Calcium Phosphate

Identification

Summary

Calcium Phosphateis a compound used in supplements and antacids.

Generic Name

Calcium Phosphate

DrugBank Accession Number

DB11348

Background

Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes^Label3.

Type

Small Molecule

Groups

Approved

Structure

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MOL SDF PDB SMILES InChI

Similar Structures

Structure for Calcium Phosphate (DB11348)

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Weight

Average: 310.177
Monoisotopic: 309.794613465

Chemical Formula

Ca₃O₈P₂

Synonyms

• calcio fosfato
• Calcium phosphates
• Phosphoric acid, calcium salt

External IDs

• E-341(III)
• FEMA NO. 3081
• INS NO.341(III)
• INS-341(III)

Pharmacology

Indication

For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste^Label3.

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Associated Conditions

• Calcium Deficiency
• Calcium and Vitamin D Deficiencies
• Phosphate Deficiency

Associated Therapies

• Dental Care

Contraindications & Blackbox Warnings

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Pharmacodynamics

Calcium phosphate reacts with acid in the stomach to raise the pH³. In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth¹. As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.

Mechanism of action

The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH)². Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

Target	Actions	Organism
AExtracellular calcium-sensing receptor	agonist	Humans
NCalreticulin	ligand	Humans
UCalcium and integrin-binding protein 1	ligand	Humans
UProgrammed cell death protein 6	agonist	Humans
USorcin	ligand	Humans
UCalcineurin B homologous protein 1	agonist	Humans
NSPARC	ligand	Humans
NCalnexin	ligand	Humans
NFibrillin-2	ligand	Humans
NProtein S100-B	ligand	Humans
NCalsequestrin-2	ligand	Humans
NRegucalcin	ligand	Humans
NPeflin	ligand	Humans
UProtein S100-A6	ligand	Humans
NTranslationally-controlled tumor protein	ligand	Humans
UCalcium and integrin-binding family member 2	ligand	Humans
NProtein S100-A13	ligand	Humans
NCalsequestrin-1	ligand	Humans
UNucleobindin-1	ligand	Humans
UNucleobindin-2	ligand	Humans
UCalmodulin	agonist	Humans
UFibrillin-3	ligand	Humans
UGrancalcin	ligand	Humans
UCalcium-dependent secretion activator 1	agonist	Humans
UCalmodulin-2	agonist	Humans
UCalmodulin-3	agonist	Humans
UProtein S100-A16	ligand	Humans
UCalretinin	ligand	Humans
UCalcyphosin	ligand	Humans
UCalcium-dependent secretion activator 2	agonist	Humans
UCalreticulin-3	ligand	Humans
UNeurexin-1	agonist	Humans
UNeuronal calcium sensor 1	ligand	Humans

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">

Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Acebutolol	The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium Phosphate.
Acetyldigitoxin	Calcium Phosphate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alendronic acid	The serum concentration of Alendronic acid can be decreased when it is combined with Calcium Phosphate.
Alfacalcidol	The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium Phosphate.
Aluminum hydroxide	Aluminum hydroxide can cause a decrease in the absorption of Calcium Phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Atenolol	The therapeutic efficacy of Atenolol can be decreased when used in combination with Calcium Phosphate.
Bendroflumethiazide	Bendroflumethiazide may decrease the excretion rate of Calcium Phosphate which could result in a higher serum level.
Benzthiazide	Benzthiazide may decrease the excretion rate of Calcium Phosphate which could result in a higher serum level.
Betaxolol	The therapeutic efficacy of Betaxolol can be decreased when used in combination with Calcium Phosphate.
Bisoprolol	The therapeutic efficacy of Bisoprolol can be decreased when used in combination with Calcium Phosphate.

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Food Interactions

No interactions found.

