Thymidine kinase

Details

Name
Thymidine kinase
Synonyms
  • 2.7.1.21
通用电气ne Name
TK
Organism
EHV-4
Amino acid sequence
>lcl|BSEQ0016617|Thymidine kinase MAACVPPGEAPRSASGTPTRRQVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPE PMAYWRTLFETDVISGIYDTQNRKQQGNLAVDDAALITAHYQSRFTTPYLILHDHTCTLF GGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIV VTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPT SCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRN LNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
Number of residues
352
分子量
38784.035
Theoretical pI
7.19
GO Classification
Functions
ATP binding/thymidine kinase activity
Processes
DNA biosynthetic process/TMP biosynthetic process
通用电气neral Function
Thymidine kinase activity
Specific Function
In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
通用电气ne sequence
>lcl|BSEQ0003820|1059 bp ATGGCTGCTTGCGTACCCCCGGGAGAAGCTCCACGAAGCGCCAGCGGAACGCCCACCCGG CGGCAAGTAACAATAGTTAGAATTTACCTCGATGGAGTTTATGGCATCGGTAAGAGCACG ACGGGACGAGTTATGGCATCGGCTGCTAGCGGAGGAAGTCCAACTCTATACTTTCCAGAG CCTATGGCGTACTGGCGGACTCTTTTTGAAACGGACGTAATTAGTGGTATTTACGACACC CAAAACCGGAAACAGCAGGGAAATTTGGCCGTTGATGACGCGGCATTAATAACTGCGCAT TACCAAAGCCGCTTTACCACGCCCTACCTGATACTCCACGATCACACTTGTACGTTGTTT GGGGGAAACAGCCTACAGCGTGGAACACAACCGGACCTGACCCTTGTGTTTGACCGCCAC CCGGTCGCCTCTACCGTATGCTTTCCAGCAGCCCGCTACCTACTCGGTGACATGTCAATG TGCGCGCTAATGGCTATGGTTGCTACTCTACCAAGAGAACCCCAGGGTGGTAACATTGTG GTTACCACCCTAAATGTAGAGGAGCATATACGGAGACTGCGTACGCGGGCTAGAATAGGA GAACAAATTGACATTACGCTGATTGCTACATTGCGAAATGTGTACTTTATGCTAGTTAAT ACATGTCACTTTTTGCGCTCTGGGCGAGTTTGGCGCGACGGTTGGGGTGAGCTACCCACT TCCTGTGGGGCTTATAAGCATCGCGCCACACAGATGGACGCCTTCCAAGAGCGCGTTTCA CCGGAGCTGGGCGACACTCTGTTTGCCCTGTTTAAAACTCAAGAACTGCTAGACGATCGC GGTGTAATATTGGAAGTTCACGCTTGGGCGTTGGACGCGCTTATGCTAAAACTGCGTAAC CTGAATGTTTTCAGTGCCGATTTAAGTGGTACACCGCGACAATGTGCAGCTGTTGTAGAG TCTTTGCTGCCACTTATGAGCAGCACCTTATCAGATTTTGATTCCGCCTCTGCTTTAGAG CGGGCGGCACGCACCTTTAACGCGGAGATGGGCGTCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
Resource Link
UniProtKB ID P24425
UniProtKB Entry Name KITH_EHV4
通用电气nBank Protein ID 221822
通用电气nBank Gene ID D14486
通用电气neral References
  1. Nicolson L, Cullinane AA, Onions DE: The nucleotide sequence of the equine herpesvirus 4 thymidine kinase gene. J Gen Virol. 1990 Aug;71 ( Pt 8):1801-5. [Article]
  2. Gardberg A, Shuvalova L, Monnerjahn C, Konrad M, Lavie A: Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases. Structure. 2003 Oct;11(10):1265-77. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB03280 p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate experimental unknown Details
DB04485 Thymidine experimental, investigational unknown Details