Ribonuclease UK114
Details
- Name
- Ribonuclease UK114
- Synonyms
-
- 14.5 kDa translational inhibitor protein
- 3.1.-.-
- Heat-responsive protein 12
- p14.5
- PSP
- UK114 antigen homolog
- Gene Name
- HRSP12
- Organism
- Humans
- Amino acid sequence
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>lcl|BSEQ0011180|Ribonuclease UK114 MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALK NMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSR IEIEAVAIQGPLTTASL
- Number of residues
- 137
- 分子量
- 14493.53
- Theoretical pI
- 9.01
- GO Classification
-
Functionsdeaminase activity/endoribonuclease activity, producing 3'-phosphomonoesters/long-chain fatty acid binding/platinum binding/poly(A) RNA binding/transition metal ion binding/xenon atom bindingProcessesbrain development/G1 to G0 transition/kidney development/lung development/negative regulation of epithelial cell proliferation/negative regulation of translation/regulation of translational termination/response to lipid/response to saltComponentscytoplasm/cytosol/extracellular exosome/mitochondrion/nucleus/peroxisome
- General Function
- Xenon atom binding
- Specific Function
- Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).
- Pfam Domain Function
-
- Ribonuc_L-PSP (PF01042)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
-
>lcl|BSEQ0011181|Ribonuclease UK114 (HRSP12) ATGTCGTCCTTGATCAGAAGGGTGATCAGCACCGCGAAAGCCCCAGGGGCCATTGGACCC TACAGTCAAGCTGTATTAGTCGACAGGACCATTTACATTTCAGGACAGATAGGCATGGAC CCTTCAAGTGGACAGCTTGTGTCAGGAGGGGTAGCAGAAGAAGCTAAACAAGCTCTTAAA AACATGGGTGAAATTCTGAAAGCTGCAGGCTGTGACTTCACTAACGTGGTGAAAACAACT GTTCTTCTGGCTGACATAAATGACTTCAATACTGTCAATGAAATCTACAAACAGTATTTC AAGAGTAATTTTCCTGCTAGAGCTGCTTACCAAGTTGCTGCTTTACCCAAAGGCAGCCGA ATTGAAATTGAAGCAGTAGCTATCCAAGGACCACTGACAACGGCATCACTATAA
- Chromosome Location
- 8
- Locus
- 8q22
- External Identifiers
-
Resource Link UniProtKB ID P52758 UniProtKB Entry Name UK114_HUMAN GenBank Protein ID 1177435 GenBank Gene ID X95384 GenAtlas ID HRSP12 HGNC ID HGNC:16897 - 一般References
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- Schmiedeknecht G, Kerkhoff C, Orso E, Stohr J, Aslanidis C, Nagy GM, Knuechel R, Schmitz G: Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation. Eur J Biochem. 1996 Dec 1;242(2):339-51. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
- Manjasetty BA, Delbruck H, Pham DT, Mueller U, Fieber-Erdmann M, Scheich C, Sievert V, Bussow K, Niesen FH, Weihofen W, Loll B, Saenger W, Heinemann U: Crystal structure of Homo sapiens protein hp14.5. Proteins. 2004 Mar 1;54(4):797-800. [Article]
Drug Relations
- Drug Relations
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