Products

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Calcium phosphate, dibasic	L11K75P92J	7757-93-9	FUFJGUQYACFECW-UHFFFAOYSA-L
Calcium phosphate, tribasic	K4C08XP666	7758-87-4	QORWJWZARLRLPR-UHFFFAOYSA-H

Active Moieties

Name	Kind	UNII	CAS	InChI Key
Calcium	unknown	SY7Q814VUP	7440-70-2	OYPRJOBELJOOCE-UHFFFAOYSA-N
Phosphate ion	ionic	NK08V8K8HR	14265-44-2	NBIIXXVUZAFLBC-UHFFFAOYSA-K
Calcium cation	ionic	2M83C4R6ZB	14127-61-8	BHPQYMZQTOCNFJ-UHFFFAOYSA-N

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	图像
CAREDO Professional Cavities Treatment Toothpastes 100g	Paste, dentifrice	0.5 g/100g	Dental	Hong Kong Prosthodontics Medicine Limited	2018-07-03	2018-09-19
CAREDO Professional Cavities Treatment Toothpastes 100g	Paste, dentifrice	0.5 g/100g	Dental	Hong Kong Prosthodontics Medicine Limited	2018-07-03	Not applicable
CAREDO Repairing Dental Caries for Kids Toothpastes 50g	Paste, dentifrice	0.25 g/50g	Dental	Hong Kong Prosthodontics Medicine Limited	2018-07-03	Not applicable
CAREDO Repairing Dental Caries for Kids Toothpastes 50g	Paste, dentifrice	0.25 g/50g	Dental	Hong Kong Prosthodontics Medicine Limited	2018-07-03	2018-09-19
KUNDAL Sensitive Dental Care Tooth (Apple Chamomile Mint)	Paste	17 g/100g	Dental	THESKINFACTORY Co., Ltd.	2020-09-01	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	图像
28tak Gum Care Tooth	Calcium phosphate, dibasic(0.12 g/120g)+Alcloxa(0.12 g/120g)+Aminocaproic acid(0.12 g/120g)+Calcium carbonate(36.0 g/120g)	Paste, dentifrice	Oral	Elmeditec Co.,Ltd	2018-07-01	Not applicable
Central-vite 18 Essential	Calcium Phosphate(125 mg / tab)+Ascorbic acid(90 mg / tab)+Beta carotene(3000 unit / tab)+Biotin(45 mcg / tab)+Calcium(175 mg / tab)+Cholecalciferol(400 unit / tab)+Cupric oxide(2 mg / tab)+Cyanocobalamin(9 mcg / tab)+Ferrous fumarate(10 mg / tab)+Folic acid(0.4 mg / tab)+Magnesium(100 mg / tab)+Nicotinamide(40 mg / tab)+Calcium pantothenate(10 mg / tab)+Potassium Iodide(0.15 mg / tab)+Pyridoxine hydrochloride(3 mg / tab)+Riboflavin(3.2 mg / tab)+Thiamine mononitrate(2.25 mg / tab)+Vitamin A(2000 unit / tab)+alpha-Tocopherol acetate(25 unit / tab)	Tablet	Oral	Vita Health Products Inc	1998-04-24	2002-07-31
Century Complete	Calcium Phosphate(125 mg / tab)+Ascorbic acid(90 mg / tab)+Beta carotene(3000 unit / tab)+Biotin(45 mcg / tab)+Calcium(175 mg / tab)+Cupric oxide(2 mg / tab)+Cyanocobalamin(9 mcg / tab)+Ferrous fumarate(10 mg / tab)+Folic acid(.4 mg / tab)+Magnesium(100 mg / tab)+Nicotinamide(40 mg / tab)+Calcium pantothenate(10 mg / tab)+Potassium Iodide(.15 mg / tab)+Pyridoxine hydrochloride(3 mg / tab)+Riboflavin(3.2 mg / tab)+Thiamine mononitrate(2.25 mg / tab)+Vitamin A(2000 unit / tab)+Vitamin D(400 unit / tab)+alpha-Tocopherol acetate(25 unit / tab)	Tablet	Oral	Vita Health Products Inc	1998-03-17	2002-07-31
