NAV

Pyrithione

Identification

Summary

Pyrithioneis an antimicrobial agent used for the treatment of dandruff and seborrheic dermatitis.

Brand Names
Biokera
Generic Name
Pyrithione
DrugBank Accession Number
DB06815
Background

Pyrithione zinc, or zinc pyrithione or zinc pyridinethione, is a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. In the crystalline state, it exists as a centrosymmetric dimer. Due to its dynamic fungistatic and bacteriostatic properties, pyrithione zinc is used to treat dandruff and seborrheic dermatitis. Dandruff is a common scalp disease affecting >40% of the world's adult population, and may be caused by fungi such asMalassezia globosaandM. restricta3.

Pyrithione zinc is commonly found as an active ingredient in OTC antidandruff topical treatments such as shampoos. It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth1. Due to low solubility, pyrithione zinc released from the topical formulations is deposited and retained relatively well onto the target skin surfaces2. Other uses of pyrithione zinc include additive in antifouling outdoor paints and algaecide. While its use has been approved in the early 1960's by the FDA4, safety and effectiveness of pyrithione zinc has been reported for decades. It is not shown to have any significant estrogenic activity according to thein vivoandin vitroassays4.

Type
Small Molecule
Groups
Approved
Structure
MOL SDF PDB SMILES InChI
Similar Structures
Weight
Average: 127.16
Monoisotopic: 127.009184959
Chemical Formula
C5H5NOS
Synonyms
  • 2-pyridinethiol 1-oxide
  • Omadine
  • Pyridinethiol N-oxide
External IDs
  • NSC-290409

Pharmacology

Indication

Indicated for the treatment of dandruff and seborrheic dermatitis2.

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Pyrithione zinc has a broad antimicrobial spectrum of activity, including fungi, gram-positive and gram-negative bacteria2. Pyrithione zinc is effective against Malassezia and all other fungi, especially the Malassezia species found on scalp5. In patients with dandruff, treatment with pyrithione zinc reduced the amount of fungus on the scalp, which reduces the amount of free fatty acids, thereby reducing scalp flaking and itch5.

Mechanism of action

Inhibition of fungal growth by pyrithione zinc is linked to increased copper uptake and cellular levels of copper, which is demonstrated by decreased CTR1-lacZ expression and slightly increased CUP1-lacZ expression in affected microorganisms3. The coordination complex of pyrithione zinc dissociates, and pyrithione ligand forms a CuPT complex from available extracellular copper in the target organism. Pyrithione acts as an ionophore, interacting nonspecifically with the plasma membrane to shuttle copper into the cell, and facilitates copper transport across intracellular membranes3. Copper may be shuttled into the mitochondria. Copper inactivates iron-sulfur (Fe-S) cluster-containing proteins via a mechanism similar to that described for copper-induced growth inhibition in bacteria3. Decreased activity of Fe-S proteins leads to inhibition of fungal metabolism and fungal growth. Pyrithione zinc has been shown to slightly increase the levels of zinc3.

Absorption

Following oral ingestion, only the pyrithione moiety is absorbed. Less than 1% of administered zinc pyrithione is absorbed from the skin6. Radioabeled Zn pyrithione administered to rats, rabbits and monkeys, either orally or via intraperitoneal injection were absorbed into circulatin to extent of 80-90%6.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

After oral administration in rabbits, rats, monkeys, and dogs, pyrithione zinc is biotransformed into 2-pyridinethiol 1-oxide S-glucuronide and 2-pyridinethiol S-glucuronide6.

Route of elimination

The major route of elimination from the body after oral administration in rat was urine, with S-glucuronides of 2-mercaptopyridine-N-oxide being the major metabolites and 2-mercaptopyridine-N-oxide as the minor metabolite. Following oral administration, the majority of zinc is eliminated in the feces6. Upon dermal administration, >90% of recovery was obtained from washings of the application site of pigs. Urinary excretion was 3% in animals with intact skin6.

