NAV

Carbarsone

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Carbarsone
DrugBank Accession Number
DB11382
Background

Carbarsone is a compound used as an antiprotozoal drug for the treatment of histomoniasis (or blackhead disease) in addition to other infectious diseases in chicken and turkeys. It belongs to theorganoarsenicgroup of chemical compounds and has antiamebic properties. It is also used as a food additive with the goal of increasing weight gain and controlling the occurrence of blackhead disease in chicken and turkeys.

Type
Small Molecule
Groups
Vet approved
Structure
MOL SDF PDB SMILES InChI
Similar Structures
Weight
Average: 260.079
Monoisotopic: 259.977828203
Chemical Formula
C7H9AsN2O4
Synonyms
  • Carbarson
  • Carbarsone
  • Carbarsonum
  • Pentarsone
  • Phenarsone

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as n-phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a urea group.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
N-phenylureas
Direct Parent
N-phenylureas
Alternative Parents
Pentaorganoarsanes/Ureas/Oxygen-containing organoarsenic compounds/Organic metalloid salts/Organopnictogen compounds/Organonitrogen compounds/Organic oxides/Hydrocarbon derivatives/Carbonyl compounds
Substituents
Aromatic homomonocyclic compound/Carbonic acid derivative/Carbonyl group/Hydrocarbon derivative/N-phenylurea/Organic metalloid salt/Organic nitrogen compound/Organic oxide/Organic oxygen compound/Organic salt
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
8PK70TXE1T
CAS number
121-59-5
InChI Key
WWXBHTZSYYGCSG-UHFFFAOYSA-N
InChI
InChI=1S/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14)
IUPAC Name
[4-(carbamoylamino)phenyl]arsonic acid
SMILES
NC(=O)NC1=CC=C(C=C1)[As](O)(O)=O

References

一般References
  1. Authors unspecified: CARBARSONE. Bull Am Pharm Assoc. 1946 Mar-Apr;14:76. [Article]
  2. GREEN MW: Acetarsone, carbarsone and iodochlorohydroxyquinoline. J Am Pharm Assoc Am Pharm Assoc (Baltim). 1946 Apr;7:150-2. [Article]
  3. Authors unspecified: The determination of carbarsone in animal feeds. Analyst. 1971 Nov;96(148):817-23. [Article]
  4. ALBORNOZ PLATA A: [Erythromycin-carbarsone in the treatment of amebiasis]. Rev Fac Med Univ Nac Colomb. 1959 Oct-Dec;27:235-44. [Article]
  5. SHERSHIN PH, DAVIS VT: Toxicity of carbarsone as an anti-amebic. J Med Soc N J. 1957 Jul;54(7):322-3. [Article]
  6. GREEN MW: The use of acetarsone, carbarsone, and iodochlorohydroxyquinoline. Bull Am Pharm Assoc. 1946 Mar-Apr;14:75-80. [Article]
  7. NELSON RS: Hepatitis due to carbarsone; report of two cases. J Am Med Assoc. 1956 Mar 3;160(9):764-6. [Article]
  8. LITTLE RP: Carbarsone in the treatment of pemphigus; a preliminary report. Arch Derm Syphilol. 1945 Nov-Dec;52:397. [Article]
  9. CONN HC, FELDMAN PW: Treatment of amebiasis. Results with diodoquin and carbarsone. Postgrad Med. 1951 Feb;9(2):137-40. [Article]
  10. RADKE RA: Treatment of amebiasis with atabrine combined with carbarsone. Ann Intern Med. 1951 Jun;34(6):1432-44. [Article]
ChemSpider
8167
RxNav
20206
ChEBI
94806
ChEMBL
CHEMBL1331366
Wikipedia
Carbarsone

Clinical Trials

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Phase Status Purpose Conditions Count

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 3.08 mg/mL ALOGPS
logP -0.39 ALOGPS
logP -0.017 Chemaxon
logS -1.9 ALOGPS
pKa (Strongest Acidic) 3.5 Chemaxon
pKa (Strongest Basic) -3.7 Chemaxon
Physiological Charge -1 Chemaxon
Hydrogen Acceptor Count 4 Chemaxon
Hydrogen Donor Count 4 Chemaxon
Polar Surface Area 112.65 Å2 Chemaxon
Rotatable Bond Count 2 Chemaxon
Refractivity 45.59 m3·mol-1 Chemaxon
Polarizability 19.99 Å3 Chemaxon
Number of Rings 1 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule No Chemaxon
MDDR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

Drug created at February 25, 2016 18:17 / Updated at February 21, 2021 18:53