双氯芬酸:一个更新其作用机理和安全性。
文章的细节
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引用
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氮化镓TJ
双氯芬酸:一个更新其作用机理和安全性。
咕咕叫地中海Res当今。2010;7月26(7):1715 - 31所示。doi: 10.1185 / 03007995.2010.486301。
- PubMed ID
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20470236 (在PubMed]
- 文摘
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背景:双氯芬酸是一种证明,常用非甾体类抗炎药(非甾体抗炎药),镇痛,抗炎、退热的属性,已被证明可有效地治疗各种急性和慢性疼痛和炎症条件。与所有非甾体抗炎药一样,双氯芬酸对其行动通过抑制前列腺素合成的抑制cyclooxygenase-1 (COX-1)和cyclooxygenase-2相对equipotency (cox - 2)。然而,大量的研究表明双氯芬酸的药理活动超越必威国际app了考克斯抑制,包括多通道和,在某些情况下,小说的作用机理(农业部)。通过PubMed /执行数据源:文献检索MEDLINE(通过2009年5月)使用组合的双氯芬酸、非甾体抗炎药,作用机理,COX-1, cox - 2和药理学。参考文献引用导致的出版物中确定搜索在适当的时候进行了综述。必威国际app方法:本文综述了建立,假定的,双氯芬酸的和新兴的恐鸟;比较了药物的药理学和药效学特性与其他非甾体抗炎药描绘其潜在特有的品质;推测为什么最近被选为进一步制定增强;和评估的潜在影响恐鸟安全特征。讨论:研究表明,双氯芬酸可以必威国际app抑制thromboxane-prostanoid受体,影响花生四烯酸释放和吸收,抑制脂肪氧合酶的酶,并激活氮oxide-cGMP antinociceptive途径。 Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARgamma), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia. The review was not designed to compare MOAs of diclofenac with other NSAIDs. Additionally, as the highlighted putative and emerging MOAs do not have clinical data to demonstrate that these models are correct, further research is necessary to ascertain if the proposed pathways will translate into clinical benefits. The diversity in diclofenac's MOA may suggest the potential for a relatively more favorable profile compared with other NSAIDs.
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- 药物