Prostaglandin F synthase

Details

Name
Prostaglandin F synthase
Synonyms
  • 1.1.1.188
  • Prostaglandin F2-alpha synthase
Gene Name
Not Available
Organism
Trypanosoma brucei brucei
Amino acid sequence
> lcl|BSEQ0012186|Prostaglandin F synthase MALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGR AIASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWPGKDKFIDT WKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVNQIELHPLLNQKALCEYCKSK NIAVTAWSPLGQGHLVEDARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKEN GNIFDFELTAEDIQVIDGMNAGHRYGPDPEVFMNDF
Number of residues
276
分子量
30992.385
Theoretical pI
6.79
GO Classification
Functions
nucleotide binding/prostaglandin D2 11-ketoreductase activity/prostaglandin-F synthase activity
Processes
prostaglandin biosynthetic process
Components
cytoplasm
General Function
Prostaglandin-f synthase activity
Specific Function
Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
> lcl|BSEQ0006091|831 bp ATGGCTCTCACTCAATCCCTAAAACTCTCGAATGGAGTGATGATGCCAGTTCTTGGTTTC GGTATGTGGAAGTTACAGGATGGCAATGAAGCCGAGACGGCGACGATGTGGGCCATAAAA AGCGGCTATCGTCACATCGATACTGCAGCCATCTATAAAAATGAAGAAAGCGCTGGCAGA GCCATTGCCTCATGTGGTGTACCGCGGGAAGAGCTATTCGTCACGACGAAGCTTTGGAAC TCCGACCAGGGATATGAGAGCACGCTGAGCGCATTTGAGAAGAGCATTAAGAAGCTCGGC CTGGAATATGTTGACCTATACCTCATCCACTGGCCGGGGAAGGACAAGTTTATCGACACA TGGAAGGCGTTTGAGAAACTGTACGCCGATAAGAAGGTGCGCGCCATTGGCGTTTCCAAC TTTCACGAGCACCACATCGAGGAACTGCTAAAGCACTGTAAGGTTGCACCGATGGTTAAC CAGATCGAGCTCCATCCGCTGCTCAATCAGAAGGCACTCTGCGAGTACTGCAAGTCGAAG AACATCGCCGTCACTGCCTGGTCGCCGCTTGGTCAAGGACATCTCGTCGAAGACGCCCGT CTGAAAGCTATCGGAGGAAAGTATGGTAAGACAGCTGCGCAGGTGATGCTCCGCTGGGAA ATACAAGCAGGGGTCATCACGATTCCCAAATCGGGCAACGAGGCCCGCATCAAGGAAAAT GGCAATATATTTGACTTCGAACTAACTGCGGAGGACATTCAAGTCATCGATGGTATGAAT GCCGGCCACCGCTACGGCCCCGATCCGGAGGTCTTCATGAACGACTTTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
Resource Link
UniProtKB ID Q9GV41
UniProtKB Entry Name PGFS_TRYBB
GenBank Gene ID AB034727
General References
  1. Kubata BK, Duszenko M, Kabututu Z, Rawer M, Szallies A, Fujimori K, Inui T, Nozaki T, Yamashita K, Horii T, Urade Y, Hayaishi O: Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. J Exp Med. 2000 Nov 6;192(9):1327-38. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB03461 Nicotinamide adenine dinucleotide phosphate experimental unknown Details
DB04272 Citric acid approved, nutraceutical, vet_approved unknown Details