分布monocarboxylate运输车MCT1-MCT8在老鼠和人类骨骼肌组织。

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Bonen,净化Heynen M H

分布monocarboxylate运输车MCT1-MCT8在老鼠和人类骨骼肌组织。

:杂志减轻金属底座。2006年2月,31 (1):31-9。

PubMed ID

16604139 (在PubMed

]

文摘

在过去的十年里,一个家庭的monocarboxylate转运蛋白(mct)已确定,可能运输乳酸、丙酮酸、酮体和支链ketoacids。目前,14等特定轴是已知的。然而,许多孤儿转运蛋白存在的运输能力仍有待确定。此外,这些特定的组织分布不明确。有时,这种编目可以开始显示某一特定的代谢作用。最近,大量的抗体选择mct (MCT1 2, 4, 5 - 8)已成为商用。因此,我们研究了这些特定的蛋白表达大量的老鼠组织(心脏、骨骼肌、皮肤、脑、睾丸、输精管、脂肪组织,肝、肾、脾、胰腺),以及在人类骨骼肌。出乎意料地,许多组织coexpressed 4 - 5未经中华人民共和国交通部。特别是在大鼠骨骼肌MCT1 MCT2, MCT4 MCT5, MCT6被观察到。在人类肌肉,这些相同的mct在场。 We also observed a pronounced MCT7 signal in human muscle, whereas a very faint signal occurred for MCT8. In rat heart, which is an important metabolic sink for lactate, we confirmed that MCT1 and -2 were expressed. In addition, MCT6 and -8 were also prominently expressed in this tissue, although it is known that MCT8 does not transport aromatic amino acids or lactate. This catalog of MCTs in skeletal muscle and other tissues has revealed an unexpected complexity of coexpression, which makes it difficult to associate changes in monocarboxylate transport with the expression of a particular MCT. The differences in transport kinetics for lactate and pyruvate are only known for MCT1, -2 and -4. Transport kinetics remain to be established for many other MCTs. In conclusion, this study suggests that in skeletal muscle, as well as other tissues, lactate and pyruvate transport rates may not only involve MCT1 and -4, as other monocarboxylate transporters are also expressed in rat (MCT2, -5, -6) and human skeletal muscle (MCT2, -5, -6, -7).

DrugBank数据引用了这篇文章

药物靶点

药物	目标	类	生物	药理作用	行动
丙酮酸	Monocarboxylate运输车2	蛋白质	人类	未知的	不可用	细节
丙酮酸	Monocarboxylate运输车5	蛋白质	人类	未知的	不可用	细节
丙酮酸	Monocarboxylate运输车6	蛋白质	人类	未知的	不可用	细节
丙酮酸	Monocarboxylate运输机7	蛋白质	人类	未知的	不可用	细节
丙酮酸	Monocarboxylate运输车8	蛋白质	人类	未知的	不可用	细节