Heterozygous Familial Hypercholesterolemia (HeFH)
Also known as:Familial Hypercholesterolemia - Heterozygous/Heterozygous Familial Hypercholesterolaemia/Heterozygous Familial Hypercholesterolemia/Familial hypercholesterolemia - heterozygous (disorder)/Fredrickson's hyperlipoproteinemia, type IIa/Type IIa hyperlipoproteinemia/Hyperlipoproteinemia Type IIa/Fredrickson Type IIa hyperlipoproteinemia/Fredrickson type IIa hyperlipoproteinemia (disorder)/Familial hypercholesterolemia (disorder)/Type IIa hyperlipoproteinaemia/Fredrickson Type IIa hyperlipoproteinaemia/Fredrickson Type IIa hyperlipidemia/Fredrickson Type IIa hyperlipidaemia/Fredrickson Type IIa lipidemia/(Hypercholesterolaemia: [pure] or [familial]) or (Fredrickson type IIa lipidaemia) or (low density lipoproteinaemia)/Fredrickson Type IIa lipidaemia/Type IIa hyperlipidaemia/Type IIa hyperlipidemia
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB00945 | Acetylsalicylic acid | A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. |
| DB09302 | Alirocumab | A PCSK9 inhibitor used as an adjunct to manage heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease in patients who require additional lowering of LDL-cholesterol (LDL-C). |
| DB01076 | Atorvastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. |
| DB11936 | Bempedoic acid | A drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia. |
| DB00930 | Colesevelam | A bile acid sequestrant used to lower LDL-C in adults with hyperlipidemia and pediatric patients with heterozygous familial hypercholesterolemia, and to improve glycemic control in type 2 diabetes. |
| DB09303 | Evolocumab | A PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures. |
| DB01095 | Fluvastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. |
| DB14901 | Inclisiran | A PCSK9-targeting short interfering RNA (siRNA) that lowers plasma LDL-cholesterol levels. |
| DB00227 | Lovastatin | β-还原酶抑制剂用于降低LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. |
| DB08860 | Pitavastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. |
| DB00175 | Pravastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke. |
| DB01098 | Rosuvastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. |
| DB00641 | Simvastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. |
| Drug | Drug Name | Phase | Status | Count |
|---|---|---|---|---|
| DB11629 | Laropiprant | 1 | Terminated | 1 |
| DB00627 | Niacin | 1 | Terminated | 1 |
| DB09302 | Alirocumab | 2 | Completed | 1 |
| DB00973 | Ezetimibe | 2 | Unknown Status | 1 |
| DB14901 | Inclisiran | 2 | Completed | 1 |
| DB12914 | MGL-3196 | 2 | Completed | 1 |
| DB09302 | Alirocumab | 3 | Completed | 2 |
| DB06630 | Anacetrapib | 3 | Completed | 1 |
| DB01076 | Atorvastatin | 3 | Completed | 1 |
| DB12456 | Bococizumab | 3 | Completed | 1 |
| DB05035 | Eprotirome | 3 | Terminated | 1 |
| DB09303 | Evolocumab | 3 | Completed | 1 |
| DB01095 | Fluvastatin | 3 | Completed | 1 |
| DB14901 | Inclisiran | 3 | Active Not Recruiting | 1 |
| DB14901 | Inclisiran | 3 | Completed | 2 |
| DB05528 | Mipomersen | 3 | Completed | 1 |
| DB01098 | Rosuvastatin | 3 | Completed | 1 |
| DB00641 | Simvastatin | 3 | Completed | 1 |
| DB16336 | Tafolecimab | 3 | Completed | 1 |
| DB09302 | Alirocumab | 4 | Terminated | 1 |