Children's Chewable Multivitamin and Multimineral	Calcium Phosphate(162 mg)+ Calcium Phosphate(125 mg)+Ascorbic acid(60 mg)+Beta carotene(250 unit)+Biotin(20 mcg)+Cupric oxide(2 mg)+Cyanocobalamin(5 mcg)+Ferrous fumarate(4 mg)+Folic acid(0.3 mg)+Nicotinamide(15 mg)+Calcium pantothenate(5 mg)+Potassium Iodide(0.15 mg)+Pyridoxine hydrochloride(1.7 mg)+Riboflavin(1.4 mg)+Thiamine mononitrate(1.2 mg)+Vitamin A acetate(2750 unit)+Vitamin D(400 unit)+Vitamin E(15 unit)	Tablet	Oral	Jamieson Laboratories Ltd	2006-09-20	2009-07-29
Children's Chewable Multivitamin and Multimineral	Calcium Phosphate(162 mg)+ Calcium Phosphate(125 mg)+Ascorbic acid(60 mg)+Beta carotene(250 unit)+Biotin(20 mcg)+Cupric oxide(2 mg)+Cyanocobalamin(5 mcg)+Ferrous fumarate(4 mg)+Folic acid(0.3 mg)+Nicotinamide(15 mg)+Calcium pantothenate(5 mg)+Potassium Iodide(0.15 mg)+Pyridoxine hydrochloride(1.7 mg)+Riboflavin(1.4 mg)+Thiamine mononitrate(1.2 mg)+Vitamin A acetate(2750 unit)+Vitamin D(400 unit)+Vitamin E(15 unit)	Tablet	Oral	Jamieson Laboratories Ltd	2006-09-20	2009-07-29
Children's Chewable Multivitamin Complete With Minerals	Calcium Phosphate(125 mg)+Ascorbic acid(75 mg)+Biotin(30 mcg)+Calcium(162 mg)+Cholecalciferol(400 unit)+Cupric oxide(1 mg)+Cyanocobalamin(4 mcg)+Ferrous fumarate(5 mg)+Folic acid(0.1 mg)+Nicotinamide(20 mg)+Calcium pantothenate(10 mg)+Potassium Iodide(0.15 mg)+Pyridoxine hydrochloride(2 mg)+Riboflavin(1.8 mg)+Thiamine mononitrate(1.6 mg)+Vitamin A(5000 unit)+alpha-Tocopherol acetate(10 unit)	Tablet	Oral	Wn Pharmaceuticals Ltd.	2002-05-31	2002-12-12
Clean Breath Tooth	Calcium phosphate, dibasic(0.07 g/100g)+Alcloxa(0.06 g/100g)+Aminocaproic acid(0.06 g/100g)+Calcium carbonate(36 g/100g)	Paste, dentifrice	Dental	K.Boeun Pharmaceutical Co.,Ltd.	2021-01-01	Not applicable
Clean Breath Tooth	Calcium phosphate, dibasic(0.07 g/100g)+Alcloxa(0.06 g/100g)+Aminocaproic acid(0.06 g/100g)+Calcium carbonate(36 g/100g)	Paste, dentifrice	Dental	K.Boeun Pharmaceutical Co.,Ltd.	2021-11-30	Not applicable
Clean Breath Tooth	Calcium phosphate, dibasic(0.07 g/100g)+Alcloxa(0.06 g/100g)+Aminocaproic acid(0.06 g/100g)+Calcium carbonate(36 g/100g)	Paste, dentifrice	Dental	K.Boeun Pharmaceutical Co.,Ltd.	2021-05-01	Not applicable
Complete Multivitamins and Minerals for Children	Calcium Phosphate(160 mg / tab)+ Calcium Phosphate(125 mg / tab)+Biotin(30 mcg / tab)+Cholecalciferol(400 unit / tab)+Cupric oxide(1 mg / tab)+Cyanocobalamin(3 mcg / tab)+Ferrous fumarate(4 mg / tab)+Folic acid(0.1 mg / tab)+Nicotinamide(15 mg / tab)+Calcium pantothenate(10 mg / tab)+Pyridoxine hydrochloride(1 mg / tab)+Riboflavin(1.5 mg / tab)+Sodium ascorbate(50 mg / tab)+Thiamine mononitrate(1.5 mg / tab)+Vitamin A palmitate(5000 unit / tab)+alpha-Tocopherol acetate(10 unit / tab)	Tablet	Oral	Quest Vitamins A Div Of Purity Life Health Products	2001-01-31	2004-06-29

