Histone H2B type 1-C/E/F/G/I

Details

Name
Histone H2B type 1-C/E/F/G/I
Synonyms
  • H2B/a
  • H2B/g
  • H2B/h
  • H2B/k
  • H2B/l
  • H2BFA
  • H2BFG
  • H2BFH
  • H2BFK
  • H2BFL
  • Histone H2B.1 A
  • Histone H2B.a
  • Histone H2B.g
  • Histone H2B.h
  • Histone H2B.k
  • Histone H2B.l
Gene Name
HIST1H2BC
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019691|Histone H2B type 1-C/E/F/G/I MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT KYTSSK
Number of residues
126
分子量
13906.035
Theoretical pI
Not Available
GO Classification
Functions
DNA binding
Processes
antibacterial humoral response/chromatin organization/defense response to Gram-positive bacterium/innate immune response in mucosa/nucleosome assembly
Components
cytoplasm/extracellular exosome/extracellular space/nuclear nucleosome/nucleoplasm/nucleosome/nucleus
General Function
Dna binding
Specific Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0019692|Histone H2B type 1-C/E/F/G/I (HIST1H2BC) ATGCCTGAACCTACCAAGTCTGCTCCTGCCCCAAAGAAGGGCTCCAAGAAGGCGGTGACT AAGGCTCAGAAGAAGGACGGGAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTATTCAGTG TATGTGTACAAGGTGCTGAAGCAGGTCCATCCCGACACCGGCATCTCTTCCAAGGCAATG GGGATCATGAATTCCTTCGTCAACGACATCTTCGAGCGCATCGCAGGCGAGGCTTCCCGC CTGGCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGC CTGCTGCTTCCGGGGGAGCTGGCCAAGCACGCCGTGTCGGAGGGCACCAAGGCCGTCACC AAGTACACCAGTTCCAAGTAA
Chromosome Location
6
Locus
Not Available
External Identifiers
Resource Link
UniProtKB ID P62807
UniProtKB Entry Name H2B1C_HUMAN
HGNC ID HGNC:4757
General References
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB09130 Copper approved, investigational unknown Details