2,4-dienoyl-CoA reductase, mitochondrial

Details

Name
2,4-dienoyl-CoA reductase, mitochondrial
Synonyms
  • 1.3.1.34
  • 2,4-dienoyl-CoA reductase [NADPH]
  • 4-enoyl-CoA reductase [NADPH]
  • DECR
  • SDR18C1
  • Short chain dehydrogenase/reductase family 18C member 1
Gene Name
DECR1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006088|2,4-dienoyl-CoA reductase, mitochondrial MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGK VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRD PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIG KQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQP GPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFD GGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
Number of residues
335
分子量
36067.4
Theoretical pI
9.84
GO Classification
Functions
2,4-dienoyl-CoA reductase (NADPH) activity/NADPH binding/oxidoreductase activity, acting on NAD(P)H
Processes
cellular lipid metabolic process/fatty acid beta-oxidation/protein homotetramerization/small molecule metabolic process
Components
cytoplasm/extracellular exosome/mitochondrial matrix/mitochondrion/nucleoplasm/nucleus
General Function
Oxidoreductase activity, acting on nad(p)h
Specific Function
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion
Gene sequence
>lcl|BSEQ0019378|2,4-dienoyl-CoA reductase, mitochondrial (DECR1) ATGAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCT CCTCGGAGGTTTTTCAGTTATGGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAA TCTAAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAA GTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCC AGCCTAGGTGCTCAGTGCGTGATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCA GAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGAT CCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATATT GTGATAAACAATGCAGCAGGGAATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCT TGGAAAACCATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTAGAAATTGGA AAACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCTTTCTATTACTACTATCTATGCT GAGACTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATG AGCAAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCA GGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAA GAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTT GCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGAC GGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAG CAGTGGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAA
Chromosome Location
8
Locus
8q21.3
External Identifiers
Resource Link
UniProtKB ID Q16698
UniProtKB Entry Name DECR_HUMAN
GenBank Gene ID L26050
GenAtlas ID DECR1
HGNC ID HGNC:2753
一般References
  1. Koivuranta KT, Hakkola EH, Hiltunen JK: Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase. Biochem J. 1994 Dec 15;304 ( Pt 3):787-92. [Article]
  2. Helander HM, Koivuranta KT, Horelli-Kuitunen N, Palvimo JJ, Palotie A, Hiltunen JK: Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR). Genomics. 1997 Nov 15;46(1):112-9. [Article]
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB03461 Nicotinamide adenine dinucleotide phosphate experimental unknown Details
DB08605 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL experimental unknown Details