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	图像
28tak Gum Care Tooth	Calcium phosphate, dibasic(0.12 g/120g)+Alcloxa(0.12 g/120g)+Aminocaproic acid(0.12 g/120g)+Calcium carbonate(36.0 g/120g)	Paste, dentifrice	Oral	Elmeditec Co.,Ltd	2018-07-01	Not applicable
CAREDO Professional Cavities Treatment Toothpastes 100g	Calcium phosphate, tribasic(0.5 g/100g)	Paste, dentifrice	Dental	Hong Kong Prosthodontics Medicine Limited	2018-07-03	2018-09-19
CAREDO Professional Cavities Treatment Toothpastes 100g	Calcium Phosphate(0.5 g/100g)	Paste, dentifrice	Dental	Hong Kong Prosthodontics Medicine Limited	2018-07-03	Not applicable
CAREDO Repairing Dental Caries for Kids Toothpastes 50g	Calcium Phosphate(0.25 g/50g)	Paste, dentifrice	Dental	Hong Kong Prosthodontics Medicine Limited	2018-07-03	Not applicable
CAREDO Repairing Dental Caries for Kids Toothpastes 50g	Calcium phosphate, tribasic(0.25 g/50g)	Paste, dentifrice	Dental	Hong Kong Prosthodontics Medicine Limited	2018-07-03	2018-09-19
Clean Breath Tooth	Calcium phosphate, dibasic(0.07 g/100g)+Alcloxa(0.06 g/100g)+Aminocaproic acid(0.06 g/100g)+Calcium carbonate(36 g/100g)	Paste, dentifrice	Dental	K.Boeun Pharmaceutical Co.,Ltd.	2021-11-30	Not applicable
Clean Breath Tooth	Calcium phosphate, dibasic(0.07 g/100g)+Alcloxa(0.06 g/100g)+Aminocaproic acid(0.06 g/100g)+Calcium carbonate(36 g/100g)	Paste, dentifrice	Dental	K.Boeun Pharmaceutical Co.,Ltd.	2021-01-01	Not applicable
Clean Breath Tooth	Calcium phosphate, dibasic(0.07 g/100g)+Alcloxa(0.06 g/100g)+Aminocaproic acid(0.06 g/100g)+Calcium carbonate(36 g/100g)	Paste, dentifrice	Dental	K.Boeun Pharmaceutical Co.,Ltd.	2021-05-01	Not applicable
DIO Enamel Coating Pen Pro Tooth	Calcium phosphate, tribasic(20 g/120g)+alpha-Tocopherol acetate(0.2 g/120g)	Paste, dentifrice	Dental	Dio	2016-05-01	2016-10-01
DIO Enamel Coating Pen Pro Tooth	Calcium phosphate, tribasic(20 g/100g)+Silicon dioxide(6 g/100g)+alpha-Tocopherol acetate(0.2 g/100g)	Paste, dentifrice	Dental	Dio	2016-05-01	Not applicable

Categories

ATC Codes

A12AA01 — Calcium phosphate

• A12AA — Calcium
• A12A — CALCIUM
• A12 — MINERAL SUPPLEMENTS
• A -消化道和新陈代谢

A11GB01 — Ascorbic acid (vit c) and calcium

• A11GB — Ascorbic acid (vitamin C), combinations
• A11G — ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
• A11 — VITAMINS
• A -消化道和新陈代谢

Drug Categories

• Acids
• Acids, Noncarboxylic
• Alimentary Tract and Metabolism
• Biocompatible Materials
• Calcium Compounds
• Calcium Salts
• Ceramics
• Compounds used in a research, industrial, or household setting
• Mineral Supplements
• Phosphate salts
• Phosphoric Acids
• Phosphorus Acids
• Phosphorus Compounds

Chemical TaxonomyProvided byClassyfire

Description

This compound belongs to the class of inorganic compounds known as alkaline earth metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal.