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Acute oral LD50 value is 177 mg/kg in rat and 160 mg/kg in mouse. Acute dermal LD50 was 100 mg/kg in rabbitMSDS.

Pathways
Not Available
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Interactions

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这些信息不应该被解释the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction
整合药物之间
interactions in your software
Abacavir Abacavir may decrease the excretion rate of Pyrithione which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Pyrithione which could result in a higher serum level.
Acemetacin Acemetacin may decrease the excretion rate of Pyrithione which could result in a higher serum level.
Acenocoumarol The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Pyrithione.
Acetaminophen Acetaminophen may decrease the excretion rate of Pyrithione which could result in a higher serum level.
Acetazolamide Acetazolamide may increase the excretion rate of Pyrithione which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Pyrithione which could result in a higher serum level.
Aclidinium Pyrithione may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine Pyrithione may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Pyrithione which could result in a higher serum level.
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Food Interactions
No interactions found.

Products

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Product Ingredients
Ingredient UNII CAS InChI Key
Pyrithione sodium 6L3991491R 3811-73-2 WNGMMIYXPIAYOB-UHFFFAOYSA-M
Pyrithione zinc R953O2RHZ5 13463-41-7 OTPSWLRZXRHDNX-UHFFFAOYSA-L
Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image
2 In 1 Shampoo 10.4 mg/1mL Topical TARGET Corporation 2013-05-16 Not applicable US flag
2 In 1 Shampoo 10.3 mg/1mL Topical TARGET Corporation 2013-05-06 Not applicable US flag
2 In 1 Shampoo 10.3 mg/1mL Topical Wal-Mart Stores, Inc 2012-07-12 Not applicable US flag
2 In 1 Shampoo 10 mg/1mL Topical Lidl Us Llc 2021-08-12 Not applicable US flag
2 in 1 anti-Dandruff Shampoo 10 mg/1mL Topical Spa Dent Inc 2021-07-20 Not applicable US flag
2 In 1 Anti-dandruff Shampoo and Conditioner Lotion 1 % Topical Avon Products, Inc. 2003-10-09 2010-07-30 Canada flag
2 in 1 Antidandruff Shampoo 10 mg/1mL Topical Apollo Health and Beauty Care Inc. 2017-03-29 Not applicable US flag
2 In 1 Conditioning Dandruff Shampoo Shampoo 1 % Topical Scott Chemical Canada 2000-01-01 2005-09-16 Canada flag
2 In 1 Conditioning Dandruff Treatment Shampoo Shampoo 1 % Topical Apollo Health and Beauty Care Inc. 2002-10-30 2011-07-07 Canada flag
2 in 1 Dandruff Shampoo 10 mg/1mL Topical Vi-Jon, LLC 2005-06-23 Not applicable US flag
Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
574H Cell Care Pyrithione zinc(3.0 g/300mL)+Biotin(0.18 g/300mL)+Nicotinamide(0.9 g/300mL)+Panthenol(1.5 g/300mL) Shampoo Topical Celino Inc. 2020-06-01 Not applicable US flag
Actiprep Pyrithione zinc(1 %)+Ethanol(83 %) Liquid Topical Healthpoint 2002-09-12 2004-07-13 Canada flag
Add More Hair Pyrithione zinc(0.29 g/100mL)+Panthenol(0.5 g/100mL)+Salicylic acid(0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2017-03-01 2018-09-04 US flag
Add More Hair Pyrithione zinc(0.28 g/100mL)+Panthenol(0.5 g/100mL)+Salicylic acid(0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2018-06-09 2018-09-05 US flag
