昼夜泰乐菌素的血清浓度在肉鸡饲料或水药物。

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莉莉娅·G·阿奎莱拉R, Cortes-Cuevas,罗萨里奥C, Sumano H

昼夜泰乐菌素的血清浓度在肉鸡饲料或水药物。

Br幼禽Sci。2008年9月,49 (5):619 - 24。doi: 10.1080 / 00071660802357033。

PubMed ID

18836909 (在PubMed

]

文摘

1。因为泰乐菌素是一个依赖于时间的抗菌剂,因为喂养和饮酒的降低肉鸡的下午晚些时候,在黑暗中停止,这是假设,这种药物的血清浓度大大降低黑暗时期。2。试验是在一个商业家禽的房子,在标准肉鸡饲养条件下,提供食物和水从22:00撤回,直到第二天早上07:00 h和暴露的自然光循环13 l: 11 d。3所示。肉鸡酒石酸泰乐菌素,在饲料或水,5 d如下:100年,200年和300年ppm饲料,相当于12.6,25.2和37.8毫克/公斤/天,分别;和200和400毫克/升的饮用水,相当于51到102毫克/公斤/ d,分别。4所示。在d h 07:00 4,在接下来的40小时,每小时获得的血清样本,分析了泰乐菌素的微生物鉴定。5。 Day vs night concentrations of tylosin expressed as area under the curve (AUC) in all groups revealed greater values during the day. The highest AUC and AUC(24)/minimal inhibitory concentration (MIC) ratio were obtained in the group medicated with 400 mg/l and the corresponding lowest values were found in the group medicated with 100 ppm in feed. 6. In conclusion, tylosin did not reach therapeutic serum concentrations during the dark period, at all dose rates tested when administered in feed or water. A sustained release form of this drug is needed to solve this inadequacy of tylosin medication in broilers.

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药物

泰乐菌素