Kingdom

Inorganic compounds

Super Class

Mixed metal/non-metal compounds

Class

Alkaline earth metal oxoanionic compounds

Sub Class

Alkaline earth metal phosphates

Direct Parent

Alkaline earth metal phosphates

Alternative Parents

Inorganic oxides/Inorganic calcium salts

Substituents

Alkaline earth metal phosphate/Inorganic calcium salt/Inorganic oxide/Inorganic salt

Molecular Framework

Not Available

External Descriptors

calcium phosphate (CHEBI:9679)

Affected organisms

• Humans and other mammals

Chemical Identifiers

UNII

97Z1WI3NDX

CAS number

10103-46-5

InChI Key

QORWJWZARLRLPR-UHFFFAOYSA-H

InChI

InChI=1S/3Ca.2H3O4P/c;;;2*1-5(2,3)4/h;;;2*(H3,1,2,3,4)/q3*+2;;/p-6

IUPAC Name

tricalcium diphosphate

SMILES

[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

References

General References

1. 雷诺兹EC:钙磷酸盐remineralization systems: scientific evidence? Aust Dent J. 2008 Sep;53(3):268-73. doi: 10.1111/j.1834-7819.2008.00061.x. [Article]
2. 巴雷特柯、酒吧间招待员SM Boitano年代,布鲁克斯霍奇金淋巴瘤(2012). Ganong's Review of Medical Physiology (24th ed.). McGraw Hill. [ISBN:978-0-07-17803-2]
3. HSDB: Calcium Phosphate [Link]

External Links

KEGG Compound

C08136

PubChem Compound

24456

PubChem Substance

347827972

ChemSpider

22864

RxNav

1919

ChEBI

9679

ChEMBL

CHEMBL2106566

Wikipedia

Calcium_phosphate

FDA label

Download (382 KB)

MSDS

Download (182 KB)

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Completed	Treatment	Partial Edentulism	1
4	Not Yet Recruiting	Prevention	Orthodontic Appliance Complication/Tooth Demineralization	1
4	Recruiting	Treatment	Furcation Defects/Periodontal Disease	2
4	Recruiting	Treatment	Postoperative pain	1
4	Recruiting	Treatment	Vertigo	1
4	Unknown Status	Prevention	Oral Mucositis	1
3	Completed	Supportive Care	Childhood Acute Lymphoblastic Leukemia in Remission/Childhood Acute Myeloid Leukemia in Remission/Childhood Chronic Myelogenous Leukemia/Childhood Myelodysplastic Syndromes/Chronic Eosinophilic Leukemia (CEL)/Chronic Myelomonocytic Leukemia (CMML)/De Novo Myelodysplastic Syndromes/Disseminated Neuroblastoma/Juvenile Myelomonocytic Leukaemias (JMML)/Leukemia, Neutrophilic, Chronic/Mucositis/Myelodysplastic Syndromes, Previously Treated/Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable/Previously Treated Childhood Rhabdomyosarcoma/Recurrent Childhood Acute Lymphoblastic Leukemia/Recurrent Childhood Acute Myeloid Leukemia/Recurrent Childhood Large Cell Lymphoma/Recurrent Childhood Lymphoblastic Lymphoma/Recurrent Childhood Rhabdomyosarcoma/复发性童年小Noncleaved细胞淋巴瘤/Recurrent Malignant Testicular Germ Cell Tumor/Recurrent Wilms Tumor and Other Childhood Kidney Tumors/Recurrent/Refractory Childhood Hodgkin Lymphoma/Relapsing Chronic Myelogenous Leukemia/Secondary Acute Myeloid Leukemia (Secondary AML, sAML)/Secondary Myelodysplastic Syndromes/Unspecified Childhood Solid Tumor, Protocol Specific	1
3	Terminated	Prevention	Oral Mucositis	1
2	Active Not Recruiting	Prevention	Dental Decay/Tooth Demineralization/White Spot Lesions	1
2	Completed	Prevention	White Spot Lesions	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Paste, dentifrice	Oral
Powder	Oral
Tablet, coated	Oral	600 mg
Tablet, coated	Oral
Powder, for suspension	Oral
Paste, dentifrice	Dental	0.5 g/100g
Paste, dentifrice	Dental	0.25 g/50g
Tablet, film coated
Paste, dentifrice	Dental
Paste	Topical
Tablet, film coated	Oral	20 mg
Paste	Dental	17 g/100g
Paste, dentifrice	Topical
Liquid	Oral
Paste	Dental
Tablet	Oral
Capsule, liquid filled	Oral
Capsule, gelatin coated	Oral
Capsule	Oral
Tablet