Anti Hair Loss Pyrithione zinc(2.1 g/100g)+Biotin(0.06 g/100g) Soap Topical Golden B America, Llc. 2018-03-13 Not applicable US flag
Antibacterial Hand Sanitizer Pyrithione zinc0.15 (1/1001)+Sodium chloride(0.8 1/1001)+Sodium hydroxide(0.03 1/1001) Liquid Topical SHANTOU WBM TRADING CO., LTD. 2020-03-19 Not applicable US flag
Antibacterial Hand Sanitizer Pyrithione zinc0.15 (1/1001)+Sodium chloride(0.8 1/1001)+Sodium hydroxide(0.03 1/1001) Liquid Topical SHANTOU WBM TRADING CO., LTD. 2020-03-19 Not applicable US flag
Bonnoir Hair Medi Pyrithione zinc(7.35 mL/350mL)+Biotin(0.21 mL/350mL)+Nicotinamide(1.05 mL/350mL)+Panthenol(1.75 mL/350mL) Shampoo Topical Cellinbio Co Ltd 2011-07-27 Not applicable US flag
Bonogen hair care shampoo Pyrithione zinc(2.1 g/100g)+Biotin(0.06 g/100g)+Nadide(0.3 g/100g)+Panthenol(0.5 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-03-01 Not applicable US flag
Bonogen Plus hair care shampoo Pyrithione zinc(2.1 g/100g)+Biotin(0.06 g/100g)+Nadide(0.3 g/100g)+Panthenol(0.6 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US flag
Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
574H Cell Care Pyrithione zinc(3.0 g/300mL)+Biotin(0.18 g/300mL)+Nicotinamide(0.9 g/300mL)+Panthenol(1.5 g/300mL) Shampoo Topical Celino Inc. 2020-06-01 Not applicable US flag
Add More Hair Pyrithione zinc(0.29 g/100mL)+Panthenol(0.5 g/100mL)+Salicylic acid(0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2017-03-01 2018-09-04 US flag
Add More Hair Pyrithione zinc(0.28 g/100mL)+Panthenol(0.5 g/100mL)+Salicylic acid(0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2018-06-09 2018-09-05 US flag
Anti Hair Loss Pyrithione zinc(2.1 g/100g)+Biotin(0.06 g/100g) Soap Topical Golden B America, Llc. 2018-03-13 Not applicable US flag
Bonnoir Hair Medi Pyrithione zinc(7.35 mL/350mL)+Biotin(0.21 mL/350mL)+Nicotinamide(1.05 mL/350mL)+Panthenol(1.75 mL/350mL) Shampoo Topical Cellinbio Co Ltd 2011-07-27 Not applicable US flag
Bonogen hair care shampoo Pyrithione zinc(2.1 g/100g)+Biotin(0.06 g/100g)+Nadide(0.3 g/100g)+Panthenol(0.5 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-03-01 Not applicable US flag
Bonogen Plus hair care shampoo Pyrithione zinc(2.1 g/100g)+Biotin(0.06 g/100g)+Nadide(0.3 g/100g)+Panthenol(0.6 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US flag
Born Hair Pyrithione zinc(2.1 g/100g)+Biotin(0.06 g/100g)+Nadide(0.3 g/100g)+Panthenol(0.6 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US flag
Carione Rg Pyrithione zinc(2.1 g/100mL)+Biotin(0.06 g/100mL)+Nicotinamide(0.3 g/100mL)+Panthenol(0.5 g/100mL) Shampoo Topical Cell Activation Research Institute Co., Ltd 2016-07-31 Not applicable US flag
Doll Lash Pyrithione zinc(2 mL/100mL)+Biotin(0.06 mL/100mL)+Nicotinamide(0.3 mL/100mL)+Panthenol(0.5 mL/100mL) Liquid Topical Hanbit Korea 2010-11-06 Not applicable US flag

Categories

ATC Codes
D11AX12 — Pyrithione zinc
Drug Categories
Classification
Not classified
Affected organisms
  • Yeast and other fungi

Chemical Identifiers

UNII
6GK82EC25D
CAS number
1121-31-9
InChI Key
FGVVTMRZYROCTH-UHFFFAOYSA-N
InChI
InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,8H
IUPAC Name
2-sulfanylpyridin-1-ium-1-olate
SMILES
[O-][N+]1=C(S)C=CC=C1

