Aspartyl/asparaginyl beta-hydroxylase
Details
- Name
- Aspartyl/asparaginyl beta-hydroxylase
- Synonyms
-
- 1.14.11.16
- ASP beta-hydroxylase
- Aspartate beta-hydroxylase
- BAH
- Peptide-aspartate beta-dioxygenase
- Gene Name
- ASPH
- Organism
- Humans
- Amino acid sequence
-
>lcl|BSEQ0037038|Aspartyl/asparaginyl beta-hydroxylase MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMV IALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVP PEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHVEGEDLQQEDGPTGEPQ QEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSE PVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSI FPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEA VNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLK LSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEV LSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGN KEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDE GLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGC RRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFD DSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI
- Number of residues
- 758
- 分子量
- 85862.095
- Theoretical pI
- 4.67
- GO Classification
-
Functionscalcium ion binding/electron carrier activity/ion channel binding/peptide-aspartate beta-dioxygenase activity/structural constituent of muscle/structural molecule activityProcessesactivation of cysteine-type endopeptidase activity/activation of store-operated calcium channel activity/calcium ion transmembrane transport/cellular response to calcium ion/detection of calcium ion/face morphogenesis/ion transmembrane transport/limb morphogenesis/muscle contraction/negative regulation of cell proliferation/palate development/pattern specification process/peptidyl-aspartic acid hydroxylation/positive regulation of calcium ion transport into cytosol/positive regulation of intracellular protein transport/positive regulation of proteolysis/positive regulation of ryanodine-sensitive calcium-release channel activity/positive regulation of transcription, DNA-templated/regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion/regulation of cell communication by electrical coupling/regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity/regulation of protein depolymerization/regulation of protein stability/regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum/regulation of ryanodine-sensitive calcium-release channel activity/response to ATP/transmembrane transportComponentscalcium channel complex/cortical endoplasmic reticulum/endoplasmic reticulum/endoplasmic reticulum membrane/integral component of endoplasmic reticulum membrane/integral component of membrane/junctional sarcoplasmic reticulum membrane/plasma membrane/sarcoplasmic reticulum lumen/sarcoplasmic reticulum membrane
- General Function
- Structural molecule activity
- Specific Function
- Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells.
- Pfam Domain Function
- Transmembrane Regions
- 54-74
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
-
>lcl|BSEQ0020468|Aspartyl/asparaginyl beta-hydroxylase (ASPH) ATGGCTGAAGATAAAGAGACAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGGACTC TCAGGAACTTCATTCTTCACGTGGTTTATGGTGATTGCATTGCTGGGCGTCTGGACATCT GTAGCTGTCGTTTGGTTTGATCTTGTTGACTATGAGGAAGTTCTAGGAAAACTAGGAATC TATGATGCTGATGGTGATGGAGATTTTGATGTGGATGATGCCAAAGTTTTATTAGGACTT AAAGAGAGATCTACTTCAGAGCCAGCAGTCCCGCCAGAAGAGGCTGAGCCACACACTGAG CCCGAGGAGCAGGTTCCTGTGGAGGCAGAACCCCAGAATATCGAAGATGAAGCAAAAGAA CAAATTCAGTCCCTTCTCCATGAAATGGTACACGCAGAACATGTTGAGGGAGAAGACTTG CAACAAGAAGATGGACCCACAGGAGAACCACAACAAGAGGATGATGAGTTTCTTATGGCG ACTGATGTAGATGATAGATTTGAGACCCTGGAACCTGAAGTATCTCATGAAGAAACCGAG CATAGTTACCACGTGGAAGAGACAGTTTCACAAGACTGTAATCAGGATATGGAAGAGATG ATGTCTGAGCAGGAAAATCCAGATTCCAGTGAACCAGTAGTAGAAGATGAAAGATTGCAC CATGATACAGATGATGTAACATACCAAGTCTATGAGGAACAAGCAGTATATGAACCTCTA GAAAATGAAGGGATAGAAATCACAGAAGTAACTGCTCCCCCTGAGGATAATCCTGTAGAA GATTCACAGGTAATTGTAGAAGAAGTAAGCATTTTTCCTGTGGAAGAACAGCAGGAAGTA CCACCAGAAACAAATAGAAAAACAGATGATCCAGAACAAAAAGCAAAAGTTAAGAAAAAG AAGCCTAAACTTTTAAATAAATTTGATAAGACTATTAAAGCTGAACTTGATGCTGCAGAA AAACTCCGTAAAAGGGGAAAAATTGAGGAAGCAGTGAATGCATTTAAAGAACTAGTACGC AAATACCCTCAGAGTCCACGAGCAAGATATGGGAAGGCGCAGTGTGAGGATGATTTGGCT GAGAAGAGGAGAAGTAATGAGGTGCTACGTGGAGCCATCGAGACCTACCAAGAGGTGGCC AGCCTACCTGATGTCCCTGCAGACCTGCTGAAGCTGAGTTTGAAGCGTCGCTCAGACAGG CAACAATTTCTAGGTCATATGAGAGGTTCCCTGCTTACCCTGCAGAGATTAGTTCAACTA TTTCCCAATGATACTTCCTTAAAAAATGACCTTGGCGTGGGATACCTCTTGATAGGAGAT AATGACAATGCAAAGAAAGTTTATGAAGAGGTGCTGAGTGTGACACCTAATGATGGCTTT GCTAAAGTCCATTATGGCTTCATCCTGAAGGCACAGAACAAAATTGCTGAGAGCATCCCA TATTTAAAGGAAGGAATAGAATCCGGAGATCCTGGCACTGATGATGGGAGATTTTATTTC CACCTGGGGGATGCCATGCAGAGGGTTGGGAACAAAGAGGCATATAAGTGGTATGAGCTT GGGCACAAGAGAGGACACTTTGCATCTGTCTGGCAACGCTCACTCTACAATGTGAATGGA CTGAAAGCACAGCCTTGGTGGACCCCAAAAGAAACGGGCTACACAGAGTTAGTAAAGTCT TTAGAAAGAAACTGGAAGTTAATCCGAGATGAAGGCCTTGCAGTGATGGATAAAGCCAAA GGTCTCTTCCTGCCTGAGGATGAAAACCTGAGGGAAAAAGGGGACTGGAGCCAGTTCACG CTGTGGCAGCAAGGAAGAAGAAATGAAAATGCCTGCAAAGGAGCTCCTAAAACCTGTACC TTACTAGAAAAGTTCCCCGAGACAACAGGATGCAGAAGAGGACAGATCAAATATTCCATC ATGCACCCCGGGACTCACGTGTGGCCGCACACAGGGCCCACAAACTGCAGGCTCCGAATG CACCTGGGCTTGGTGATTCCCAAGGAAGGCTGCAAGATTCGATGTGCCAACGAGACCAAG ACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAG GATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCA CAGCAGAGACGCAGCCTTCCAGCAATTTAG
- Chromosome Location
- 8
- Locus
- 8q12.1
- External Identifiers
-
Resource Link UniProtKB ID Q12797 UniProtKB Entry Name ASPH_HUMAN GenBank Protein ID 458032 GenBank Gene ID U03109 GenAtlas ID ASPH HGNC ID HGNC:757 - 一般References
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