NAD(P)H dehydrogenase (quinone)

Details

Name
NAD(P)H dehydrogenase (quinone)
Synonyms
  • 1.6.5.2
  • lpdA-2
  • NAD(P)H quinone reductase
  • NAD(P)H: menadione oxidoreductase
  • NADH-menadione reductase
Gene Name
lpdA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051195|NAD(P)H dehydrogenase (quinone) MVTRIVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGL RTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELI DSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDA LPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRL FKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIGSVPNTSGLGLERVGIQLGRGNYLT VDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVFTRP EIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGVVVA PIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHDDLDCTAAQDAAE QLALVPHHLPTSN
Number of residues
493
Molecular Weight
51488.44
Theoretical pI
Not Available
GO Classification
Functions
flavin adenine dinucleotide binding/NAD(P)H dehydrogenase (quinone) activity/NADP+ binding/oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Processes
cell redox homeostasis/oxidation-reduction process/pathogenesis
Components
cell
General Function
May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4-benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH.
Specific Function
Flavin adenine dinucleotide binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>拼箱| BSEQ0051196 | NAD (P) H脱氢酶(醌)(lpdA) GTGGTGACCCGCATCGTGATCCTCGGTGGCGGCCCGGCCGGTTACGAGGCCGCACTGGTG GCCGCCACCTCACACCCGGAAACAACCCAAGTTACCGTGATTGACTGCGACGGCATCGGC GGGGCTGCCGTACTGGACGACTGTGTGCCGTCGAAGACGTTCATCGCCTCCACCGGGCTG CGTACCGAACTGCGCCGAGCGCCGCACCTGGGCTTTCATATCGACTTCGACGACGCCAAG ATCTCGTTGCCGCAAATCCATGCCCGGGTCAAGACGCTGGCCGCCGCACAGTCGGCCGAC ATCACCGCCCAGCTGCTCAGCATGGGGGTTCAGGTGATCGCCGGCCGGGGCGAGTTGATC GACTCCACACCGGGTCTGGCGCGCCATCGCATTAAGGCGACCGCCGCCGACGGCTCCACC AGTGAGCATGAGGCCGACGTCGTGCTGGTCGCCACCGGCGCCAGCCCGCGGATCCTGCCG TCGGCCCAGCCGGACGGTGAGCGCATTCTGACCTGGCGGCAGCTCTACGACTTGGACGCG TTGCCCGACCACCTCATCGTGGTGGGCTCCGGGGTTACCGGTGCTGAGTTCGTGGACGCC TATACCGAATTGGGGGTGCCGGTCACGGTGGTGGCCAGCCAGGACCACGTGCTGCCGTAT GAGGACGCTGACGCTGCGCTGGTCCTGGAAGAGTCGTTCGCCGAACGGGGAGTCCGGCTG TTCAAAAATGCCCGGGCAGCATCGGTCACCCGCACCGGGGCCGGGGTGCTCGTCACGATG ACCGACGGTCGCACCGTCGAGGGCAGCCACGCCCTGATGACCATCGGGTCGGTGCCCAAC ACCAGCGGCCTGGGCCTGGAACGGGTCGGCATCCAGCTTGGCCGGGGCAATTACCTGACC GTGGACCGGGTGTCGCGGACGTTGGCGACCGGCATCTACGCCGCGGGCGACTGCACGGGT TTGCTGCCCCTGGCGTCGGTCGCCGCAATGCAGGGCCGCATCGCGATGTACCACGCGCTG GGGGAGGGCGTCAGCCCGATCCGGTTACGCACGGTGGCCGCGACGGTTTTCACCAGGCCC GAGATCGCCGCGGTCGGGGTGCCGCAATCGGTCATCGACGCCGGTTCGGTGGCCGCCCGG ACCATCATGCTGCCGTTACGAACCAACGCGCGCGCCAAGATGTCGGAGATGCGTCACGGG TTCGTCAAGATCTTCTGCCGGCGGTCCACCGGCGTTGTGATCGGCGGCGTGGTGGTGGCG CCGATCGCATCGGAGCTGATCCTGCCCATCGCCGTAGCCGTTCAGAACCGCATCACCGTC AACGAGCTGGCCCAGACACTGGCCGTTTACCCATCGTTGTCGGGTTCGATAACCGAGGCG GCCCGCCGGCTGATGGCGCACGACGATCTGGACTGCACGGCAGCTCAAGACGCGGCTGAA CAACTAGCCTTGGTGCCACACCACCTACCGACGAGTAACTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
Resource Link
UniProtKB ID P9WHH7
UniProtKB Entry Name LPDA_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. 说明P,斯利瓦斯塔瓦年代,斯利瓦斯塔瓦,Srivastava M, Srivastava BS, Srivastava R: Rv3303c of Mycobacterium tuberculosis protects tubercle bacilli against oxidative stress in vivo and contributes to virulence in mice. Microbes Infect. 2006 Nov-Dec;8(14-15):2855-62. Epub 2006 Oct 20. [Article]
  3. Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  5. Argyrou A, Vetting MW, Blanchard JS: Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis. J Biol Chem. 2004 Dec 10;279(50):52694-702. Epub 2004 Sep 29. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB03147 Flavin adenine dinucleotide approved unknown Details