References

Synthesis Reference

Schwartz JR: Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics. J Drugs Dermatol. 2016 Feb;15(2):140-4.
一般参考ences
  1. Reeder NL, Xu J, Youngquist RS, Schwartz JR, Rust RC, Saunders CW: The antifungal mechanism of action of zinc pyrithione. Br J Dermatol. 2011 Oct;165 Suppl 2:9-12. doi: 10.1111/j.1365-2133.2011.10571.x. [Article]
  2. Schwartz JR: Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics. J Drugs Dermatol. 2016 Feb;15(2):140-4. [Article]
  3. 里德问,卡普兰J,徐J,扬奎斯特RS,华莱士J, Hu P, Juhlin KD, Schwartz JR, Grant RA, Fieno A, Nemeth S, Reichling T, Tiesman JP, Mills T, Steinke M, Wang SL, Saunders CW: Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins. Antimicrob Agents Chemother. 2011 Dec;55(12):5753-60. doi: 10.1128/AAC.00724-11. Epub 2011 Sep 26. [Article]
  4. Yoon KS, Youn N, Gu H, Kwack SJ: Estrogenic activity of zinc pyrithione: an in vivo and in vitro study. Environ Health Toxicol. 2017 Feb 9;32:e2017004. doi: 10.5620/eht.e2017004. eCollection 2017. [Article]
  5. DeAngelis YM, Gemmer CM, Kaczvinsky JR, Kenneally DC, Schwartz JR, Dawson TL Jr: Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity. J Investig Dermatol Symp Proc. 2005 Dec;10(3):295-7. doi: 10.1111/j.1087-0024.2005.10119.x. [Article]
  6. Pyrithione zinc - National Library of Medicine HSDB Database - Toxnet [Link]
  7. NPRA Product Information: Dezor Plus (zinc pyrithione/ketoconazole) topical shampoo [Link]
PubChem Compound
26041
PubChem Substance
347827800
ChemSpider
10446934
BindingDB
50366038
RxNav
35100
ChEBI
36584
ChEMBL
CHEMBL1356238
ZINC
ZINC000000156822
Wikipedia
Pyrithione_zinc
MSDS
Download (57 KB)

