Zollinger-Ellison Syndrome

Also known as:Zollinger Ellison syndrome/Gastrinoma/Syndrome Zollinger Ellison/Z-E syndrome/Hypergastrinemia

Drug Drug Name Drug Description
DB00501 Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
DB00736 Esomeprazole A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion.
DB00927 Famotidine A histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome.
DB00448 Lansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
DB00338 Omeprazole A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection.
DB00213 Pantoprazole A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid.
DB01129 Rabeprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
DB00863 Ranitidine A histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.
DB01390 Sodium bicarbonate A compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.
Drug Drug Name Target Type
DB00501 Cimetidine Histamine H2 receptor target
DB00501 Cimetidine Cytochrome P450 1A2 enzyme
DB00501 Cimetidine Cytochrome P450 2D6 enzyme
DB00501 Cimetidine Cytochrome P450 2C19 enzyme
DB00501 Cimetidine Cytochrome P450 3A4 enzyme
DB00501 Cimetidine Cytochrome P450 3A5 enzyme
DB00501 Cimetidine P-glycoprotein 1 transporter
DB00501 Cimetidine Solute carrier family 22 member 2 transporter
DB00501 Cimetidine 溶质载体家庭22个成员1 transporter
DB00501 Cimetidine Solute carrier family 22 member 3 transporter
DB00501 Cimetidine Solute carrier family 22 member 5 transporter
DB00501 Cimetidine Solute carrier family 22 member 6 transporter
DB00501 Cimetidine Solute carrier family 22 member 8 transporter
DB00501 Cimetidine Multidrug and toxin extrusion protein 1 transporter
DB00501 Cimetidine Solute carrier family 22 member 4 transporter
DB00501 Cimetidine 溶质载体家庭22个成员11 transporter
DB00501 Cimetidine Solute carrier family 22 member 7 transporter
DB00501 Cimetidine Cytochrome P450 11B1, mitochondrial enzyme
DB00501 Cimetidine Cytochrome P450 2C8 enzyme
DB00501 Cimetidine Cytochrome P450 2C9 enzyme
DB00501 Cimetidine Cytochrome P450 2E1 enzyme
DB00501 Cimetidine Dimethylaniline monooxygenase [N-oxide-forming] 3 enzyme
DB00501 Cimetidine Dimethylaniline monooxygenase [N-oxide-forming] 1 enzyme
DB00501 Cimetidine Bile salt export pump transporter
DB00501 Cimetidine Multidrug and toxin extrusion protein 2 transporter
DB00501 Cimetidine Serum albumin carrier
DB00736 Esomeprazole Potassium-transporting ATPase alpha chain 1 target
DB00736 Esomeprazole Cytochrome P450 2C19 enzyme
DB00736 Esomeprazole Cytochrome P450 3A4 enzyme
DB00736 Esomeprazole N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 target
DB00736 Esomeprazole P-glycoprotein 1 transporter
DB00736 Esomeprazole Solute carrier family 22 member 8 transporter
DB00927 Famotidine Histamine H2 receptor target
DB00927 Famotidine Solute carrier family 22 member 2 transporter
DB00927 Famotidine Solute carrier family 22 member 8 transporter
DB00927 Famotidine Multidrug and toxin extrusion protein 1 transporter
DB00927 Famotidine Cytochrome P450 1A2 enzyme
DB00927 Famotidine Solute carrier family 22 member 6 transporter
DB00448 Lansoprazole Potassium-transporting ATPase alpha chain 1 target
DB00448 Lansoprazole Cytochrome P450 2C19 enzyme
DB00448 Lansoprazole Cytochrome P450 2C9 enzyme
DB00448 Lansoprazole Cytochrome P450 3A4 enzyme
DB00448 Lansoprazole P-glycoprotein 1 transporter
DB00448 Lansoprazole ATP-binding cassette sub-family G member 2 transporter
DB00448 Lansoprazole Cytochrome P450 1A1 enzyme
DB00448 Lansoprazole Cytochrome P450 1B1 enzyme
