NAV

Ketocaine

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Ketocaineis a medication indicated in the treatment of hemorrhoids, anal fissues, and perioperative and postoperative care of the rectum.

Generic Name
Ketocaine
DrugBank Accession Number
DB16020
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
 3D
Similar Structures
Weight
Average: 291.435
Monoisotopic: 291.219829178
Chemical Formula
C18H29NO2
Synonyms
  • Cetocaina
  • Ketocaine
  • Ketocainum
External IDs
  • 214-131-8

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
Ingredient UNII CAS InChI Key
Ketocaine hydrochloride LM1ZPQ7AX0 1092-47-3 KLTGHWCBYMXNQD-UHFFFAOYSA-N

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
WA1RT89G9X
化学文摘号
1092-46-2
InChI Key
UXAWFWFJXIANHZ-UHFFFAOYSA-N
InChI
InChI=1S/C18H29NO2/c1-6-9-17(20)16-10-7-8-11-18(16)21-13-12-19(14(2)3)15(4)5/h7-8,10-11,14-15H,6,9,12-13H2,1-5H3
IUPAC Name
1-(2-{2-[bis(propan-2-yl)amino]ethoxy}phenyl)butan-1-one
SMILES
CCCC(=O)C1=C(OCCN(C(C)C)C(C)C)C=CC=C1

References

一般引用
  1. AFIA: Proctolyn (Fluocinolone Acetonide, Ketocain) Rectal Cream and Suppository [Link]
ChemSpider
62170
ChEMBL
CHEMBL2107306
ZINC
ZINC000000000412
Wikipedia
Ketocaine

Clinical Trials

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Phase Status Purpose Conditions Count

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Form Route Strength
Cream Rectal
Suppository Rectal
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 0.101 mg/mL ALOGPS
logP 4.22 ALOGPS
logP 4.08 Chemaxon
logS -3.5 ALOGPS
pKa (Strongest Acidic) 16.86 Chemaxon
pKa (Strongest Basic) 9.69 Chemaxon
Physiological Charge 1 Chemaxon
Hydrogen Acceptor Count 3 Chemaxon
Hydrogen Donor Count 0 Chemaxon
Polar Surface Area 29.54 Å2 Chemaxon
Rotatable Bond Count 9 Chemaxon
Refractivity 88.51 m3·mol-1 Chemaxon
Polarizability 34.85 Å3 Chemaxon
Number of Rings 1 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule Yes Chemaxon
医学博士DR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at December 14, 2020 13:47 / Updated at May 05, 2021 20:32