结合生命起源以前的短期和长链inulin-type果聚糖在青少年提高钙的吸收和骨矿化。

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艾布拉姆斯SA,格里芬IJ,霍桑公里,梁L,耿氏SK,达林顿G,埃利斯KJ

结合生命起源以前的短期和长链inulin-type果聚糖在青少年提高钙的吸收和骨矿化。

是中国减轻。2005年8月,82 (2):471 - 6。

PubMed ID

16087995 (在PubMed

]

文摘

背景:短期研究青少年通常表现出增强的钙质吸收inulin-type果聚糖(益生元)。结果不一致;然而,没有进行研究,以确定这种影响仍然存在长期使用。目的:目的是评估影响钙吸收和骨质增生后8周和1 y的补充inulin-type果聚糖。设计:青春期的青少年被随机分配接受8 g / d混合短期和长期的聚合度inulin-type果聚糖产品(果聚糖组)或麦芽糖糊精安慰剂(对照组)。骨矿含量和骨密度测量随机化之前和之后1 y。钙吸收测量使用稳定同位素在基线和补充后8周和1 y。Fok1维生素D受体基因多态性的确定。结果:钙的吸收明显果聚糖组比对照组在8周(区别:8.5 + / - 1.6%;在1 y (P < 0.001),差异:5.9 + / - 2.8%;P = 0.04)。 An interaction with Fok1 genotype was present such that subjects with an ff genotype had the least initial response to fructan. After 1 y, the fructan group had a greater increment in both whole-body bone mineral content (difference: 35 +/- 16 g; P = 0.03) and whole-body bone mineral density (difference: 0.015 +/- 0.004 g/cm(2); P = 0.01) than did the control group. CONCLUSION: Daily consumption of a combination of prebiotic short- and long-chain inulin-type fructans significantly increases calcium absorption and enhances bone mineralization during pubertal growth. Effects of dietary factors on calcium absorption may be modulated by genetic factors, including specific vitamin D receptor gene polymorphisms.

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