Streptogramin A acetyltransferase

Details

Name
Streptogramin A acetyltransferase
Synonyms
  • 2.3.1.-
  • satA
  • Vat(D)
  • Virginiamycin acetyltransferase D
通用电气ne Name
vatD
Organism
Enterococcus faecium
Amino acid sequence
>lcl|BSEQ0021973|Streptogramin A acetyltransferase MGPNPMKMYPIEGNKSVQFIKPILEKLENVEVGEYSYYDSKNGETFDKQILYHYPILNDK LKIGKFCSIGPGVTIIMNGANHRMDGSTYPFNLFGNGWEKHMPKLDQLPIKGDTIIGNDV WIGKDVVIMPGVKIGDGAIVAANSVVVKDIAPYMLAGGNPANEIKQRFDQDTINQLLDIK WWNWPIDIINENIDKILDNSIIREVIWKK
Number of residues
209
分子量
23649.22
Theoretical pI
5.75
GO Classification
Functions
transferase activity, transferring acyl groups
Processes
response to antibiotic
通用电气neral Function
Transferase activity, transferring acyl groups
Specific Function
Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
通用电气ne sequence
>lcl|BSEQ0002464|630 bp ATGGGTCCGAATCCTATGAAAATGTATCCTATAGAAGGAAACAAATCAGTACAATTTATC AAACCTATTTTAGAAAAATTAGAAAATGTTGAGGTTGGAGAATACTCATATTATGATTCT AAGAATGGAGAAACTTTTGATAAGCAAATTTTATATCATTATCCAATCTTAAACGATAAG TTAAAAATAGGTAAATTTTGCTCAATAGGACCAGGTGTAACTATTATTATGAATGGAGCA AATCATAGAATGGATGGCTCAACATATCCATTTAATTTATTTGGTAATGGATGGGAGAAA CATATGCCAAAATTAGATCAACTACCTATTAAGGGGGATACAATAATAGGTAATGATGTA TGGATAGGAAAAGATGTTGTAATTATGCCAGGAGTAAAAATCGGGGATGGTGCAATAGTA GCTGCTAATTCTGTTGTTGTAAAAGATATAGCGCCATACATGTTAGCTGGAGGAAATCCT GCTAACGAAATAAAACAAAGATTTGATCAAGATACAATAAATCAGCTGCTTGATATAAAA TGGTGGAATTGGCCAATAGACATTATTAATGAGAATATAGATAAAATTCTTGATAATAGC ATCATTAGAGAAGTCATATGGAAAAAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
Resource Link
UniProtKB ID P50870
UniProtKB Entry Name VATD_ENTFC
通用电气nBank Protein ID 433715
通用电气nBank Gene ID L12033
通用电气neral References
  1. Rende-Fournier R, Leclercq R, Galimand M, Duval J, Courvalin P: Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145. Antimicrob Agents Chemother. 1993 Oct;37(10):2119-25. [Article]
  2. Sugantino M, Roderick SL: Crystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics. Biochemistry. 2002 Feb 19;41(7):2209-16. [Article]
  3. Kehoe LE, Snidwongse J, Courvalin P, Rafferty JB, Murray IA: Structural basis of Synercid (quinupristin-dalfopristin) resistance in Gram-positive bacterial pathogens. J Biol Chem. 2003 Aug 8;278(32):29963-70. Epub 2003 May 27. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB01669 Virginiamycin M1 experimental unknown Details
DB01992 Coenzyme A investigational, nutraceutical unknown Details
DB01764 Dalfopristin approved yes inhibitor Details