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	>450	MSDS
water solubility	7.7g/L	MSDS

Predicted Properties

Property	Value	Source
Water Solubility	48.8 mg/mL	ALOGPS
logP	0.41	ALOGPS
logP	-1	ChemAxon
logS	-0.8	ALOGPS
pKa (Strongest Acidic)	1.8	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	86.25 Å2	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	11.29 m3·mol-1	ChemAxon
Polarizability	4.93 Å3	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Targets

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Details 1.Extracellular calcium-sensing receptor

Kind

Protein

Organism

Humans

Pharmacological action

Yes

Actions

Agonist

General Function

Phosphatidylinositol phospholipase c activity

Specific Function

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Gene Name

CASR

Uniprot ID

P41180

Uniprot Name

Extracellular calcium-sensing receptor

Molecular Weight

120672.385 Da

Details 2.Calreticulin

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Zinc ion binding

Specific Function

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently wit...

Gene Name

CALR

Uniprot ID

P27797

Uniprot Name

Calreticulin

Molecular Weight

48141.2 Da

References

1. UniProt: Calreticulin [Link]

Details 3.Calcium and integrin-binding protein 1

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

钙结合蛋白,在r中扮演了重要的角色egulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

Specific Function

Calcium ion binding

Gene Name

CIB1

Uniprot ID

Q99828

Uniprot Name

Calcium and integrin-binding protein 1

Molecular Weight

21703.07 Da

References

1. UniProt: Calcium and integrin-binding protein 1 [Link]

Details 4.Programmed cell death protein 6

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

Protein dimerization activity

Specific Function

Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent a...

Gene Name

PDCD6

Uniprot ID

O75340

Uniprot Name

Programmed cell death protein 6

Molecular Weight

21868.32 Da

References

1. Uniprot: Programmed cell death protein 6 [Link]

Details 5.Sorcin

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Specific Function

Calcium channel regulator activity

Gene Name

SRI

Uniprot ID

P30626

Uniprot Name

Sorcin

Molecular Weight

21676.245 Da

References

1. UniProt: Sorcin [Link]

Details 6.Calcineurin B homologous protein 1

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

钙结合蛋白参与不同的processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

Specific Function

Calcium ion binding

Gene Name

CHP1

Uniprot ID

Q99653

Uniprot Name

Calcineurin B homologous protein 1

Molecular Weight

22455.96 Da

References

1. UniProt: Calcineurin B homologous protein 1 [Link]

Details 7.SPARC

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Extracellular matrix binding

Specific Function

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membran...

Gene Name

SPARC

Uniprot ID

P09486

Uniprot Name

SPARC

Molecular Weight

34631.88 Da

References

1. UniProt: SPARC [Link]

Details 8.Calnexin

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Poly(a) rna binding

Specific Function

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembl...

