs [16 eyes]), carprofen group (9 dogs [16 eyes]), or meloxicam group (9 dogs [16 eyes]). Median changes in PGE(2) concentrations for dogs treated with meloxicam or carprofen were lower but not significantly different from changes for control dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Tepoxalin was more effective than carprofen or meloxicam for controlling the production of PGE(2) in dogs with experimentally induced uveitis. Tepoxalin may be an appropriate choice when treating dogs with anterior uveitis.

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药物

Tepoxalin