Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Details

Name
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Synonyms
  • 1.1.1.8
  • GPD-C
Gene Name
GPD1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0036971|Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHEN VKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIK GVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKEL MQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAK LFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGP ETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM
Number of residues
349
分子量
37567.4
Theoretical pI
6.1
GO Classification
Functions
glycerol-3-phosphate dehydrogenase [NAD+] activity/glycerol-3-phosphate dehydrogenase activity/NAD binding
Processes
cellular lipid metabolic process/cellular response to cAMP/cellular response to tumor necrosis factor/gluconeogenesis/glycerol-3-phosphate catabolic process/glycerophosphate shuttle/glycerophospholipid biosynthetic process/phosphatidic acid biosynthetic process/phospholipid metabolic process/positive regulation of glycolytic process/small molecule metabolic process/triglyceride biosynthetic process
Components
cytosol/extracellular exosome/glycerol-3-phosphate dehydrogenase complex/mitochondrion
General Function
Nad binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010201|Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD1) ATGGCTAGCAAGAAAGTCTGCATTGTAGGCTCCGGGAACTGGGGCTCAGCCATCGCCAAG ATCGTGGGTGGCAATGCAGCCCAGCTGGCACAGTTTGACCCACGGGTGACCATGTGGGTA TTTGAGGAAGACATTGGAGGCAAAAAGCTGACTGAGATCATCAACACGCAGCATGAGAAT GTCAAATACCTGCCAGGGCACAAGTTGCCCCCAAATGTGTTCATCGGCAAGATCTGTGAC CAGCTCAAGGGCCATCTGAAGGCAAACGCCACTGGCATATCTCTTATTAAGGGGGTAGAC GAGGGCCCCAATGGGCTGAAGCTCATCTCGGAAGTGATTGGGGAGCGCCTCGGCATCCCC ATGAGTGTGCTGATGGGGGCCAACATTGCCAGCGAGGTGGCTGATGAGAAGTTCTGTGAG ACAACCATTGGCTGCAAGGACCCGGCCCAGGGACAACTCCTGAAAGAGCTGATGCAGACA CCAAACTTCCGTATCACAGTGGTGCAAGAGGTGGACACAGTAGAGATCTGTGGAGCCTTA AAGAATGTAGTGGCCGTGGGGGCTGGCTTCTGTGATGGCCTGGGCTTTGGCGACAACACC AAGGCGGCAGTGATCCGGCTGGGACTCATGGAGATGATAGCCTTCGCCAAGCTCTTCTGC AGTGGCCCTGTGTCCTCTGCCACCTTCTTGGAGAGCTGTGGTGTTGCTGACCTGATCACT ACCTGCTATGGAGGGCGGAACCGGAAAGTGGCTGAGGCCTTTGCGCGTACAGGAAAGTCC ATTGAGCAGCTGGAGAAAGAGTTGCTGAATGGGCAGAAACTGCAGGGGCCCGAGACAGCC CGGGAGCTATACAGCATCCTCCAGCACAAGGGCCTGGTAGACAAGTTTCCCTTGTTCATG GCTGTGTACAAGGTGTGCTACGAGGGCCAGCCAGTGGGTGAATTCATCCACTGCCTGCAG AATCATCCAGAACATATGTGA
Chromosome Location
12
Locus
12q12-q13
External Identifiers
Resource Link
UniProtKB ID P21695
UniProtKB Entry Name GPDA_HUMAN
GenBank Protein ID 508487
GenBank Gene ID L34041
GenAtlas ID GPD1
HGNC ID HGNC:4455
一般References
  1. Menaya J, Gonzalez-Manchon C, Parrilla R, Ayuso MS: Molecular cloning, sequencing and expression of a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase. Biochim Biophys Acta. 1995 May 17;1262(1):91-4. [Article]
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  5. Gwynn B, Lyford KA, Birkenmeier EH: Sequence conservation and structural organization of the glycerol-3-phosphate dehydrogenase promoter in mice and humans. Mol Cell Biol. 1990 Oct;10(10):5244-56. [Article]
  6. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
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  8. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB00157 NADH approved, nutraceutical unknown Details
DB00331 Metformin approved unknown inhibitor Details