马硬膜外给药的蒂勒他明/唑拉西泮。
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Natalini CC, Alves SD, Guedes AG, Polydoro AS, Brondani JT, Bopp S
马硬膜外给药的蒂勒他明/唑拉西泮。
中华兽医杂志，2004,31(2):79-85。
- PubMed ID
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15053744 (PubMed视图］
- 摘要
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目的:评价铁来他明/唑拉西泮硬膜外给药对马镇痛、生理和行为学的影响。研究设计:前瞻性、双盲、随机实验研究。动物:五匹10-16岁、健康的成年马，体重(平均+/-标准差)400 +/- 98公斤。方法:马用1.0 mg kg(-1)静脉注射xylazine (IV)进行镇静，并在第一尾骨间椎间隙放置硬膜外导管。在48小时静息期后，在硬膜外给予0.5 mg kg(-1)(治疗I)或1.0 mg kg(-1)(治疗II)，在无菌水中稀释至5ml，两次治疗之间间隔1周。评估心率、呼吸频率、动脉血压和镇静。为了评估呼吸影响，在时间0时(基线)从颈动脉抽血，然后在60分钟和240分钟后抽血。通过用钝头钳在会阴区域施加有害刺激来评估镇痛效果，并将其分为完全、中度或无疼痛。数据在给药前收集，每隔15分钟收集120分钟，在给药后4小时收集。数据采用方差分析和Bonferroni检验，p < 0.05。 RESULTS: The results showed no significant difference between treatments in cardiovascular and respiratory measurements. Sedation was observed with both doses, and it was significantly different from baseline at 60, 75, and 90 minutes in treatment II. Moderate analgesia and locomotor ataxia were observed with both the treatments. CONCLUSIONS AND CLINICAL RELEVANCE: The results suggest that caudal epidural 0.5 and 1.0 mg kg(-1) tiletamine/zolazepam increases the threshold to pressure stimulation in the perineal region in horses. The use of epidural tiletamine/zolazepam could be indicated for short-term moderate epidural analgesia. There are no studies examining spinal toxicity of Telazol, and further studies are necessary before recommending clinical use of this technique.
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