This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
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Nordazepamis a benzodiazepine indicated in the treatment of insomnia.
- Generic Name
- Nordazepam
- DrugBank Accession Number
- DB14028
- Background
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An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
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Structure for Nordazepam (DB14028)
- Weight
-
Average: 270.714
Monoisotopic: 270.055990691 - Chemical Formula
- C15H11ClN2O
- Synonyms
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- Desmethyldiazepam
- N-desmethyldiazepam
- Nordazepam
- Nordazepam CIV
- Nordazepamum
- Nordiazepam
- External IDs
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- A 101
- A101
- RO 5-2180
Pharmacology
- Indication
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不可用
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with evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets. - Associated Conditions
- Contraindications & Blackbox Warnings
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information oncontraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support. - Pharmacodynamics
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不可用
- Mechanism of action
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Target Actions Organism AGABA(A) Receptor positive allosteric modulatorHumans AGABA(A) Receptor Benzodiazepine Binding Site ligandHumans - Absorption
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不可用
- Volume of distribution
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不可用
- Protein binding
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不可用
- Metabolism
- 不可用
- Route of elimination
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不可用
- Half-life
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不可用
- Clearance
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不可用
- Adverse Effects
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Improve decision support & research outcomesWith structured adverse effects data, including:blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data. - Toxicity
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不可用
- Pathways
- 不可用
- Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- 不可用
Interactions
- Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine 不良的风险或严重性effects can be increased when 1,2-Benzodiazepine is combined with Nordazepam. Acetazolamide 不良的风险或严重性effects can be increased when Acetazolamide is combined with Nordazepam. Acetophenazine 不良的风险或严重性effects can be increased when Acetophenazine is combined with Nordazepam. Aclidinium Nordazepam may increase the central nervous system depressant (CNS depressant) activities of Aclidinium. Agomelatine 不良的风险或严重性effects can be increased when Agomelatine is combined with Nordazepam. Alfentanil 不良的风险或严重性effects can be increased when Alfentanil is combined with Nordazepam. Alimemazine 不良的风险或严重性effects can be increased when Alimemazine is combined with Nordazepam. Almotriptan 不良的风险或严重性effects can be increased when Almotriptan is combined with Nordazepam. Alosetron 不良的风险或严重性effects can be increased when Alosetron is combined with Nordazepam. Alprazolam 不良的风险或严重性effects can be increased when Alprazolam is combined with Nordazepam. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- 不可用
Products
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Drug product information from 10+ global regionsOur datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions. - International/Other Brands
- Calmday/Lomax/Madar/Sopax/Stilny/Vegesan
Categories
- ATC Codes
- N05BA16 — Nordazepam
- Drug Categories
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- Amino Acids
- Amino Acids, Aromatic
- Amino Acids, Cyclic
- Amino Acids, Peptides, and Proteins
- Anti-Anxiety Agents
- Benzazepines
- Benzodiazepines and benzodiazepine derivatives
- Benzodiazepinones
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Modulators
- Heterocyclic Compounds, Fused-Ring
- Nervous System
- Neurotransmitter Agents
- Psycholeptics
- Psychotropic Drugs
- Tranquilizing Agents
- Chemical TaxonomyProvided byClassyfire
-
- Description
- This compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzodiazepines
- Sub Class
- 1,4-benzodiazepines
- Direct Parent
- 1,4-benzodiazepines
- Alternative Parents
- Benzene and substituted derivatives/Aryl chlorides/Cyclic carboximidic acids/Ketimines/Propargyl-type 1,3-dipolar organic compounds/Azacyclic compounds/Organopnictogen compounds/Organooxygen compounds/Organochlorides/Hydrocarbon derivatives
- Substituents
- 1,4-benzodiazepine/Aromatic heteropolycyclic compound/Aryl chloride/Aryl halide/Azacycle/Benzenoid/Cyclic carboximidic acid/Hydrocarbon derivative/Imine/Ketimine
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- organochlorine compound, 1,4-benzodiazepinone (CHEBI:111762)
- Affected organisms
- 不可用
Chemical Identifiers
- UNII
- 67220MCM01
- CAS number
- 1088-11-5
- InChI Key
- AKPLHCDWDRPJGD-UHFFFAOYSA-N
- InChI
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InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
- IUPAC Name
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7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
- SMILES
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ClC1=CC=C2NC(=O)CN=C(C3=CC=CC=C3)C2=C1
References
- General References
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- AIFA: Madar (Nordazepam) Oral Tablet [Link]
- External Links
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- Human Metabolome Database
- HMDB0060538
- KEGG Drug
- D08283
- KEGG Compound
- C07486
- ChemSpider
- 2890
- BindingDB
- 50027835
- 3155
- ChEBI
- 111762
- ChEMBL
- CHEMBL523
- ZINC
- ZINC000001249069
- Wikipedia
- Nordazepam
Clinical Trials
- Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
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Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
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不可用
- Packagers
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不可用
- Dosage Forms
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Form Route Strength Pill Tablet, coated Tablet Oral 15 mg - Prices
- 不可用
- Patents
- 不可用
Properties
- State
- Solid
- Experimental Properties
- 不可用
- Predicted Properties
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Property Value Source Water Solubility 0.0219 mg/mL ALOGPS logP 2.79 ALOGPS logP 3.21 ChemAxon logS -4.1 ALOGPS pKa (Strongest Acidic) 12.3 ChemAxon pKa (Strongest Basic) 2.85 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 41.46 Å2 ChemAxon Rotatable Bond Count 1 ChemAxon Refractivity 76.7 m3·mol-1 ChemAxon Polarizability 27.41 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- 不可用
Spectra
- Mass Spec (NIST)
- 不可用
- Spectra
Targets
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- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
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Yes
- Actions
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Positive allosteric modulator
- Curator comments
- The GABA(A) receptor is pentameric (i.e. comprising 5 subunit proteins) and therefore has a multitude of potential isoforms. The above target is a collection of all possible GABA(A) subunits that may participate in the formation of the pentameric receptor and is not meant to imply direct a drug-protein interaction for each individual subunit.
- General Function
- 抑制细胞外ligand-gated离子通道activity
- Specific Function
- Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...
Components:
References
- Sigel E, Steinmann ME: Structure, function, and modulation of GABA(A) receptors. J Biol Chem. 2012 Nov 23;287(48):40224-31. doi: 10.1074/jbc.R112.386664. Epub 2012 Oct 4. [Article]
- Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE: Structure of a human synaptic GABAA receptor. Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
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Yes
- Actions
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Ligand
- Curator comments
- Benzodiazepines modulate GABA(A) function by binding at the interface between alpha (α) and gamma (γ) subunits. Of the 6 α-subunits, only 4 (α-1, -2, -3, and -5) participate in the formation of this binding site. The above target is a collection of all α- and γ-subunits that are known to participate in the formation of the benzodiazepine binding site.
- General Function
- 抑制细胞外ligand-gated离子通道activity
- Specific Function
- Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...
Components:
References
- Sigel E, Steinmann ME: Structure, function, and modulation of GABA(A) receptors. J Biol Chem. 2012 Nov 23;287(48):40224-31. doi: 10.1074/jbc.R112.386664. Epub 2012 Oct 4. [Article]
- Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE: Structure of a human synaptic GABAA receptor. Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27. [Article]
Drug created at May 15, 2018 20:27 / Updated at May 14, 2021 01:06