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
4 Completed Treatment Hyperpigmentation 1
4 Recruiting Treatment Atopic Dermatitis 1
4 Unknown Status Treatment Quality of Life (QOL)/Seborrheic Dermatitis 1
3 Terminated Treatment Atrophic Vaginitis 1
0 Completed Basic Science Rosacea 1
Not Available Completed Treatment Fungal Infection in Perineal Area/Moisture-associated Dermatitis 1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Form Route Strength
Shampoo Topical 10.3 mg/1mL
Shampoo Topical 1.2 %
Lotion Topical 0.1 % w/w
Lotion Topical 0.15 mL/150mL
Shampoo Topical 0.15 g/1mL
Soap Topical 2 g/1000g
Solution Topical 20 mg/1mL
Shampoo Cutaneous 0.01 mg/1mL
Shampoo Cutaneous 10 mg/1mL
Soap Topical
Shampoo Topical 0.05 g/100g
Shampoo Topical 2.0 %
Shampoo Topical 1 % w/v
Shampoo Topical 10 mg/1000mg
Shampoo Topical 20 mg/1mL
Emulsion Topical 10 mg/1g
Shampoo Topical 10 mg/1mL
Lotion Topical 2.14 mg/1mL
Shampoo Topical 2.14 mg/1mL
Shampoo Topical 10.32 mg/1mL
Cream Topical 2.14 mg/1mL
Liquid Topical 0.2 %
Shampoo Topical 10.2 mg/1mL
Liquid Topical 10.2 mg/1mL
Liquid Topical 4.9 mg/1mL
Cream Topical 0.2 g/100g
Liquid; shampoo Topical 1 %
Shampoo Topical 2.3 g/230g
Shampoo Topical 1.05 g/100mL
Lotion / shampoo Topical .1 g/10g
Lotion / shampoo Topical .5 g/10g
Lotion / shampoo Topical 1 g/10g
Shampoo Topical 4.5 mL/300mL
Spray Topical 0.19 mg/1mL
Cream Topical 0.2 mg/1g
Cream Topical 0.2 mg/1mL
Shampoo Topical
Cream Topical .1 %
Shampoo Topical 5.7 g/285mL
Shampoo Topical 5.8 mg/290mL
Gel Topical 0.1 %
Suspension Topical 0.5 g/100mL
Shampoo Topical 1.0 g/100mL
Solution Topical 0.1 % w/w
Shampoo, suspension Topical 20 mg/1mL
Shampoo Topical 0.5 g/100mL
Lotion Topical 0.0036 mg/1mL
Liquid Topical 15 g/300mL
Kit Nasal; Topical
Shampoo Topical 0.003 g/1mL
Shampoo Cutaneous 3 g/300g
Shampoo Topical 2 %
Lotion Topical 10 mg/1g
Shampoo Topical 20 mg/1g
Shampoo Topical 1 mg/1mL
Shampoo Topical 1 kg/100L
Shampoo Topical 1.0 % w/w
Shampoo Topical 1.9 g/100mL
Shampoo Topical 10.0 mg/100mL
Shampoo Topical 10.4 mg/1mL
Shampoo Topical 100 g/1mL
Shampoo, suspension Topical 958 mg/1mL
Lotion / shampoo Topical 1.0000 mL/100mL
Suspension Topical 0.5 % w/w
Lotion / shampoo Topical 0.500 mL/100mL
Cream Topical 1 % w/w
Cream Topical 1 %
Shampoo Topical 1.45 %
Lotion / shampoo Topical 1 kg/100L
Suspension Topical 1 %
Lotion Topical 1 % w/w
Lotion Topical 1.0 % w/w
Suspension Topical 1.0 %
Gel Topical 2.0 g/100mL
Soap Topical 1 g/100g
Cream Topical 0.25 g/100mL
Cream Topical 0.25 g/100g
Spray Topical 0.25 g/100mL
Cream Topical 2.5 mg / g
Shampoo Topical 20 mg / g
Spray Topical 0.25 %
Shampoo Topical 1.65 g/100ml
Solution Topical 0.95 g/100g
Liquid Topical
Cream Topical 1 mg/1mL
Liquid Topical 0.5 g/100mL
Shampoo Topical 2.4 g/500g
Shampoo Topical 14 mg/1mL
Shampoo Topical 1.2 g/100g