Gene Name

CANX

Uniprot ID

P27824

Uniprot Name

Calnexin

Molecular Weight

67567.695 Da

References

1. UniProt: Calnexin [Link]

Details 9.Fibrillin-2

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

Specific Function

Calcium ion binding

Gene Name

FBN2

Uniprot ID

P35556

Uniprot Name

Fibrillin-2

Molecular Weight

314772.155 Da

References

1. UniProt: Fibrillin-2 [Link]

Details 10.Protein S100-B

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Zinc ion binding

Specific Function

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the b...

Gene Name

S100B

Uniprot ID

P04271

Uniprot Name

Protein S100-B

Molecular Weight

10712.985 Da

References

1. UniProt: Protein S100-B [Link]

Details 11.Calsequestrin-2

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.

Specific Function

Calcium ion binding

Gene Name

CASQ2

Uniprot ID

O14958

Uniprot Name

Calsequestrin-2

Molecular Weight

46435.28 Da

References

1. UniProt: Calsequestrin-2 [Link]

Details 12.Regucalcin

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Zinc ion binding

Specific Function

Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calci...

Gene Name

RGN

Uniprot ID

Q15493

Uniprot Name

Regucalcin

Molecular Weight

33252.53 Da

References

1. UniProt: Regucalcin [Link]

Details 13.Peflin

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Its role in the heterodimer formed with PDCD6 is however unclear: some evidences show that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium (PubMed:27716508). Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (PubMed:11278427). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity).

Specific Function

Binding, bridging

Gene Name

PEF1

Uniprot ID

Q9UBV8

Uniprot Name

Peflin

Molecular Weight

30380.755 Da

References

1. UniProt: Peflin [Link]

Details 14.Protein S100-A6

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Zinc ion binding

Specific Function

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a rol...

Gene Name

S100A6

Uniprot ID

P06703

Uniprot Name

Protein S100-A6

Molecular Weight

10179.635 Da

References

1. UniProt: Protein S100-A6 [Link]

Details 15.Translationally-controlled tumor protein

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Involved in calcium binding and microtubule stabilization.

Specific Function

Calcium ion binding

Gene Name

TPT1

Uniprot ID

P13693

Uniprot Name

Translationally-controlled tumor protein

Molecular Weight

19595.205 Da

References

1. UniProt: Translationally-controlled tumor protein [Link]

Details 16.Calcium and integrin-binding family member 2

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331, PubMed:26173970, PubMed:26426422). May be involved in the mechanotransduction process (By similarity).

Specific Function

Calcium ion binding

Gene Name

CIB2

Uniprot ID

O75838

Uniprot Name

Calcium and integrin-binding family member 2

Molecular Weight

21643.38 Da

References

1. UniProt: Calcium and integrin-binding family member 2 [Link]

Details 17.Protein S100-A13

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Zinc ion binding

Specific Function

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion doe...

Gene Name

S100A13

Uniprot ID

Q99584

Uniprot Name

Protein S100-A13

Molecular Weight

11471.095 Da

References

1. UniProt: Protein S100-A13 [Link]

Details 18.Calsequestrin-1

Kind

Protein

Organism

Humans

Pharmacological action

No

Actions

Ligand

General Function

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.

Specific Function

Calcium ion binding

Gene Name

CASQ1

Uniprot ID

P31415

Uniprot Name

Calsequestrin-1

Molecular Weight

45159.635 Da

References

1. UniProt: Calsequestrin-1 [Link]

Details 19.Nucleobindin-1

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity).

Specific Function

Calcium ion binding

Gene Name

NUCB1

Uniprot ID

Q02818

Uniprot Name

Nucleobindin-1

Molecular Weight

53878.96 Da

References

1. UniProt: Nucleobindin-1 [Link]

Details 20.Nucleobindin-2

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Calcium-binding protein. May have a role in calcium homeostasis.

Specific Function

Calcium ion binding

Gene Name

NUCB2

Uniprot ID

P80303

Uniprot Name

Nucleobindin-2

Molecular Weight

50195.385 Da

References

1. UniProt: Nucleobindin-2 [Link]

Details 21.Calmodulin

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

Titin binding

Specific Function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number...

