G1/S-specific cyclin-D1

Details

Name
G1/S-specific cyclin-D1
Synonyms
  • B-cell lymphoma 1 protein
  • BCL-1
  • BCL-1 oncogene
  • BCL1
  • PRAD1
  • PRAD1 oncogene
Gene Name
CCND1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019051|G1/S-specific cyclin-D1 MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Number of residues
295
Molecular Weight
33728.74
Theoretical pI
4.68
GO Classification
Functions
cyclin-dependent protein serine/threonine kinase regulator activity/enzyme binding/histone deacetylase binding/proline-rich region binding/protein kinase activity/protein kinase binding/transcription corepressor activity/transcription factor binding
Processes
canonical Wnt signaling pathway/cell division/cellular response to DNA damage stimulus/chromatin organization/endoplasmic reticulum unfolded protein response/fat cell differentiation/G1/S transition of mitotic cell cycle/lactation/Leydig cell differentiation/liver development/mammary gland alveolus development/mammary gland epithelial cell proliferation/mitotic cell cycle/mitotic G1 DNA damage checkpoint/negative regulation of cell cycle arrest/负调节上皮细胞的差异tion/negative regulation of transcription from RNA polymerase II promoter/negative regulation of Wnt signaling pathway/Notch signaling pathway/organ regeneration/positive regulation of cyclin-dependent protein serine/threonine kinase activity/positive regulation of G2/M transition of mitotic cell cycle/positive regulation of mammary gland epithelial cell proliferation/positive regulation of protein phosphorylation/re-entry into mitotic cell cycle/response to calcium ion/response to corticosterone/response to drug/response to estradiol/response to ethanol/response to iron ion/response to magnesium ion/response to organonitrogen compound/response to UV-A/response to vitamin E/response to X-ray/transcription, DNA-templated
Components
bicellular tight junction/cyclin-dependent protein kinase holoenzyme complex/cytosol/intracellular/membrane/nucleoplasm/nucleus/transcriptional repressor complex
General Function
Transcription factor binding
Specific Function
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0019052|G1/S-specific cyclin-D1 (CCND1) ATGGAACACCAGCTCCTGTGCTGCGAAGTGGAAACCATCCGCCGCGCGTACCCCGATGCC AACCTCCTCAACGACCGGGTGCTGCGGGCCATGCTGAAGGCGGAGGAGACCTGCGCGCCC TCGGTGTCCTACTTCAAATGTGTGCAGAAGGAGGTCCTGCCGTCCATGCGGAAGATCGTC GCCACCTGGATGCTGGAGGTCTGCGAGGAACAGAAGTGCGAGGAGGAGGTCTTCCCGCTG GCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAAAAAGAGCCGCCTGCAG CTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATCCCCCTGACG GCCGAGAAGCTGTGCATCTACACCGACAACTCCATCCGGCCCGAGGAGCTGCTGCAAATG GAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCAATGACCCCGCACGATTTC ATTGAACACTTCCTCTCCAAAATGCCAGAGGCGGAGGAGAACAAACAGATCATCCGCAAA CACGCGCAGACCTTCGTTGCCCTCTGTGCCACAGATGTGAAGTTCATTTCCAATCCGCCC TCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCC AACAACTTCCTGTCCTACTACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGAC CCGGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGTCAAGCCTGCGC CAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAG GTGGACCTGGCTTGCACACCCACCGACGTGCGGGACGTGGACATCTGA
Chromosome Location
11
Locus
11q13
External Identifiers
Resource Link
UniProtKB ID P24385
UniProtKB Entry Name CCND1_HUMAN
GenBank Protein ID 35632
GenBank Gene ID X59798
GenAtlas ID CCND1
HGNC ID HGNC:1582
General References
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  8. Bates S, Bonetta L, MacAllan D, Parry D, Holder A, Dickson C, Peters G: CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene. 1994 Jan;9(1):71-9. [Article]
  9. Chesi M, Bergsagel PL, Brents LA, Smith CM, Gerhard DS, Kuehl WM: Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. Blood. 1996 Jul 15;88(2):674-81. [Article]
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  14. Wang HW, Muguira M, Liu WD, Zhang T, Chen C, Aucoin R, Breslin MB, Lan MS: Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription. J Endocrinol. 2008 Jul;198(1):29-39. doi: 10.1677/JOE-08-0001. Epub 2008 Apr 16. [Article]
  15. 刘张T, WD Saunee NA,布雷斯林MB,兰女士:子nc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest. J Biol Chem. 2009 Feb 27;284(9):5574-81. doi: 10.1074/jbc.M808843200. Epub 2009 Jan 5. [Article]
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  18. Mori T, Ikeda DD, Fukushima T, Takenoshita S, Kochi H: NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. Cell Cycle. 2011 Oct 1;10(19):3284-99. doi: 10.4161/cc.10.19.17176. Epub 2011 Oct 1. [Article]
  19. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB01169 Arsenic trioxide approved, investigational yes antagonist Details
DB11718 Encorafenib approved, investigational yes inhibitor Details
DB00945 Acetylsalicylic acid approved, vet_approved unknown downregulator Details
DB11752 Bryostatin 1 investigational unknown inhibitor Details