Shampoo Topical 12 g/1L
Solution Topical 2.4 mg/500mL
Solution Topical 0.09 g/100mL
Shampoo Topical 1.2 g/100mL
Shampoo Topical 10 mL/1000mL
Shampoo Topical 65.7 g/1000mL
Shampoo Topical 300 mg/100mL
Liquid Topical 3 mg/1mL
Liquid Topical 0.05 g/1mL
Shampoo Topical 5.28 mg/1mL
Liquid Topical 0.0036 mg/1mL
Liquid Topical 0.00528 g/1mL
Liquid Topical 0.011 mg/1mL
Liquid Topical 0.0034 mg/1mL
Shampoo Topical 1.0 g / 100 g
Shampoo Topical 10 mg/10mL
Shampoo Topical 1 g/100mL
Lotion / shampoo Topical 0.02 kg/1kg
Shampoo Topical 0.000048 g/100mL
Shampoo Topical 1.008 g/100mL
Shampoo Topical 1.8 mg/300mL
Shampoo Topical 2 g/100mL
Shampoo Topical 1 kg/100kg
Shampoo Topical 12 mg/1mL
Shampoo Topical 2.5 g/250g
Lotion Topical 1 %
Shampoo Topical 1.68 %
Shampoo Topical 6 mg/300mL
Shampoo Topical 6.4 g/320mL
Shampoo Topical 0.1 mL/100mL
Solution Topical 0.1 mL/100mL
Shampoo Topical 0.0095 g/1mL
Shampoo Topical 0.75 % w/w
Shampoo Topical 0.5 %
Shampoo Topical 0.5 % w/w
Cream Topical 0.75 % w/w
Lotion / shampoo Topical 0.01 mg/1mg
Lotion / shampoo Topical 10 mg/1mL
Lotion Topical 0.75 g/100mL
Cream Topical 0.2 g/100mL
Lotion Topical 0.2 g/100mL
Liquid Topical 0.1 g/100mL
Lotion / shampoo Topical 0.5 g/1mL
Lotion Topical 0.5 g/100mL
Lotion Topical 5 mg/1mL
Kit; lotion; shampoo Topical
Kit; lotion; lotion / shampoo Topical
Lotion / shampoo Topical 2 g/100mL
Lotion / shampoo Topical 20 mg/1mL
Paste Topical 0.1 g/100g
Lotion / shampoo Topical 1 g/1mL
Shampoo Topical 0.01 g/1mL
Lotion Topical 0.5 mg/100mL
Lotion / shampoo Topical 1 g/100mL
Lotion / shampoo Topical .01 g/1mL
Lotion / shampoo Topical 0.01 g/1mL
Cream Topical 0.1 g/100mL
Cream Topical 0.5 g/100mL
Lotion Topical 0.1 g/100g
Lotion Topical 0.1 g/100mL
Lotion Topical 1 g/100mL
Cream Topical 0.1 g/100g
Gel Topical 0.1 g/100mL
Cream Topical 1 g/100mL
Lotion / shampoo Topical 7.5 mg/1mL
Shampoo Topical 1.5 g/100g
Shampoo Topical 15 mg/1mL
Emulsion Topical 1.0 g/100g
Shampoo Topical 15.4 g/1L
Shampoo Topical 0.1 % w/w
Shampoo Topical 1.1 g/100g
Shampoo Topical 1.0 g/100g
Shampoo Topical 1.8 %
Liquid Topical 1 g/100mL
Lotion Topical 2 mg/1mL
Shampoo Topical 1.5 %
Liquid Topical 2.1 g/100mL
Shampoo Topical 0.00336 g/1mL
Shampoo Topical 1 %
Shampoo Topical 0.3 mg/100mL
Shampoo Topical 0.3 g/100mL
Shampoo Topical .01 g/1g
Shampoo, suspension Topical .01 g/1g
Shampoo Topical 1.8 g/100mL
Shampoo Topical 15.0 g/1.0L
Shampoo Topical 3.0 g/300g
Shampoo Topical 1.008 g / 100 g
Lotion Topical 10 mg/1mL
Shampoo Topical 1.20000 mg/240mL
Shampoo Topical 10.5 mg/1mL
Shampoo Topical 2.52000 mg/240mL
Shampoo Topical 1 g/100g
Shampoo Topical 0.2 % w/w
Shampoo Topical 10.0 g/500mL
Shampoo Topical 1.5克/ 500毫升
Gel Topical 0.48 g/100mL
Kit Topical
Lotion / shampoo Topical 1 mg/1mL
Liquid Topical 0.97 mg/1mL
Lotion / shampoo Topical 0.1 g/100mL
Solution Topical 0.1 %
