2,4-dienoyl-CoA reductase, mitochondrial
Details
- Name
- 2,4-dienoyl-CoA reductase, mitochondrial
- Synonyms
-
- 1.3.1.34
- 2,4-dienoyl-CoA reductase [NADPH]
- 4-enoyl-CoA reductase [NADPH]
- DECR
- SDR18C1
- Short chain dehydrogenase/reductase family 18C member 1
- Gene Name
- DECR1
- Organism
- Humans
- Amino acid sequence
-
>lcl|BSEQ0006088|2,4-dienoyl-CoA reductase, mitochondrial MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGK VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRD PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIG KQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQP GPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFD GGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
- Number of residues
- 335
- 分子量
- 36067.4
- Theoretical pI
- 9.84
- GO Classification
-
Functions2,4-dienoyl-CoA reductase (NADPH) activity/NADPH binding/oxidoreductase activity, acting on NAD(P)HProcessescellular lipid metabolic process/fatty acid beta-oxidation/protein homotetramerization/small molecule metabolic processComponentscytoplasm/extracellular exosome/mitochondrial matrix/mitochondrion/nucleoplasm/nucleus
- General Function
- Oxidoreductase activity, acting on nad(p)h
- Specific Function
- Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
- Pfam Domain Function
-
- adh_short (PF00106)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
-
>lcl|BSEQ0019378|2,4-dienoyl-CoA reductase, mitochondrial (DECR1) ATGAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCT CCTCGGAGGTTTTTCAGTTATGGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAA TCTAAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAA GTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCC AGCCTAGGTGCTCAGTGCGTGATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCA GAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGAT CCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATATT GTGATAAACAATGCAGCAGGGAATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCT TGGAAAACCATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTAGAAATTGGA AAACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCTTTCTATTACTACTATCTATGCT GAGACTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATG AGCAAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCA GGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAA GAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTT GCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGAC GGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAG CAGTGGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAA
- Chromosome Location
- 8
- Locus
- 8q21.3
- External Identifiers
-
Resource Link UniProtKB ID Q16698 UniProtKB Entry Name DECR_HUMAN GenBank Gene ID L26050 GenAtlas ID DECR1 HGNC ID HGNC:2753 - 一般References
-
- Koivuranta KT, Hakkola EH, Hiltunen JK: Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase. Biochem J. 1994 Dec 15;304 ( Pt 3):787-92. [Article]
- Helander HM, Koivuranta KT, Horelli-Kuitunen N, Palvimo JJ, Palotie A, Hiltunen JK: Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR). Genomics. 1997 Nov 15;46(1):112-9. [Article]
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