精氨酸刺激生长激素分泌,抑制内源性生长抑素分泌。

文章的细节

引用

复制到剪贴板

Alba-Roth J,穆勒OA、Schopohl J·冯·云达K

精氨酸刺激生长激素分泌,抑制内源性生长抑素分泌。

中国性金属底座。1988年12月,67 (6):1186 - 9。

PubMed ID

2903866 (在PubMed

]

文摘

来确定精氨酸(Arg)刺激GH分泌,我们调查了其交互GHRH体内和体外。六个四次正常的男性进行了研究:1)Arg-TRH, 30克精氨酸在30分钟在500毫升生理盐水,紧随其后的是注射200微克韦;2)GHRH-Arg-TRH GHRH - 100微克(在美国)有四丸立即注入参数之前,其次是韦200微克,第四;3)GHRH测试,100微克GHRH作为第四丸;和4)韦测试,200微克韦有四丸剂量。收集血液样本在下半场间隔30分钟和120分钟后的输液。垂体前叶细胞从老鼠coincubated Arg(3、6、15、30和60毫克/毫升)和GHRH (0.05、1、5、10 nmol / L)一段3 h。老鼠GH测量介质。后Arg-TRH平均血清GH浓度显著增加从0.6到23.3 + / - 7.3微克/ L (+ / - SE) 60分钟。韦血清TSH、PRL显著增加(最大TSH, 11.1 + / - 1.8亩/ L;最大光杆载荷,74.6 + / - 8.4微克/升)。GHRH-Arg-TRH之后,最大的血清GH水平明显高于(72.7 + / - 13.4微克/升)后比Arg-TRH孤独,而血清TSH、PRL可比水平增加(TSH, 10.2 + / - 3.0亩/ L; PRL, 64.4 +/- 13.6 micrograms/L). GHRH alone increased serum GH to 44.9 +/- 9.8 micrograms/L, significantly less than when GHRH, Arg, and TRH were given. TRH alone increased serum TSH to 6.6 +/- 0.6 mU/L, significantly less than the TSH response to Arg-TRH. The PRL increase after TRH only also was lower (47.2 +/- 6.8 micrograms/L) than the PRL response after Arg-TRH. In vitro Arg had no effect on basal and GHRH-stimulated GH secretion. Our results indicate that Arg administered with GHRH led to higher serum GH levels than did a maximally stimulatory dose of GHRH or Arg alone. The serum TSH response to Arg-TRH also was greater than that to TRH alone. We conclude that the stimulatory effects of Arg are mediated by suppression of endogenous somatostatin secretion.

DrugBank数据引用了这篇文章

药物

精氨酸