组织残留和尿排泄的zilpaterol羊与膳食zilpaterol治疗10天。

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史密斯搁置西城,DJ

组织残留和尿排泄的zilpaterol羊与膳食zilpaterol治疗10天。

J阿格利司食品化学。2006年6月14日,54 (12):4155 - 61。

PubMed ID

16756341 (在PubMed

]

文摘

Zilpaterol是该项生长促进剂在墨西哥和南非批准用于牛。理解zilpaterol损耗的利率从感兴趣的组织和尿液是开发的策略来检测zilpaterol的标示外使用。八只羊被喂以0.15毫克/公斤/天饮食zilpaterol盐酸盐(Zilmax)连续10天;两只羊都被屠杀0、2、5、9天停药后暴露在zilpaterol-containing饮食。在戒断期组织zilpaterol水平迅速下降。的基础上质/ MS-ES(外部标准)测量,肝脏zilpaterol残留在羊分别为29.3,1.5,0.13,和0.10 ng / g 0后,2、5、9天撤军时间,分别;肾脏残留分别为29.6,1.10和0.09 ng / g和低于检出限;和肌肉残留分别为13.3,0.86,0.12,和0.08 ng / g各自在同一时期撤军。在动物喂养期间尿zilpaterol浓度的变化是相当大的,虽然zilpaterol浓度聚集有些是达到稳定状态。撤军的头3天期间,zilpaterol消除遵循一阶排泄模式,在平均消除半衰期为15.3 + / - 1.8 h。尿zilpaterol浓度戒断期间使用ELISA测定,HPLC-fluorescence,质/ MS-ES(外部标准)和质/毫秒(内部标准)。 Comparison of these methods showed a high correlation with each other. With the exception of LC-MS/MS-IS, the regression coefficients of the linear equations with a zero intercept were between 0.90 and 1.25, indicating the near equivalence of the methods. Because of its simplicity, ELISA is a convenient assay for determining zilpaterol levels in urine giving similar results to HPLC-fluorescence and LC-MS/MS-ES without requiring the extensive cleanup of the latter methods.

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药物

Zilpaterol