NAV

Ditazole

Identification

Generic Name
Ditazole
DrugBank Accession Number
DB08994
Background

Ditazole is a non-steroidal anti-inflammatory drug (NSAID). Ditazole's analgesic and antipyretic effects are similar to phenylbutazone. Additionally, ditazole is a platelet aggregation inhibitor marketed in Spain and Portugal with trade name Ageroplas.

Type
Small Molecule
Groups
Experimental, Withdrawn
Structure
 3D
Similar Structures
Weight
Average: 324.3737
Monoisotopic: 324.147392516
Chemical Formula
C19H20N2O3
Synonyms
  • 2,2'-(4,5-Diphenyloxazol-2-ylazanediyl)diethanol
  • Ditazole
External IDs
  • S-222

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction
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Abciximab The risk or severity of bleeding can be increased when Abciximab is combined with Ditazole.
Aceclofenac The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Ditazole.
Acemetacin The risk or severity of bleeding and hemorrhage can be increased when Ditazole is combined with Acemetacin.
Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Ditazole.
Acetylsalicylic acid Acetylsalicylic acid may increase the anticoagulant activities of Ditazole.
Albutrepenonacog alfa The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Ditazole.
Alclofenac The risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Ditazole.
Aldesleukin The risk or severity of bleeding can be increased when Ditazole is combined with Aldesleukin.
Alemtuzumab The risk or severity of bleeding can be increased when Ditazole is combined with Alemtuzumab.
Alteplase The risk or severity of bleeding can be increased when Alteplase is combined with Ditazole.
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Food Interactions
  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Products

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International/Other Brands
Ageroplas (Farma Lepori)

Categories

ATC Codes
B01AC01 — Ditazole
Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as phenyl-1,3-oxazoles. These are aromatic heterocyclic compounds containing a 1,3-oxazole substituted at one or more positions by a phenyl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Azoles
Sub Class
Oxazoles
Direct Parent
Phenyl-1,3-oxazoles
Alternative Parents
Dialkylarylamines/2,4,5-trisubstituted oxazoles/Benzene and substituted derivatives/Heteroaromatic compounds/Oxacyclic compounds/Azacyclic compounds/Alkanolamines/Primary alcohols/Organopnictogen compounds/Hydrocarbon derivatives
Substituents
2,4,5-trisubstituted 1,3-oxazole/Alcohol/Alkanolamine/Aromatic heteromonocyclic compound/Azacycle/Benzenoid/Dialkylarylamine/Heteroaromatic compound/Hydrocarbon derivative/Monocyclic benzene moiety
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
H2BQI5Z8FT
CAS number
18471-20-0
InChI Key
UUCMDZWCRNZCOY-UHFFFAOYSA-N
InChI
InChI=1S/C19H20N2O3/c22-13-11-21(12-14-23)19-20-17(15-7-3-1-4-8-15)18(24-19)16-9-5-2-6-10-16/h1-10,22-23H,11-14H2
IUPAC Name
2-[(4,5-diphenyl-1,3-oxazol-2-yl)(2-hydroxyethyl)amino]ethan-1-ol
SMILES
OCCN(CCO)C1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1

References

一般References
Not Available
KEGG Drug
D07138
PubChem Compound
29088
PubChem Substance
310264955
ChemSpider
27061
ChEBI
135383
ChEMBL
CHEMBL2104306
Drugs.com
Drugs.com Drug Page
Wikipedia
Ditazole

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 0.146 mg/mL ALOGPS
logP 2.86 ALOGPS
logP 2.93 Chemaxon
logS -3.4 ALOGPS
pKa (Strongest Acidic) 15.27 Chemaxon
pKa (Strongest Basic) -0.12 Chemaxon
Physiological Charge 0 Chemaxon
Hydrogen Acceptor Count 4 Chemaxon
Hydrogen Donor Count 2 Chemaxon
Polar Surface Area 69.73 Å2 Chemaxon
Rotatable Bond Count 7 Chemaxon
Refractivity 93.03 m3·mol-1 Chemaxon
Polarizability 35.89 Å3 Chemaxon
Number of Rings 3 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule No Chemaxon
MDDR-like Rule Yes Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

Drug created at June 16, 2014 18:29 / Updated at February 21, 2021 18:52