Endothelin-1 receptor

Details

Name
Endothelin-1 receptor
Synonyms
  • Endothelin A receptor
  • ET-A
  • ETA
  • ETA-R
  • ETRA
  • hET-AR
Gene Name
EDNRA
Organism
Humans
Amino acid sequence
>拼箱| BSEQ0001040 | Endothelin-1受体METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS SHKDSMN
Number of residues
427
Molecular Weight
48721.76
Theoretical pI
8.41
GO Classification
Functions
endothelin receptor activity/phosphatidylinositol phospholipase C activity
Processes
activation of adenylate cyclase activity/activation of phospholipase C activity/artery smooth muscle contraction/cell proliferation/endothelin receptor signaling pathway/enteric nervous system development/G-protein coupled receptor signaling pathway/glucose transport/head development/heart development/in utero embryonic development/negative regulation of cAMP biosynthetic process/neural crest cell development/patterning of blood vessels/positive regulation of cytosolic calcium ion concentration/regulation of blood pressure/respiratory gaseous exchange/response to hypoxia/signal transduction/smooth muscle contraction/vasoconstriction
Components
cytosol/integral component of plasma membrane/plasma membrane
General Function
Phosphatidylinositol phospholipase c activity
Specific Function
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Pfam Domain Function
Transmembrane Regions
81-102 113-132 160-181 206-229 257-278 307-328 348-372
Cellular Location
Cell membrane
Gene sequence
>拼箱| BSEQ0010366 | Endothelin-1受体(EDNRA ATG)GAAACCCTTTGCCTCAGGGCATCCTTTTGGCTGGCACTGGTTGGATGTGTAATCAGT GATAATCCTGAGAGATACAGCACAAATCTAAGCAATCATGTGGATGATTTCACCACTTTT CGTGGCACAGAGCTCAGCTTCCTGGTTACCACTCATCAACCCACTAATTTGGTCCTACCC AGCAATGGCTCAATGCACAACTATTGCCCACAGCAGACTAAAATTACTTCAGCTTTCAAA TACATTAACACTGTGATATCTTGTACTATTTTCATCGTGGGAATGGTGGGGAATGCAACT CTGCTCAGGATCATTTACCAGAACAAATGTATGAGGAATGGCCCCAACGCGCTGATAGCC AGTCTTGCCCTTGGAGACCTTATCTATGTGGTCATTGATCTCCCTATCAATGTATTTAAG TTCTACCAAGATGTAAAGGACTGGTGGCTCTTCGGGTTCTATTTCTGTATGCCCTTGGTG TGCACTGCGATCTTCTACACCCTCATGACTTGTGAGATGTTGAACAGAAGGAATGGCAGC TTGAGAATTGCCCTCAGTGAACATCTTAAGCAGCGTCGAGAAGTGGCAAAAACAGTTTTC TGCTTGGTTGTAATTTTTGCTCTTTGCTGGTTCCCTCTTCATTTAAGCCGTATATTGAAG AAAACTGTGTATAACGAGATGGACAAGAACCGATGTGAATTACTTAGTTTCTTACTGCTC ATGGATTACATCGGTATTAACTTGGCAACCATGAATTCATGTATAAACCCCATAGCTCTG TATTTTGTGAGCAAGAAATTTAAAAATTGTTTCCAGTCATGCCTCTGCTGCTGCTGTTAC CAGTCCAAAAGTCTGATGACCTCGGTCCCCATGAACGGAACAAGCATCCAGTGGAAGAAC CACGATCAAAACAACCACAACACAGACCGGAGCAGCCATAAGGACAGCATGAACTGA
Chromosome Location
4
Locus
4q31.23
External Identifiers
Resource Link
UniProtKB ID P25101
UniProtKB Entry Name EDNRA_HUMAN
GenBank Protein ID 238636
GenBank Gene ID S63938
GenAtlas ID EDNRA
HGNC ID HGNC:3179
General References
  1. Adachi M, Yang YY, Furuichi Y, Miyamoto C: Cloning and characterization of cDNA encoding human A-type endothelin receptor. Biochem Biophys Res Commun. 1991 Nov 14;180(3):1265-72. [Article]
  2. Cyr C, Huebner K, Druck T, Kris R: Cloning and chromosomal localization of a human endothelin ETA receptor. Biochem Biophys Res Commun. 1991 Nov 27;181(1):184-90. [Article]
  3. Hosoda K, Nakao K, Hiroshi-Arai, Suga S, Ogawa Y, Mukoyama M, Shirakami G, Saito Y, Nakanishi S, Imura H: Cloning and expression of human endothelin-1 receptor cDNA. FEBS Lett. 1991 Aug 5;287(1-2):23-6. [Article]
  4. Arai H, Nakao K, Hosoda K, Ogawa Y, Nakagawa O, Komatsu Y, Imura H: [Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]. Jpn Circ J. 1992;56 Suppl 5:1303-7. [Article]
  5. Elshourbagy NA, Korman DR, Wu HL, Sylvester DR, Lee JA, Nuthalaganti P, Bergsma DJ, Kumar CS, Nambi P: Molecular characterization and regulation of the human endothelin receptors. J Biol Chem. 1993 Feb 25;268(6):3873-9. [Article]
  6. Hosoda K, Nakao K, Tamura N, Arai H, Ogawa Y, Suga S, Nakanishi S, Imura H: Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor. J Biol Chem. 1992 Sep 15;267(26):18797-804. [Article]
  7. Hayzer DJ, Rose PM, Lynch JS, Webb ML, Kienzle BK, Liu EC, Bogosian EA, Brinson E, Runge MS: Cloning and expression of a human endothelin receptor: subtype A. Am J Med Sci. 1992 Oct;304(4):231-8. [Article]
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  15. Gordon CT, Weaver KN, Zechi-Ceide RM, Madsen EC, Tavares AL, Oufadem M, Kurihara Y, Adameyko I, Picard A, Breton S, Pierrot S, Biosse-Duplan M, Voisin N, Masson C, Bole-Feysot C, Nitschke P, Delrue MA, Lacombe D, Guion-Almeida ML, Moura PP, Garib DG, Munnich A, Ernfors P, Hufnagel RB, Hopkin RJ, Kurihara H, Saal HM, Weaver DD, Katsanis N, Lyonnet S, Golzio C, Clouthier DE, Amiel J: Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. Am J Hum Genet. 2015 Apr 2;96(4):519-31. doi: 10.1016/j.ajhg.2015.01.015. Epub 2015 Mar 12. [Article]
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB00559 Bosentan approved, investigational yes antagonist Details
DB04883 Darusentan investigational unknown Details
DB12548 Sparsentan investigational unknown Details
DB05290 SPP 301 investigational unknown Details
DB05367 Actelion-1 investigational unknown Details
DB06403 Ambrisentan approved, investigational yes antagonist Details
DB06199 Atrasentan investigational unknown Details
DB06558 Tezosentan investigational unknown Details
DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACID experimental unknown Details
DB06268 Sitaxentan approved, investigational, withdrawn yes antagonist Details
DB08932 Macitentan approved yes antagonist Details
DB00945 Acetylsalicylic acid approved, vet_approved unknown inhibitor Details
DB06677 Clazosentan investigational unknown Details
DB06460 Enrasentan investigational unknown Details