Miscellaneous GI Drugs

Name
Miscellaneous GI Drugs
Accession Number
DBCAT003746
Description

Not Available

Drugs
Drug Drug Description
Lubiprostone A prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
Orlistat A reversible inhibitor of gastrointestinal lipases indicated for weight loss and weight maintenance.
Obeticholic acid A bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA.
Prucalopride A 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation.
Methylnaltrexone A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
Linaclotide A guanylate cyclase-C agonist used to treat constipation associated with irritable bowel syndrome or that is idiopathic in nature.
Teduglutide A glucagon-like peptide-2 (GLP-2) analog used to treat patients with Short Bowel Syndrome (SBS) who require parenteral nutritional support.
Naloxegol A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
Pinaverium A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
Sodium citrate An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.
Eluxadoline A mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea.
Adalimumab A monoclonal anti-tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis.
Vedolizumab An integrin blocker and anti-inflammatory agent used to manage ulcerative colitis and Crohn's disease in adults with inadequate clinical response to immunomodulators.
Plecanatide A laxative used to treat chronic idiopathic constipation and IBS with constipation.
Drugs & Drug Targets
Drug Target Type
Lubiprostone Chloride channel protein 2 target
Lubiprostone Carbonyl reductase [NADPH] 1 enzyme
Orlistat Pancreatic triacylglycerol lipase target
Orlistat Fatty acid synthase target
Orlistat Gastric triacylglycerol lipase target
Orlistat Cytochrome P450 3A4 enzyme
Orlistat Cytosolic phospholipase A2 enzyme
Orlistat Serum albumin carrier
Orlistat Fatty acid synthase enzyme
Obeticholic acid Bile acid receptor target
Obeticholic acid Cytochrome P450 1A2 enzyme
Obeticholic acid Bile salt export pump transporter
Prucalopride 5-hydroxytryptamine receptor 4 target
Prucalopride Cytochrome P450 3A4 enzyme
Prucalopride Serum albumin carrier
Prucalopride P-glycoprotein 1 transporter
Methylnaltrexone Mu-type opioid receptor target
Methylnaltrexone Kappa-type opioid receptor target
Linaclotide Heat-stable enterotoxin receptor target
Teduglutide Glucagon-like peptide 2 receptor target
Naloxegol Cytochrome P450 3A4 enzyme
Naloxegol Cytochrome P450 2D6 enzyme
Naloxegol Cytochrome P450 2C19 enzyme
Naloxegol Mu-type opioid receptor target
Pinaverium Voltage-dependent L-type calcium channel subunit alpha-1S target
Pinaverium Cytochrome P450 3A4 enzyme
Sodium citrate Mitochondrial 2-oxodicarboxylate carrier transporter
Sodium citrate Solute carrier family 13 member 2 transporter
Sodium citrate Solute carrier family 13 member 5 transporter
Sodium citrate Tricarboxylate transport protein, mitochondrial transporter
Eluxadoline Mu-type opioid receptor target
Eluxadoline Delta-type opioid receptor target
Eluxadoline Kappa-type opioid receptor target
Eluxadoline Solute carrier organic anion transporter family member 1B1 transporter
Eluxadoline Canalicular multispecific organic anion transporter 1 transporter
Eluxadoline Solute carrier family 22 member 8 transporter
Adalimumab Tumor necrosis factor target
Vedolizumab Integrin alpha-4 target
Vedolizumab Integrin beta-7 target
Plecanatide Guanylate cyclase soluble subunit alpha-2 target