DB00448 Lansoprazole Cytochrome P450 2C18 enzyme
DB00448 Lansoprazole Cytochrome P450 2C8 enzyme
DB00448 Lansoprazole Cytochrome P450 2D6 enzyme
DB00448 Lansoprazole Microtubule-associated protein tau target
DB00448 Lansoprazole Solute carrier family 22 member 8 transporter
DB00448 Lansoprazole 溶质载体家庭22个成员1 transporter
DB00448 Lansoprazole Solute carrier family 22 member 2 transporter
DB00448 Lansoprazole Solute carrier family 22 member 3 transporter
DB00338 Omeprazole Potassium-transporting ATPase alpha chain 1 target
DB00338 Omeprazole Cytochrome P450 2C19 enzyme
DB00338 Omeprazole Cytochrome P450 3A4 enzyme
DB00338 Omeprazole Cytochrome P450 2C9 enzyme
DB00338 Omeprazole Cytochrome P450 1A2 enzyme
DB00338 Omeprazole Canalicular multispecific organic anion transporter 2 transporter
DB00338 Omeprazole P-glycoprotein 1 transporter
DB00338 Omeprazole ATP-binding cassette sub-family G member 2 transporter
DB00338 Omeprazole Cytochrome P450 1A1 enzyme
DB00338 Omeprazole Cytochrome P450 1B1 enzyme
DB00338 Omeprazole Cytochrome P450 2C18 enzyme
DB00338 Omeprazole Cytochrome P450 2C8 enzyme
DB00338 Omeprazole Cytochrome P450 2D6 enzyme
DB00338 Omeprazole Aryl hydrocarbon receptor target
DB00213 Pantoprazole Potassium-transporting ATPase alpha chain 1 target
DB00213 Pantoprazole Cytochrome P450 2C19 enzyme
DB00213 Pantoprazole Cytochrome P450 3A4 enzyme
DB00213 Pantoprazole P-glycoprotein 1 transporter
DB00213 Pantoprazole ATP-binding cassette sub-family G member 2 transporter
DB00213 Pantoprazole Solute carrier family 22 member 8 transporter
DB00213 Pantoprazole N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 target
DB01129 Rabeprazole Potassium-transporting ATPase alpha chain 1 target
DB01129 Rabeprazole Cytochrome P450 3A4 enzyme
DB01129 Rabeprazole Cytochrome P450 2C19 enzyme
DB01129 Rabeprazole ATP-binding cassette sub-family G member 2 transporter
DB01129 Rabeprazole Cytochrome P450 1A1 enzyme
DB01129 Rabeprazole Cytochrome P450 1A2 enzyme
DB01129 Rabeprazole Cytochrome P450 2C9 enzyme
DB01129 Rabeprazole Cytochrome P450 2D6 enzyme
DB01129 Rabeprazole Cytochrome P450 2C8 enzyme
DB00863 Ranitidine Histamine H2 receptor target
DB00863 Ranitidine Cytochrome P450 1A2 enzyme
DB00863 Ranitidine Cytochrome P450 2D6 enzyme
DB00863 Ranitidine 溶质载体家庭22个成员1 transporter
DB00863 Ranitidine P-glycoprotein 1 transporter
DB00863 Ranitidine Solute carrier family 22 member 8 transporter
DB00863 Ranitidine Cytochrome P450 3A4 enzyme
DB00863 Ranitidine Acetylcholinesterase target
DB00863 Ranitidine Solute carrier family 22 member 2 transporter
DB00863 Ranitidine Acetylcholinesterase enzyme
DB01390 Sodium bicarbonate Electrogenic sodium bicarbonate cotransporter 1 transporter
DB01390 Sodium bicarbonate Sodium bicarbonate cotransporter 3 transporter
DB01390 Sodium bicarbonate 电中性的年代odium bicarbonate exchanger 1 transporter
DB01390 Sodium bicarbonate Electrogenic sodium bicarbonate cotransporter 4 transporter
DB01390 Sodium bicarbonate Hydrogen ions target
DB01390 Sodium bicarbonate Sodium-driven chloride bicarbonate exchanger transporter
Drug Drug Name Phase Status Count
DB01101 Capecitabine 1 Withdrawn 1
DB00853 Temozolomide 1 Withdrawn 1
DB07232 Veliparib 1 Withdrawn 1
DB00997 Doxorubicin 2 Completed 1
DB00544 Fluorouracil 2 Completed 1
DB12355 Netazepide 2 Terminated 1
DB00338 Omeprazole 2 Completed 1
DB00213 Pantoprazole 2 Completed 1
DB00428 Streptozocin 2 Completed 1
DB00736 Esomeprazole 3 Completed 1
DB00448 Lansoprazole 4 Completed 1