Caspase-9

Details

Name
Caspase-9
Synonyms
  • 3.4.22.62
  • APAF-3
  • Apoptotic protease Mch-6
  • Apoptotic protease-activating factor 3
  • CASP-9
  • ICE-LAP6
  • ICE-like apoptotic protease 6
  • MCH6
Gene Name
CASP9
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052487|Caspase-9 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
Number of residues
416
分子量
46280.325
Theoretical pI
Not Available
GO Classification
Functions
cysteine-type肽链内切酶活性/cysteine-type肽链内切酶活性involved in apoptotic process/cysteine-type肽链内切酶活性involved in apoptotic signaling pathway/enzyme activator activity/identical protein binding/peptidase activity/protein kinase binding/SH3 domain binding
Processes
activation of cysteine-type endopeptidase activity involved in apoptotic process/activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c/aging/apoptotic process/cellular response to dexamethasone stimulus/cellular response to DNA damage stimulus/cellular response to UV/extrinsic apoptotic signaling pathway in absence of ligand/glial cell apoptotic process/intrinsic apoptotic signaling pathway in response to DNA damage/kidney development/leukocyte apoptotic process/platelet formation/positive regulation of apoptotic process/positive regulation of neuron apoptotic process/regulation of response to DNA damage stimulus/response to antibiotic/response to cobalt ion/response to estradiol/response to ischemia/response to lipopolysaccharide/signal transduction in response to DNA damage
Components
apoptosome/cytoplasm/cytosol/mitochondrion/nucleus/protein-containing complex
General Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Specific Function
Cysteine-type endopeptidase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0052488|Caspase-9 (CASP9) ATGGACGAAGCGGATCGGCGGCTCCTGCGGCGGTGCCGGCTGCGGCTGGTGGAAGAGCTG CAGGTGGACCAGCTCTGGGACGCCCTGCTGAGCCGCGAGCTGTTCAGGCCCCATATGATC GAGGACATCCAGCGGGCAGGCTCTGGATCTCGGCGGGATCAGGCCAGGCAGCTGATCATA GATCTGGAGACTCGAGGGAGTCAGGCTCTTCCTTTGTTCATCTCCTGCTTAGAGGACACA GGCCAGGACATGCTGGCTTCGTTTCTGCGAACTAACAGGCAAGCAGCAAAGTTGTCGAAG CCAACCCTAGAAAACCTTACCCCAGTGGTGCTCAGACCAGAGATTCGCAAACCAGAGGTT CTCAGACCGGAAACACCCAGACCAGTGGACATTGGTTCTGGAGGATTTGGTGATGTCGGT GCTCTTGAGAGTTTGAGGGGAAATGCAGATTTGGCTTACATCCTGAGCATGGAGCCCTGT GGCCACTGCCTCATTATCAACAATGTGAACTTCTGCCGTGAGTCCGGGCTCCGCACCCGC ACTGGCTCCAACATCGACTGTGAGAAGTTGCGGCGTCGCTTCTCCTCGCTGCATTTCATG GTGGAGGTGAAGGGCGACCTGACTGCCAAGAAAATGGTGCTGGCTTTGCTGGAGCTGGCG CAGCAGGACCACGGTGCTCTGGACTGCTGCGTGGTGGTCATTCTCTCTCACGGCTGTCAG GCCAGCCACCTGCAGTTCCCAGGGGCTGTCTACGGCACAGATGGATGCCCTGTGTCGGTC GAGAAGATTGTGAACATCTTCAATGGGACCAGCTGCCCCAGCCTGGGAGGGAAGCCCAAG CTCTTTTTCATCCAGGCCTGTGGTGGGGAGCAGAAAGACCATGGGTTTGAGGTGGCCTCC ACTTCCCCTGAAGACGAGTCCCCTGGCAGTAACCCCGAGCCAGATGCCACCCCGTTCCAG GAAGGTTTGAGGACCTTCGACCAGCTGGACGCCATATCTAGTTTGCCCACACCCAGTGAC ATCTTTGTGTCCTACTCTACTTTCCCAGGTTTTGTTTCCTGGAGGGACCCCAAGAGTGGC TCCTGGTACGTTGAGACCCTGGACGACATCTTTGAGCAGTGGGCTCACTCTGAAGACCTG CAGTCCCTCCTGCTTAGGGTCGCTAATGCTGTTTCGGTGAAAGGGATTTATAAACAGATG CCTGGTTGCTTTAATTTCCTCCGGAAAAAACTTTTCTTTAAAACATCATAA
Chromosome Location
1
Locus
1p36.21
External Identifiers
Resource Link
UniProtKB ID P55211
UniProtKB Entry Name CASP9_HUMAN
HGNC ID HGNC:1511
一般裁判erences
  1. Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM: ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996 Jul 12;271(28):16720-4. doi: 10.1074/jbc.271.28.16720. [Article]
  2. Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES: The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem. 1996 Oct 25;271(43):27099-106. doi: 10.1074/jbc.271.43.27099. [Article]
  3. Hadano S, Nasir J, Nichol K, Rasper DM, Vaillancourt JP, Sherer SW, Beatty BG, Ikeda JE, Nicholson DW, Hayden MR: Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3. Mamm Genome. 1999 Jul;10(7):757-60. doi: 10.1007/s003359901086. [Article]
  4. Srinivasula SM, Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T, Alnemri ES: Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res. 1999 Mar 1;59(5):999-1002. [Article]
  5. Seol DW, Billiar TR: A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J Biol Chem. 1999 Jan 22;274(4):2072-6. doi: 10.1074/jbc.274.4.2072. [Article]
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB00282 Pamidronic acid approved unknown activator Details