Sodium/nucleoside cotransporter 2

Details

Name
Sodium/nucleoside cotransporter 2
Synonyms
  • CNT 2
  • CNT2
  • Concentrative nucleoside transporter 2
  • hCNT2
  • Na(+)/nucleoside cotransporter 2
  • Sodium-coupled nucleoside transporter 2
  • Sodium/purine nucleoside co-transporter
  • Solute carrier family 28 member 2
  • SPNT
Gene Name
SLC28A2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0020807|Sodium/nucleoside cotransporter 2 MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
Number of residues
658
分子量
71925.565
Theoretical pI
Not Available
GO Classification
Functions
nucleoside/purine nucleoside transmembrane transporter activity
Processes
nucleobase-containing compound metabolic process/purine nucleoside transmembrane transport/transmembrane transport
Components
integral component of plasma membrane/membrane/plasma membrane
General Function
Purine nucleoside transmembrane transporter activity
Specific Function
Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
Pfam Domain Function
Transmembrane Regions
80-100 104-123 148-166 172-192 200-220 233-253 260-280 295-314 336-355 362-381 423-443 454-474 529-549 567-587
Cellular Location
Membrane
Gene sequence
>拼箱| BSEQ0020808 |钠/核苷转运蛋白2(SLC28A2) ATGGAGAAAGCAAGTGGAAGACAGTCCATTGCTCTGTCCACAGTGGAGACTGGCACAGTG AACCCGGGGCTGGAGCTCATGGAAAAAGAAGTAGAGCCTGAGGGAAGCAAGAGGACTGAC GCACAAGGACACAGCCTGGGGGATGGACTGGGCCCTTCCACTTACCAGAGGAGGAGTCGG TGGCCTTTCAGCAAAGCAAGAAGTTTCTGCAAAACACACGCCAGCTTGTTCAAGAAGATC CTGTTGGGCCTGTTGTGTTTGGCCTATGCTGCCTATCTCCTGGCAGCTTGCATCTTGAAT TTCCAGAGGGCACTGGCCTTGTTTGTCATCACCTGCTTGGTGATCTTTGTCCTGGTTCAC TCGTTTTTGAAAAAGCTCCTGGGCAAAAAATTAACAAGATGTCTGAAGCCCTTTGAAAAC TCCCGCCTGAGGCTTTGGACGAAATGGGTGTTTGCAGGAGTCTCCTTGGTTGGCCTTATA CTGTGGTTGGCTTTAGACACAGCCCAAAGGCCAGAGCAGCTGATCCCCTTTGCAGGAATC TGCATGTTCATCCTTATCCTCTTTGCCTGCTCCAAACACCACAGCGCAGTGTCCTGGAGG ACAGTGTTTTCGGGCCTAGGTCTTCAATTTGTCTTTGGGATCTTGGTCATCAGAACTGAT CTTGGATATACTGTATTTCAGTGGCTGGGAGAGCAGGTCCAGATTTTCCTGAACTACACT GTGGCCGGCTCCAGTTTTGTCTTTGGGGATACACTGGTCAAGGATGTCTTTGCTTTTCAG GCCTTACCAATCATCATTTTCTTTGGATGTGTGGTGTCCATTCTCTACTACCTGGGCCTT GTGCAATGGGTAGTTCAGAAGGTCGCCTGGTTTTTACAAATCACTATGGGCACCACTGCT ACAGAGACCCTGGCTGTGGCAGGAAACATCTTTGTGGGTATGACAGAGGCACCTCTGCTC ATCCGTCCCTACCTTGGGGACATGACACTCTCTGAAATCCATGCGGTGATGACTGGAGGG TTTGCCACCATTTCTGGCACTGTGCTGGGAGCCTTCATAGCCTTTGGGGTTGATGCATCA TCCCTGATTTCTGCCTCTGTGATGGCCGCCCCTTGTGCTCTCGCCTCATCAAAGCTAGCG TATCCGGAAGTGGAGGAGTCCAAGTTCAAGAGTGAGGAGGGGGTAAAGCTGCCCCGTGGG AAGGAGAGGAATGTCCTGGAAGCTGCCAGCAACGGAGCCGTAGATGCCATAGGCCTTGCT ACTAATGTAGCAGCCAACCTGATTGCCTTTTTGGCTGTGTTGGCCTTCATCAATGCTGCC CTCTCCTGGCTGGGGGAATTGGTGGACATACAGGGGCTCACTTTCCAGGTCATCTGCTCC TATCTCCTAAGGCCCATGGTTTTCATGATGGGTGTAGAGTGGACAGACTGTCCAATGGTG GCTGAGATGGTGGGAATCAAGTTCTTCATAAATGAGTTTGTGGCTTATCAGCAACTGTCT CAATACAAGAACAAACGTCTCTCTGGAATGGAGGAGTGGATTGAGGGAGAGAAACAGTGG ATTTCTGTGAGAGCTGAAATCATTACAACATTTTCACTCTGTGGATTTGCCAATCTTAGT TCCATAGGAATCACACTTGGAGGCTTGACATCAATAGTACCTCACCGGAAGAGTGACTTG TCCAAGGTTGTGGTCAGGGCCCTCTTCACAGGGGCCTGTGTATCCCTTATCAGTGCCTGT ATGGCAGGAATCCTCTATGTCCCCAGGGGAGCTGAAGCTGACTGTGTCTCCTTCCCAAAC ACAAGTTTCACCAATAGAACCTATGAGACCTACATGTGCTGCAGAGGGCTCTTTCAGAGT ACTTCTCTGAATGGCACCAACCCTCCTTCTTTTTCTGGTCCCTGGGAAGATAAGGAGTTC AGTGCTATGGCCCTTACTAACTGCTGTGGATTCTACAACAATACCGTCTGTGCCTAA
Chromosome Location
15
Locus
Not Available
External Identifiers
Resource Link
UniProtKB ID O43868
UniProtKB Entry Name S28A2_HUMAN
HGNC ID HGNC:11002
General References
  1. 苏王J,科幻、梳妆台MJ Schaner我,华盛顿CB, Giacomini KM: Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am J Physiol. 1997 Dec;273(6 Pt 2):F1058-65. [Article]
  2. Ritzel MW, Yao SY, Ng AM, Mackey JR, Cass CE, Young JD: Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol Membr Biol. 1998 Oct-Dec;15(4):203-11. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Loewen SK, Ng AM, Yao SY, Cass CE, Baldwin SA, Young JD: Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. J Biol Chem. 1999 Aug 27;274(35):24475-84. [Article]
  6. Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM: Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenet Genomics. 2005 Feb;15(2):83-90. [Article]
  7. Li L, Tan CM, Koo SH, Chong KT, Lee EJ: Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics. 2007 Sep;17(9):783-6. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB01033 Mercaptopurine approved unknown substrate Details
DB09327 Tegafur-uracil approved, investigational no substrate Details
DB00640 Adenosine approved, investigational unknown substrate Details