Cream Topical 1 mL/100mL
Shampoo Topical 1 g/1mL
Liquid Topical 20 mg/1mL
Liquid Topical 1 %
Liquid Topical 1.0 %
Gel Topical 2.0 g/100g
Shampoo Topical 4.04 g/400mL
Shampoo, suspension Topical 1 g/100mL
Shampoo, suspension Topical 0.45 mL/100mL
Shampoo, suspension Topical 1 mL/100mL
Lotion Topical 0.5 % w/w
Shampoo Topical 1 mg/100mL
Cream Topical 3 mg/1000mL
Cream Topical 2 g/100g
Liquid Topical 29 mg/1mL
Shampoo Topical 2.41 g/237mL
Gel Topical 1 % w/w
Shampoo Topical 1.0 %
Shampoo Cutaneous 0.6 mL/360mL
Shampoo Topical 2.1 g/100mL
Shampoo Topical 1 mL/100mL
Liquid Topical 10 mg/1mL
Liquid Topical 1 mL/100mL
Liquid Topical 1.0 mL/100mL
Cream Topical 9.5 mg/1mL
Shampoo Topical 0.95 %
Shampoo Topical 1.9 %
Shampoo Topical 0.95 % w/w
Shampoo Topical 9.5 mg/1mL
Shampoo Topical 5.0 g/500mL
Shampoo Topical 1 % w/w
Shampoo Topical 5 g/250g
Shampoo Topical 10 mg/1g
Shampoo Topical 3 mg/300mL
Solution Topical 0.95 g/100mL
Aerosol Topical 2 mg / mL
Shampoo Topical 0.3 % w/w
Shampoo Topical 6 mg/1mL
Shampoo Topical 1 g / 100 g
Suspension Topical 0.25 %
Shampoo Topical 0.5 mL/100mL
Shampoo Topical 1.0 mL/100mL
Suspension Topical 0.5 mL/100mL
Cream Topical 1 mg/1g
Shampoo, suspension Topical 10 mg/1mL
Lotion Topical 1 mg/1mL
Cream Topical 0.1 % w/w
Lotion / shampoo Topical 1.2 g/1mL
Shampoo Topical .01 g/.01g
Rinse Topical .005 g/1g
Rinse Topical 1 g/100mL
Rinse Topical 5 mg/1mL
Cream Topical 0.125 g/100mL
Lotion Topical
Shampoo Topical 10 g / kg
Shampoo Topical 2% w / w
Soap Topical 2 g/100g
Shampoo Topical 5 g/500g
Cream Topical 250 mg/100g
Liquid Topical .15 %
Lotion / shampoo Topical 300 mg/100mL
Liquid Topical 5 g/1000g
Shampoo Topical 2 g/100g
Lotion / shampoo Topical 20 mg/400mg
Shampoo Topical 20 mg/400mg
Shampoo Topical 2.98 g/300mL
Suspension Topical 2 %
Gel Topical 1 g/100g
Shampoo Topical 20 mg/2mL
Liquid Topical 2 g/100mL
Cream Topical 0.2 %
Spray Topical 0.2 %
Suspension Topical 100 g
Soap Topical 0.020 g/1
Soap Topical 2 %
Cream Topical .5 %
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Property Value Source
boiling point (°C) 100 (Zinc salt) MSDS
water solubility Soluble in cold water (Zinc salt) MSDS
Predicted Properties
Property Value Source
Water Solubility 3.0 mg/mL ALOGPS
logP 0.87 ALOGPS
logP 0.2 Chemaxon
logS -1.6 ALOGPS
pKa (Strongest Acidic) 6.84 Chemaxon
pKa (Strongest Basic) 0.66 Chemaxon
Physiological Charge -1 Chemaxon
Hydrogen Acceptor Count 1 Chemaxon
Hydrogen Donor Count 1 Chemaxon
Polar Surface Area 26.94 Å2 Chemaxon
Rotatable Bond Count 0 Chemaxon
Refractivity 34.48米3·mol-1 Chemaxon
Polarizability 12.19 Å3 Chemaxon
Number of Rings 1 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter No Chemaxon
Veber's Rule Yes Chemaxon
MDDR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at September 14, 2010 16:21 / Updated at January 16, 2023 09:34