老鼠的海马的微分表达式聚糖训练一个抑制学习范式。

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伊达尔戈,布尔戈斯V,中提琴H,麦地那J, Argibay P

老鼠的海马的微分表达式聚糖训练一个抑制学习范式。

神经病理学。2006年12月,26 (6):501 - 7。

PubMed ID

17203585 (在PubMed

]

文摘

的多糖链glycoconjugates信息和cell-matrix交互中扮演重要的角色。在中枢神经系统,以前的研究学习和记忆建议的重要性低聚糖在glycoconjugates调制的突触连接。我们研究了老鼠的海马多糖分布服从一个抑制性回避的任务。的表达聚糖lectin-histochemistry使用了野豌豆属摘要凝集素(VVL)终端α/βN-acetylgalactosamine(α/βGalNAc);雪花属nivalus凝集素(GNL)终端甘露糖alpha - 3 (alpha -, 3);花生凝集素(机构)半乳糖beta 1,3 n-acetylgalactosamine(加beta 1, 3 GalNAc);刺桐cristagalli为半乳糖凝集素(ECL) beta 1, 4 N-acetylglucosamine(加beta 1, 4 GlcNAc);Sambucus黑质凝集素(SNA)唾液酸α- 2.6半乳糖(SA)α2,6加);Maackia amurensis凝集素II (MAL II)唾液酸α2、3 (SA)α2、3);麦胚凝集素(WGA)终端N-acetylglucosamine有/无唾液酸(GlcNAc SA); succynilated WGA (sWGA) for terminal N-acetylglucosamine without sialic acid (terminal GlcNAc without SA); Griffonia simplicifolia lectin II (GSL II) for terminal alpha/beta N-acetylglucosamine (alpha/beta GlcNAc terminal); and Lotus tetragonolobus lectin (LTL) alpha-fucose. Two groups of 10 animals were examined: non-trained (Control) and Trained rats. ECL, sWGA and GSL II were negative for both groups in all the hippocampal subfields studied. For both groups, VVL was negative in CA4 and granular cells of the Dentate Gyrus (DG) and LTL was negative in the CA4 subfield. Expression of alpha/beta GalNAc, alpha-fucose and GlcNAc in other hippocampal subflields was positive, with no differences between groups. However, expression of Man alpha-1,3 was significantly higher in the CA1, CA2, CA3, and CA4 subfields in the Trained group. On the other hand, expression of Gal beta-1,3 GalNAc was significantly low in CA4 and DG in the Trained group. In conclusion, the results here presented indicate that the exposure of rats to an associative behavioral paradigm related to declarative memory, involves some regulatory mechanism/s for the differential patterns of glycan expression.

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药物靶点

药物	目标	类	生物	药理作用	行动
N-Acetylglucosamine	beta 1, 4-galactosyltransferase 1	蛋白质	人类	未知的	不可用	细节