Thiazolidinediones

Name
Thiazolidinediones
Accession Number
DBCAT002198
Description

A group of oral anti-diabetic drugs designed to treat patients with type 2 diabetes. Thiazolidenediones are compounds that act as agonists of the peroxisome proliferator-activated receptor-gamma increasing tissues sensibility (muscle, adiposity tissue, and liver) to insulin action.

ATC Classification
Drugs
Drug Drug Description
Rosiglitazone A thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes.
Pioglitazone A thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus.
Ciglitazone Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in...
Lobeglitazone Lobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being monitored by postmarketing surveillance until 2019. Lobeglitazone is not approved for use...
Rivoglitazone Rivoglitazone (INN) is a thiazolidinedione undergoing research for use in the treatment of type 2 diabetes. It is being developed by Daiichi Sankyo Co.
Netoglitazone Netoglitazone (MCC-555) is a hypoglycemic agent.
Balaglitazone Balaglitazone has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
Troglitazone For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
Drugs & Drug Targets
Drug Target Type
Rosiglitazone Peroxisome proliferator-activated receptor gamma target
Rosiglitazone Cytochrome P450 2C8 enzyme
Rosiglitazone Cytochrome P450 2C9 enzyme
Rosiglitazone Long-chain-fatty-acid--CoA ligase 4 target
Rosiglitazone Solute carrier organic anion transporter family member 1B1 transporter
Rosiglitazone Prostaglandin G/H synthase 1 enzyme
Rosiglitazone Cytochrome P450 1A2 enzyme
Rosiglitazone Cytochrome P450 2D6 enzyme
Rosiglitazone Serum albumin carrier
Rosiglitazone Peroxisome proliferator-activated receptor alpha target
Rosiglitazone Peroxisome proliferator-activated receptor delta target
Rosiglitazone Retinoic acid receptor RXR-alpha target
Rosiglitazone Retinoic acid receptor RXR-beta target
Rosiglitazone Retinoic acid receptor RXR-gamma target
Rosiglitazone Cytochrome P450 3A4 enzyme
Rosiglitazone Bile salt export pump transporter
Rosiglitazone Cytochrome P450 2B6 enzyme
Rosiglitazone Cytochrome P450 2E1 enzyme
Pioglitazone Peroxisome proliferator-activated receptor gamma target
Pioglitazone Cytochrome P450 2C8 enzyme
Pioglitazone Cytochrome P450 3A4 enzyme
Pioglitazone Solute carrier organic anion transporter family member 1B3 transporter
Pioglitazone Solute carrier organic anion transporter family member 1B1 transporter
Pioglitazone Amine oxidase [flavin-containing] B target
Pioglitazone Serum albumin carrier
Pioglitazone Cytochrome P450 1A1 enzyme
Ciglitazone Peroxisome proliferator-activated receptor gamma target
Ciglitazone Cytochrome P450 3A4 enzyme
Ciglitazone Cytochrome P450 2C8 enzyme
Lobeglitazone Solute carrier organic anion transporter family member 1B1 transporter
Lobeglitazone Solute carrier organic anion transporter family member 3A1 transporter
Lobeglitazone P-glycoprotein 1 transporter
Lobeglitazone Cytochrome P450 1A2 enzyme
Lobeglitazone Cytochrome P450 2C9 enzyme
Lobeglitazone Cytochrome P450 2C19 enzyme
Lobeglitazone Peroxisome proliferator-activated receptor gamma target
Lobeglitazone Cytochrome P450 3A4 enzyme
Lobeglitazone Cytochrome P450 2C8 enzyme
Rivoglitazone Cytochrome P450 3A4 enzyme
Rivoglitazone Cytochrome P450 2C8 enzyme
Netoglitazone Cytochrome P450 3A4 enzyme
Netoglitazone Cytochrome P450 2C8 enzyme
Balaglitazone Cytochrome P450 3A4 enzyme
Balaglitazone Cytochrome P450 2C8 enzyme
Troglitazone Peroxisome proliferator-activated receptor gamma target
Troglitazone Long-chain-fatty-acid--CoA ligase 4 target
Troglitazone Plasminogen activator inhibitor 1 target
Troglitazone Equilibrative nucleoside transporter 1 target
Troglitazone Cytochrome P450 3A4 enzyme
Troglitazone Cytochrome P450 2C19 enzyme
Troglitazone UDP-glucuronosyltransferase 1-1 enzyme
Troglitazone Cytochrome P450 2C8 enzyme
Troglitazone Bile salt export pump transporter
Troglitazone Solute carrier organic anion transporter family member 1B1 transporter
Troglitazone Estrogen-related receptor gamma target
Troglitazone Steroid hormone receptor ERR1 target
Troglitazone Cytochrome P450 19A1 enzyme
Troglitazone Cytochrome P450 1A1 enzyme
Troglitazone Cytochrome P450 2B6 enzyme
Troglitazone Cytochrome P450 2C9 enzyme
Troglitazone Cytochrome P450 3A5 enzyme
Troglitazone Cytochrome P450 3A7 enzyme
Troglitazone UDP-glucuronosyltransferase 1-3 enzyme
Troglitazone UDP-glucuronosyltransferase 1-4 enzyme
Troglitazone UDP-glucuronosyltransferase 1-6 enzyme
Troglitazone UDP-glucuronosyltransferase 1-7 enzyme
Troglitazone UDP-glucuronosyltransferase 1-8 enzyme
Troglitazone UDP-glucuronosyltransferase 1-9 enzyme
Troglitazone UDP-glucuronosyltransferase 1-10 enzyme
Troglitazone UDP-glucuronosyltransferase 2B7 enzyme
Troglitazone UDP-glucuronosyltransferase 2B15 enzyme
Troglitazone Peroxisome proliferator-activated receptor delta target
Troglitazone Peroxisome proliferator-activated receptor alpha target
Troglitazone Glutathione S-transferase P target