Gene Name

CALM1

Uniprot ID

P0DP23

Uniprot Name

Calmodulin

Molecular Weight

16837.47 Da

References

1. UniProt: Calmodulin-1 [Link]

Details 22.Fibrillin-3

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Fibrillin-3: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support.

Specific Function

Calcium ion binding

Gene Name

FBN3

Uniprot ID

Q75N90

Uniprot Name

Fibrillin-3

Molecular Weight

300352.86 Da

References

1. UniProt: Fibrillin-3 [Link]

Details 23.Grancalcin

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.

Specific Function

Calcium ion binding

Gene Name

GCA

Uniprot ID

P28676

Uniprot Name

Grancalcin

Molecular Weight

24009.85 Da

References

1. UniProt: Grancalcin [Link]

Details 24.Calcium-dependent secretion activator 1

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

钙结合蛋白参与胞外分泌vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).

Specific Function

Lipid binding

Gene Name

CADPS

Uniprot ID

Q9ULU8

Uniprot Name

Calcium-dependent secretion activator 1

Molecular Weight

152785.36 Da

References

1. UniProt: Calcium-dependent secretion activator 1 [Link]

Details 25.Calmodulin-2

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).

Specific Function

Calcium channel inhibitor activity

Gene Name

CALM2

Uniprot ID

P0DP24

Uniprot Name

Calmodulin-2

Molecular Weight

16837.47 Da

References

1. UniProt: Calmodulin-2 [Link]

Details 26.Calmodulin-3

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

Specific Function

Calcium ion binding

Gene Name

CALM3

Uniprot ID

P0DP25

Uniprot Name

Calmodulin-3

Molecular Weight

16837.47 Da

References

1. UniProt: Calmodulin-3 [Link]

Details 27.Protein S100-A16

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Calcium-binding protein. Binds one calcium ion per monomer.

Specific Function

Calcium ion binding

Gene Name

S100A16

Uniprot ID

Q96FQ6

Uniprot Name

Protein S100-A16

Molecular Weight

11801.3 Da

References

1. UniProt: Protein S100-A16 [Link]

Details 28.Calretinin

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Specific Function

Calcium ion binding

Gene Name

CALB2

Uniprot ID

P22676

Uniprot Name

Calretinin

Molecular Weight

31539.62 Da

References

1. UniProt: Calretinin [Link]

Details 29.Calcyphosin

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Calcium-binding protein. May play a role in cellular signaling events (Potential).

Specific Function

Calcium ion binding

Gene Name

CAPS

Uniprot ID

Q13938

Uniprot Name

Calcyphosin

Molecular Weight

20967.15 Da

References

1. UniProt: Calcyphosin [Link]

Details 30.Calcium-dependent secretion activator 2

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

钙结合蛋白参与胞外分泌vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).

Specific Function

Lipid binding

Gene Name

CADPS2

Uniprot ID

Q86UW7

Uniprot Name

Calcium-dependent secretion activator 2

Molecular Weight

147733.365 Da

References

1. UniProt: Calcium-dependent secretion activator 2 [Link]

Details 31.Calreticulin-3

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.

Specific Function

Calcium ion binding

Gene Name

CALR3

Uniprot ID

Q96L12

Uniprot Name

Calreticulin-3

Molecular Weight

44995.345 Da

References

1. UniProt: Calreticulin-3 [Link]

Details 32.Neurexin-1

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

Receptor activity

Specific Function

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-term...

Gene Name

NRXN1

Uniprot ID

Q9ULB1

Uniprot Name

Neurexin-1

Molecular Weight

161881.53 Da

References

1. UniProt: Neurexin-1 [Link]

Details 33.Neuronal calcium sensor 1

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Ligand

General Function

Voltage-gated calcium channel activity

Specific Function

Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (...

Gene Name

NCS1

Uniprot ID

P62166

Uniprot Name

Neuronal calcium sensor 1

Molecular Weight

21878.565 Da

References

1. UniProt: Neuronal calcium sensor 1 [Link]

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Drug created at December 03, 2015 16:52 / Updated at June 12, 2020 16:53